Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis

a technology of angiogenesis and compositions, applied in the direction of angiogenin, drug compositions, peptides, etc., can solve the problems of reduced exercise tolerance, impaired quality of life, and left ventricular dysfunction
US20030100497A1Inactive Publication Date: 2003-05-29GENENTECH INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
GENENTECH INC
Publication Date
2003-05-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and / or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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Description

1. FIELD OF THE INVENTION

[0001] The present invention relates to compositions and methods useful for the modulation (e.g., promotion or inhibition) of angiogenesis and / or cardiovascularization in mammals in need of such biological effect. The present invention further relates to the diagnosis and treatment of disorders involving angiogenesis (e.g., cardiovascular as well as oncological disorders).2. BACKGROUND OF THE INVENTION2.1. Angiogenesis

[0002] Angiogenesis, defined as the growth or sprouting of new blood vessels from existing vessels, is a complex process that primarily occurs during embryonic development. Under normal physiological conditions in adults, angiogenesis takes place only in very restricted situations such as hair growth and wounding healing (Auerbach, W. and Auerbach, R., 1994, Pharmacol Ther 63(3):265-311; Ribatti et al., 1991, Haematologica 76(4):311-20; Risau, 1997, Nature 386(6626):67 1-4). Unregulated angiogenesis has gradually been recognized to be responsib...

Claims

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