Curcuma zedoary oil fat injection and preparation process
A technology of injection and zedoary oil, which is applied in the direction of emulsion delivery, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of vein irritation, high incidence of phlebitis, pain, etc., to reduce irritation, Protect active ingredients and reduce toxic and side effects
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Embodiment 1
[0030] Weigh 10g of refined curcuma oil, dissolve it in 90ml of soybean oil, and mix it evenly to obtain the oil phase; take 15g of glycerin for injection and dissolve it in 700ml of water for injection, and mix it evenly to obtain the water phase; another 12g of soybean lecithin is added to the water phase Put it in a tissue masher, stir it at a high speed under the protection of nitrogen to a homogeneous liquid, then add the oil phase, stir it at a high speed to obtain colostrum, and adjust the pH value to 3.5-5.5.
[0031] Emulsion the colostrum twice under the pressure of 11000psi through a high-pressure homogenizer, add water for injection to 1000ml, and homogenize once at a pressure of 9000psi to obtain an emulsion, filter through a 0.45μm microporous membrane, and seal the 10ml ampoule with nitrogen gas In the process, steam sterilization at 100°C for 30 minutes, and after passing the inspection, the zedoary oil fat emulsion injection was obtained.
Embodiment 2
[0033] Weigh 10g of refined curcuma oil, dissolve it in 190ml of soybean oil, and mix it evenly to obtain the oil phase; take 20g of glycerin for injection and dissolve it in 600ml of water for injection, and mix it evenly to obtain the water phase; another 15g of soybean lecithin is added to the water phase Put it in a tissue masher, stir it at a high speed under the protection of nitrogen to a homogeneous liquid, then add the oil phase, stir it at a high speed to obtain colostrum, and adjust the pH value to 3.5-5.5.
[0034] Emulsion the colostrum twice under the pressure of 11000psi through a high-pressure homogenizer, add water for injection to 1000ml, and homogenize once at a pressure of 9000psi to obtain an emulsion, filter through a 0.45μm microporous membrane, and seal the 10ml ampoule with nitrogen gas In the process, steam sterilization at 100°C for 30 minutes, and after passing the inspection, the zedoary oil fat emulsion injection was obtained.
Embodiment 3
[0036] Weigh 10g of refined curcuma oil, dissolve it in 90ml of cottonseed oil for injection, and mix evenly to obtain an oil phase, take 15g of propylene glycol for injection and dissolve it in 700ml of water for injection, and mix evenly to obtain an aqueous phase; another 12g of lecithin is added to In the water phase, put it in a tissue masher, stir at a high speed under the protection of nitrogen until it becomes a homogeneous liquid, then add the oil phase, stir at a high speed to obtain colostrum, and adjust the pH value to 3.5-5.5.
[0037] Emulsion the colostrum twice under the pressure of 11000psi through a high-pressure homogenizer, add water for injection to 1000ml, and homogenize once at a pressure of 9000psi to obtain an emulsion, filter through a 0.80μm microporous membrane, and seal the 20ml ampoule with nitrogen gas In the process, steam sterilization at 100°C for 30 minutes, and after passing the inspection, the zedoary oil fat emulsion injection was obtained....
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