Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Magnetic fluid for biological medicine and its preparing method

A biomedicine and magnetic fluid technology, applied in the fields of nanotechnology and biomedicine, can solve the problems of large particle size of magnetic starch composite particles, limited application, wide particle size distribution, etc., achieve good biocompatibility, reduce production costs, Simple and easy preparation method

Inactive Publication Date: 2006-08-23
EAST CHINA NORMAL UNIVERSITY
View PDF0 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large particle size and wide particle size distribution of magnetic starch composite particles, its application in the field of biomedicine is limited, especially in the application of magnetically targeted drug technology.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Separately prepare Fe with twice distilled water 3+ and Fe 2+ mixed aqueous solution and NaOH solution. Fe in the mixed aqueous solution of iron salt 3+ The ion concentration is 0.8mol / L, Fe 2+ The concentration is 0.4mol / L. Add 6 g of soluble starch by weight into 50 g of twice-distilled water, and heat to 80° C. to dissolve it. Get the mixed aqueous solution 24mL of iron salt and add in the starch solution, under N 2 Under protection, stir evenly. Add 1 mol / L NaOH solution dropwise to the mixed solution at 80°C until the pH of the mixed solution is 10-11, so that the hydrolysis tends to be complete. Stirring was continued at 80° C. for 2 h to obtain a black magnetic suspension. After adjusting the pH value of the suspension to neutrality with dilute hydrochloric acid, centrifuge at 1500r / min for 15min to remove the sediment in the suspension, and then dialyze through double distilled water for 2 to 3 days to remove unreacted starch and other non-reacted starche...

Embodiment 2

[0030] Separately prepare Fe with twice distilled water 3+ and Fe 2+ mixed aqueous solution and ammonia solution. Fe in the mixed aqueous solution of iron salt 3+ The ion concentration is 0.2mol / L, Fe 2+ The concentration is 0.1mol / L. Add 2g of soluble starch into 40g of double distilled water, and heat to 60°C to dissolve it. Get the mixed aqueous solution 24mL of iron salt and add in the starch solution, under N 2Under protection, stir to mix well. Add 1 mol / L ammonia solution dropwise to the mixed solution at 60°C until the pH of the mixed solution is 10-11, so that the hydrolysis tends to be complete. Stirring was continued at 60° C. for 2 h to obtain a black magnetic suspension. Use dilute hydrochloric acid to adjust the pH value of the suspension to neutral, centrifuge at 1500r / min for 15 minutes to remove the sediment in the suspension, and then dialyze through double distilled water for 2 to 3 days to remove unreacted starch and other non-magnetic components . ...

Embodiment 3

[0032] Separately prepare Fe with twice distilled water 3+ and Fe 2+ mixed aqueous solution and ammonia solution. Fe in the mixed aqueous solution of iron salt 3+ The ion concentration is 0.4mol / L, Fe 2+ The concentration is 0.2mol / L. Add 4g of soluble starch into 50g of twice distilled water, and heat to 70°C to dissolve it. Get the mixed aqueous solution 24mL of iron salt and add in the starch solution, under N 2 Under protection, stir to mix well. Add 1 mol / L ammonia solution dropwise to the mixed solution at 70°C until the pH of the mixed solution is 10-11, so that the hydrolysis tends to be complete. Stirring was continued at 70° C. for 2 h to obtain a black magnetic suspension. After adjusting the pH value of the suspension to neutral with dilute hydrochloric acid, centrifuge at 1500r / min for 15min to remove the sediment in the suspension, and then dialyze through double distilled water for 2-3 days to remove unreacted starch and other non-magnetic components . ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

Present invention relates to magnetic fluids for biologic medicine. It contain water, magnetic nano granule and hydrophilicity organic high polymer substance, wherein hydrophilicity organic high polymer substance covered on magnetic nano granulometric surface, hydrophilicity organic high polymer magnetic nano granule homodisperse in water phase, magnetic nano granule being magnetic inorganic nano granule, hydrophilicity organic high polymer substance being water-solubility whose coating layer surface having functional group hydroxy-OH or aldehyde group-CHO, magnetic inorganic nano granule being particle diameter of 5-20 nm of Fe<3>0<4>, the particle diameter of magnetic inorganic nano granule compound granule covered with water-solubility starch bring less than 50nm.Said magnetic fluids has good biologic consistency, biodegradability, suspension stability and magnetic responsibility, can be used in cell separation, tumour heat treatment, nuclear magnetic resonance radiography imaging and target drug delivery etc biomedical field. Said invention provides two magnetic fluids preparation methods.

Description

technical field [0001] The invention relates to a magnetic fluid for biomedicine and a preparation method thereof, belonging to the fields of nanometer science and technology and biomedicine. Background technique [0002] Magnetic fluid, also known as magnetic liquid, is one of the important application fields of nanomaterials. It has both the magnetism of solid materials and the fluidity of liquid materials, and is a new type of liquid functional material. Early ferrofluids were mainly used in sealing, lubrication, damping, grinding, separation, printing and printing, and environmental protection, etc., and achieved great success. In recent years, with the development of nanoscience and technology, magnetic nanoparticles have broad application prospects in the field of biomedicine due to their biocompatibility and special magnetic properties, such as immobilized enzymes, targeted drugs, controlled release, nuclear magnetic Resonance contrast imaging, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): H01F1/44H01F41/00
Inventor 姜继森甘志峰杨勇
Owner EAST CHINA NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com