Lmiquimod cream and preparation method thereof

Abstract

The present invention relates to imiquimod cream containing imiquimod of grain size not greater than 100 micron in 1.0-10.0 wt%, oil phase, water and emulsifier. The preparation process of imiquimod cream includes the following steps: heating at 75-85 deg.c to smelt oil phase with added thickener and anodyne; mixing humectant and water to obtain water phase and heating to 75-85 deg.c; mixing imiquimod, emulsifier, preservative, oil phase and water phase via maintaining the temperature and stirring for 15-20 min; and regulating pH value to 4.0-7.0 to obtain the imiquimod cream. The medicine of the present invention has raised permeating absorption and raised curative effect, and is used in treating condyloma acuminatum around male's and female's external genitalia and anus.

Description

technical field

[0001] The invention belongs to a medicine of an immune response regulator, and in particular relates to an imiquimod cream preparation and a preparation method. Background technique

[0002] Warts are one of the diseases caused by human papillomavirus (HPV) infection of the skin and mucous membranes. Among them, genital warts are the most common sexually transmitted diseases worldwide. According to the report of the Centers for Disease Control and Prevention (CDC), 5-20% of people aged 15-49 are infected with this disease, and there are 750,000 new patients every year. Once suffering from this disease, patients not only suffer physically, but also often have a sense of shame and guilt mentally.

[0003] Current treatments for external genital and perianal warts include chemotherapy and physical excision. Podophyllotoxin and interferon are drugs that have been approved to treat genital warts so far. Podophyllotoxin is the only drug that uses self-treatment....