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Peroxisome proliferator-activated receptor (PPAR) activator and drugs, supplements, functional foods and food additives using the same

A technology of peroxisomes and proliferators, which can be used in food preparation, active ingredients of hydroxyl compounds, and medical preparations containing active ingredients, etc., and can solve the problem of high oil and calories

Active Publication Date: 2007-05-02
ARKRAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even substances derived from natural ingredients are high in calories such as fats and oils, so there is a problem with continuous intake
In addition, for daily intake, it is ideal to add to food, etc., but many substances derived from natural ingredients have a special taste, and such substances are not suitable for adding to food, etc.

Method used

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  • Peroxisome proliferator-activated receptor (PPAR) activator and drugs, supplements, functional foods and food additives using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This example is an example of confirming the activation of PPARγ by β-cryptoxanthin.

[0043] First, CV-1 cells (cultured cells from the kidney of male African green monkeys) were seeded in 24-well culture plates at 0.2 μg / well, and incubated at 37°C, 5% CO 2 Conditioned for 24 hours. As a medium, DMEM (Dulbecco's Modified Eagle Medium, GIBCO) containing 10% FBS (fetal bovine serum) and 10 mg / mL penicillin-streptomycin solution was used. Next, pM-hPPARγ and p4×UASg-tk-luc were transfected into cultured CV-1 cells using the Lipofectamine system (Invitrogen). In addition, the aforementioned pM-hPPARγ is a vector for expressing a fusion protein comprising 1 to 147 residues as the GAL4-binding domain and 204 to 505 residues as the human PPARγ ligand-binding domain. The above p4×UASg-tk-luc is a reporter plasmid containing 4 copies of an upstream activating sequence (UAS) for the GAL4-binding domain and a thymidine kinase gene promoter upstream of the luciferase gene. The...

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Abstract

The present invention provides a peroxisome proliferator-activated receptor (PPAR) activator that has no problem of side effects, can be ingested for a long period of time, and has no special taste, using β-cryptoxanthin as the PPAR activator. β-Cryptoxanthin is contained in a large amount in the pulp of citrus (especially tangerine citrus) such as Wenzhou citrus. Since it has been eaten for many years, there is no problem in safety and low in calories, so it can be taken for a long time. In addition, since β-cryptoxanthin is tasteless and odorless, even if it is added to food, it will not impair the unique flavor of the food, so it can be added to food and ingested.

Description

technical field [0001] The present invention relates to a peroxisome proliferator-activated receptor (PPAR) activator and medicines, supplements, functional foods and food additives using the activator. Background technique [0002] The onset of diabetes is said to be related to both decreased insulin secretion and insulin resistance. Recently, among the Japanese, the number of diabetic patients has increased, and since the decrease in insulin secretion is largely due to genetics, it is considered that the main cause of the increase in diabetic patients is insulin resistance. This is due to the Westernization of the Japanese diet, increased fat intake, lack of exercise, obesity, and stress. In recent studies, it has been found that the mechanism of insulin resistance is caused by the hypertrophy of fat cells. That is, when adipocytes become hypertrophic, they secrete TNF-α and free fatty acids (FFA), which inhibit the uptake of sugar in muscle cells and liver cells, and al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A23L1/30A61K36/752A61P3/04A61P3/06A61P3/10A61P9/10A61P9/12A61P43/00A23L29/00
CPCA61K36/752A23L1/3002A61K31/045A23L33/105A61P3/10A61P3/04A61P3/06A61P43/00A61P9/10A61P9/12
Inventor 佐佐木贵生
Owner ARKRAY INC