Preparation method of hepatitis vaccine and its use

A hepatitis B vaccine and a new type of technology, applied in the field of human hepatitis B vaccine and its preparation, can solve the problems of granulomatous inflammation, contact allergic reaction, local reaction, etc., achieve reduction of inflammatory nodules, reduction of inflammatory response, The effect of reducing side effects
CN1824304AInactive Publication Date: 2006-08-30THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
Publication Date
2006-08-30
Estimated Expiration
Not applicable · inactive patent
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Abstract

A human rabies vaccine is prepared from the existing hepatitis B vaccine without adjuvant through adsorbing it by the aluminum hydroxide nanoparticles. Its adsorbed capacity is increased by 10-20 time. It can be used for emergency inoculation for preventing hepatitis B as it has the fast release effect.
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Description

Technical field

[0001] The invention relates to a hepatitis B vaccine for human use and a preparation method thereof, in particular to a hepatitis B vaccine containing a nano aluminum adjuvant and a preparation method thereof. technical background

[0002] The main component of hepatitis B vaccine is HBsAg with an isoelectric point of 4.5. HBsAg contains a large number of phosphate groups. Because the isoelectric points (iep) of HBsAg and aluminum hydroxide adjuvant are 4.5 and 11.4, respectively. Therefore, in the neutral environment of the body with pH=7.4, the former shows a negative charge and the latter shows a positive charge. The two can have a good adsorption effect due to electrostatic force.

[0003] The main mechanisms of aluminum adjuvant adsorption of antigens include electrostatic force, hydrophobic interaction and group exchange [Vogel FR, Hem SL. In: Plotkin SA, Orenstein MD, editors. Vaccines. 4th ed. New York: Sanders]. The adsorption caused by hydrophobic inter...

Claims

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