Method for preparing medical filler with non-crystal oxide ion-slow-release surface

A technology of amorphous oxides and implant materials, which is applied in the field of preparation of medical biomaterials, can solve the problems of high solubility, insufficient interaction ability, and insufficient activity, and achieves simple process, promotion of adsorption, and promotion of mineralization. Effect

Inactive Publication Date: 2006-10-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the hydroxyapatite coating has obvious disadvantages: First, its solubility is relatively large, which will cause the long-term durability of the coating to decrease
Secondly, its activity is still not strong enough to promote the interaction between...

Method used

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Examples

Experimental program
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Effect test

example 1

[0019] Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OEt) 3-X The phosphoric acid with a concentration of 1 mol / L was mixed with the phosphoric acid hexafluorophosphoric acid in a molar ratio of F:P=0.15:1 in an ice-water bath environment. Calcium nitrate was dissolved in the above mixed solution with a molar ratio of Ca:P=0.8:1, and heated to reflux for 24 hours. The zinc nitrate is dissolved in the refluxed mixed solution according to the proportion of trace elements accounting for 0.01% of the mass of the solute to form a sol. After immersing the Ti6A14V substrate in the sol for 5 hours, slowly pull it out of the liquid surface at a speed of 0.5 cm / min by dipping and pulling method, dry it at 150°C, and heat-treat it at 500°C for 15 minutes to obtain A medical implant material with an ion slow-release surface layer.

example 2

[0021] Dissolve triethyl phosphite in ethanol to form a 2 mol / L solution, and mix this solution with trifluoroacetic acid at a molar ratio F:P=0.15:1 in an ice-water bath environment. Calcium nitrate was dissolved in the above mixed solution with a molar ratio of Ca:P=1:1, and heated to reflux for 24 hours. The zinc nitrate is dissolved in the refluxed mixed solution according to the proportion of trace elements accounting for 0.04% of the mass of the solute to form a sol. After immersing the pure titanium substrate in the miscible glue for 8 hours, slowly pull it out of the liquid surface at a speed of 0.5 cm / min by dipping and pulling method, after drying at 180°C, heat treatment at 400°C for 4 hours, A medical implant material with zinc ion sustained release surface layer is obtained.

example 3

[0023] Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OEt) 3-X Phosphoric acid with a concentration of 1 mol / L, the solution was mixed with ammonium hexafluorophosphate in a molar ratio of F:P=0.12:1 in an ice-water bath environment. Calcium nitrate was dissolved in the above mixed solution with a molar ratio of Ca:P=0.9:1, and heated to reflux for 24 hours. The zinc nitrate is dissolved in the refluxed mixed solution to form a sol according to the proportion that the trace element is 0.03% of the mass of the solute. After immersing the Ti6Al4V substrate in the mixed solution for 10 hours, slowly pull it out of the liquid surface at a speed of 0.4 cm / min by dipping and pulling method, preheat at 200°C for 20 minutes, and heat treat at 450°C for 2 hours to obtain The amorphous oxide surface layer with zinc slow release function.

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Abstract

The present invention discloses a method for preparing medical implantation material with amorphous oxide ion delayed-release surface layer. Said method includes the following steps: (1), under the ice water bath environment mixing phosphate or partially-esterified phosphoric mixture with fluorinated compound, then adding calcium salt which can be dissolved in liquid alcohol, heating and refluxing said mixed solution, adding salt containing trace element to form sol; and (2), soaking metal base body in said sol, then adopting impregnation pulling process or rotary coating process to coat the surface of said metal base body, drying and making heat-treatment at 500-750 deg.C.

Description

technical field [0001] The invention relates to a method for preparing medical biomaterials, in particular to a method for preparing medical implant materials with an amorphous oxide ion slow-release surface layer. Background technique [0002] Medical metal implants are widely used in teeth, bones, joints and other parts for the repair of diseased or defective tissues. Since these hard tissues are load-bearing parts, the purpose of using metal matrix is ​​to take advantage of its good mechanical properties. However, as a biological material, it must have good compatibility and good combination with biological tissues to ensure successful implantation. Usually pure metal materials are difficult to meet the requirements of biological activity performance. At present, the method of coating a layer of active coating capable of depositing osteoid apatite on the surface of medical metal substrate or forming a metal oxide coating on its surface is often used to enhance its biolo...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/50
Inventor 程逵翁文剑宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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