Process for preparing biologically degradable SiO2/poly lactic acid nano composite material

A nanocomposite material, silicon dioxide technology, applied in the field of preparation of silicon dioxide/polylactic acid nanocomposite materials, can solve problems affecting the application of terminal materials, achieve high use value, improve tensile strength and elongation at break , Improve the effect of thermal stability

Inactive Publication Date: 2007-04-11
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, coupling agents and coating agents are usually harmful substances, which affect the application of terminal materials in the medical field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Disperse 30 grams of silica nanoparticles (particle size 20-50nm) in 200ml of toluene solvent, slowly add 45ml of lactic acid dropwise under stirring, after the dropwise addition, dehydration and polycondensation reaction at 160°C for 20 hours, and then The product was repeatedly washed with tetrahydrofuran and dichloromethane 5 times to remove unsupported lactic acid oligomers; then dried in vacuum at 40° C. for 48 hours to obtain surface-grafted modified silica nanoparticles.

[0018] Get 3 grams of modified silicon dioxide nanoparticles and disperse them in 18 grams of chloroform solvent, add respectively containing 97g, 57g, 27g, 12g, 7g of molecular weight and be 200,000 polylactic acid chloroform solution (polylactic acid concentration is 0.5g / ml); then fully stirred for 5 hours, and ultrasonically dispersed for 1 hour; pour the solution into a mold, wait for the solvent to volatilize, obtain a composite material film after 7 days, and vacuum dry it at 40°C for 48...

Embodiment 2

[0022] The process and steps of this embodiment are exactly the same as those of the above-mentioned embodiment 1, except that 60 ml of lactic acid is added when the surface of the silica nanoparticles is modified.

[0023] The mechanical property test result of the polylactic acid composite material that makes is shown in the following table 2: (in order to facilitate comparison, also did not add SiO 2 test)

[0024]

Embodiment 3

[0026] Disperse 60 grams of silica nanoparticles (particle size 20-50nm) in 400ml of toluene solution, add 120ml of lactic acid dropwise under stirring, after the dropwise addition, dehydration and polycondensation reaction at 150°C for 36 hours, and then use the product Tetrahydrofuran and dichloromethane were repeatedly washed 5 times to remove unloaded lactic acid oligomers; then vacuum-dried at 40° C. for 48 hours to obtain surface-modified silica nanoparticles.

[0027] Put 1.5g, 2.5g, 4.5g, 6g, 7.5g, 10g of modified silica nanoparticles (the loading of lactic acid oligomers is 12.5wt%) and 50g of polylactic acid with a molecular weight of 180,000 in an internal mixer Medium melt blending, the speed of the internal mixer is 36rpm, the mixing time is 10 minutes, the mixture is transferred to a hot press and pressed at 180°C and 15MPa for 5 minutes to obtain a silica / polylactic acid nanocomposite film .

[0028] Different SiO will be prepared 2 content of the polylactic a...

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Abstract

The present invention relates to preparation process of biodegradable nanometer silica / polylactic acid composite material, and belongs to the field of nanometer composite material preparing technology. The preparation process includes the following steps: 1. dispersing nanometer silica particle in solvent, and adding lactic acid to produce dehydrating polycondensation and obtain polylactic acid with nanometer silica particle grafted to the surface; and 2. dispersing modified nanometer silica particle in solvent, adding the high molecular weight polylactic acid in the weight ratio between nanometer silica and polylactic acid being 3-30 %; stirring, ultrasonically dispersing, molding and volatilizing solvent to obtain nanometer composite material film; and drying at 40deg.c for 48 hr to obtain final product.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable silicon dioxide / polylactic acid nanocomposite material, which belongs to the technical field of nanoparticle / polymer composite material preparation technology. Background technique [0002] Polylactic acid is a kind of fully biodegradable material widely used at present. It has low immunity, good biodegradability, biocompatibility and excellent mechanical properties, so it is widely used in the fields of biomedicine and medicine. Such as fracture fixation materials, surgical sutures, tissue engineering scaffold materials, drug sustained release carrier materials, etc. However, there are still some disadvantages when polylactic acid is used as a biomedical material, such as: (1) insufficient hydrophilicity and weak cell adhesion; (2) easy to cause aseptic inflammation, which was found during the clinical application of polylactic acid Patients have a high rate of non-specific aseptic inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08K9/00C08J5/18C08K3/36
Inventor 颜世峰尹静波杨艳陈学思
Owner SHANGHAI UNIV
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