Probiotic double layer embed microcapsule process

A double-layer embedding and probiotic technology, which is applied in the direction of fixing on/in the organic carrier, can solve the problems of poor thermal stability, large influence of water activity, and non-durable storage.

Active Publication Date: 2006-12-27
湖南科尔生物技术有限公司
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AI Technical Summary

Problems solved by technology

[0002] At present, there are endless probiotic products on the market, but most probiotic products are probiotic products without embedding treatment, such as yogurt, probiotic oral liquid or nutrient solution, freeze-dried bacteria powder, etc., due to gastric acid, bile, etc. Acid has a bactericidal effect, and these probiotics will be inactivated after entering the human body, and cannot exert their ideal curative effect, and are not durable
There are several embedding technologies for probiotic products in the prior art, one of which is giant-encapsulated probiotics, which is wrapped in hard capsules, which can protect lactic acid bacteria from passing through the stomach, but hard capsules are not easy to dissolve and not Long-term storage; there is also a microcapsule-embedded probiotic product, this microcapsule-embedded type is durable and resistant to gastric acid, but its ther

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of bifidobacterium microcapsule:

[0013] 1. Carry out mixed fermentation culture bifidobacterium according to existing technology, microfiltration centrifugation collects bacteria;

[0014] 2. Preparation of bacterial milk protein embedding solution: 75 grams of bifidobacterium concentrate, 15 grams of milk protein, 10 grams of capsule core accessories (polyvinylpyrrolidone PVP K30, cellooligosaccharide) at a temperature below 30°C and a humidity of 55%. Stir and mix for 30 minutes and homogenize for 20 minutes in an environment with a cleanliness level of 100,000 or less;

[0015] 3. Preparation of enteric gel coating solution: 16 grams of modified starch, 6 grams of gum arabic, 8 grams of polyethylene glycol, 6 grams of sodium alginate, 4 grams of chitosan, added to 60 ml of 0.9% sodium chloride solution Mixing, high-speed shear emulsification and dispersion, passing through a 100-mesh sieve, and ultrasonication for 15 minutes to prepar...

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PUM

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Abstract

The invention discloses a probiotics double-embedded microcapsule technology. The acid-proof double-embedded enteric-coated microcapsule is prepared with 75 % probiotics enriched solution, 15 % milk protein, 10 % capsule-core findings and enteric solubility colloid comprising 12-20 % converted starch, 4-8 % acacia gum, 6-10 % carbowax, 4-8 % sodium alginate, 3-5 % chitose and 60 % common salt with concentration of 0.9 % by fluidized spray-on process. The products by this double-embedded microcapsule technology can resist acid stomach and bile acid and is shelf stable, and can immediately dissolve and release after reaching small intestine and can colonize on adsorption intestinal canal mucous membrane, and the process is much easier and the cost is much lower.

Description

technical field [0001] The invention relates to a probiotic double-layer embedding microcapsule process. Background technique [0002] At present, there are endless probiotic products on the market, but most probiotic products are probiotic products without embedding treatment, such as yogurt, probiotic oral liquid or nutrient solution, freeze-dried bacteria powder, etc., due to gastric acid, bile, etc. Acid has a bactericidal effect, and these probiotics will be inactivated after entering the human body, and cannot exert their ideal curative effect, and they are not durable. There are several embedding technologies for probiotic products in the prior art, one of which is giant-encapsulated probiotics, which is wrapped in hard capsules, which can protect lactic acid bacteria from passing through the stomach, but hard capsules are not easy to dissolve and not Long-term storage; there is also a microcapsule-embedded probiotic product, this microcap...

Claims

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Application Information

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IPC IPC(8): C12N11/04
Inventor 肖宏苏小平李敏艳
Owner 湖南科尔生物技术有限公司
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