Preparation method of hyperin and hypericin of Hypericum perforatum

A technology of hypericin and hypericin is applied in chemical instruments and methods, preparation of sugar derivatives, medical preparations containing active ingredients, etc. issues such as

Inactive Publication Date: 2006-12-20
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing method of preparing hypericin by using the plant Hypericum perforatum only prepares a single hypericin, does not prepare hypericin at the same time, fails to make full use of the rich resources of Hypericum perforatum in my country, and there are still a large amount of hypericin in the production process. Waste liquid discharge, pollute the environment

Method used

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  • Preparation method of hyperin and hypericin of Hypericum perforatum
  • Preparation method of hyperin and hypericin of Hypericum perforatum

Examples

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Embodiment 1

[0055] A preparation method of hypericin and hypericin in Hypericum perforatum, the concrete method steps are as follows:

[0056] (1) Preparation of Forsythia extract

[0057] After the fruit of Hypericum perforatum is crushed into forsythia powder, the ratio of the weight of the forsythia powder to the volume of 85% ethanol is 1:10, adding 85% ethanol to the forsythia powder, and refluxing extraction at a temperature of 70 ° C. After 4 hours, it was filtered again and the filtrate was collected. For the filter residue, the ratio of the weight of the filter residue to the volume of 70% ethanol is 1:5, and then reflux extraction with 70% ethanol for 2 hours, then filter and collect the filtrate, discard the filter residue, and then use 70% ethanol. The filtrate was placed in an evaporator, and concentrated under -0.08MPa vacuum to form Hypericum perforatum extract and recovered ethanol. The ethanol concentration in the recovered and distilled ethanol is measured with an alco...

Embodiment 2

[0091] A preparation method of hyperin and hypericin in Hypericum perforatum, the specific method steps are as follows:

[0092] (1) Preparation of forsythia extract

[0093] After the Hypericum perforatum fruit is crushed into Forsythia powder, add 95% ethanol to the Forsythia powder at a ratio of 1:20 by the weight of the Forsythia powder and the volume of 95% ethanol, and extract under reflux at a temperature of 85°C After 6 hours, filter again and collect the filtrate. For the filter residue, the ratio of the weight of the filter residue to the volume of 80% ethanol is 1:10, and then reflux extraction with 80% ethanol for 3 hours, then filter and collect the filtrate, and discard the filter residue. Then, the filtrate collected twice was placed in an evaporator, concentrated into Hypericum perforatum extract and recovered ethanol under a vacuum of -0.05MPa. Measure the concentration of ethanol in the recovered and distilled ethanol with an alcohol meter, then adjust it t...

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Abstract

This invention relates to a method for producing Hypericum perforatum hyperoside and hypericin. This invention comprehensively utilizes Hypericum perforatum fruits which are rich in our country to produce both hyperoside and hypericin pharmaceutical active components with high recovery rate, high product purity, and low cost. During the producing process, it achieves the recovery and cycling use of many solvents like ethanol and ethyl ether, and also achieves the regeneration and cycling use of micelle reextracting agent and absorption resin. The plant biological active compounds produced by this invention can be broadly used in heat-clearing and detoxifying, astringing to arrest bleeding and promote diuresis, and antidepressant drug.

Description

1. Technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical active ingredients, in particular to a preparation method of hyperin and hypericin medicinal active ingredients. 2. Background technology [0002] Studies have shown that hypericin and hyperoside are the main active ingredients used in medicines for clearing heat and detoxifying, astringent and hemostasis, diuresis and depression treatment. Practice has proved that hyperoside has anti-allergic, anti-inflammatory, antispasmodic, diuretic, significant cough, lowering blood pressure, cholesterol and tumor effects, especially has the function of analgesia and heart protection, and can promote the prevention of diabetic cataracts, etc. ;Hypericin has the functions of regulating the human body's circadian rhythm, improving sleep, and relaxing the central nervous system. It has inhibitory effects on AIDS, herpes simplex virus, parainfluenza virus, and vaccinia virus. Hepatitis C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07C50/36C07H1/08C07C46/10A61K31/7048A61K31/122A61P29/00A61P9/12A61P25/24A61P27/12A61P35/00A61P11/14A61P13/02
Inventor 周小华李端华高晶
Owner CHONGQING UNIV
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