Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse
a selective chloride channel and modulator technology, applied in the direction of biocide, drug composition, peptide/protein ingredients, etc., can solve the problems of increasing the compulsion to take more drugs, depressed motivation and mood, and depressed mood, so as to reduce cravings and withdrawal symptoms, and control cravings
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Examples
example 1
Treatment of Patients With Flumazenil in Multiple Dosages at Predetermined Time Periods
1.1 Experimental Protocol
[0252] 64 alcoholics (51 males and 13 females) voluntarily entered a treatment program to discontinue the use of alcohol. The patients were provided the appropriate information and the corresponding informed consent form was obtained from them. The patients were warned not to drink alcohol the morning on which the treatment was to be carried out to enable better evaluation of the withdrawal symptoms. Table 14 summarizes the characteristics of the patients treated associated with alcohol use.
TABLE 14Characteristics of Patients Associated withAlcohol Use (note: 85% consumed alcohol daily and 39.1%consumed benzodiazepines daily).STANDARDMINI-MAXI-CHARACTERISTICSMEANDEVIATIONMUMMUMAGE (YEARS)42.710.22075AGE AT BEGINNING24.610.2671OF DAILY ALCOHOLUSE (YEARS)DAILY UNITS OF24.915.4473ALCOHOL INTAKEGAMMA-GLUTAMYL159.1227.2121.230TRANSPEPTIDASE(GGT)CORPUSCULAR97.86.472111VOLUM...
example 2
Improved Methodology for the Administration of Flumazenil to Treat Alcohol Dependency
[0276] Before starting the protocol, the patients underwent a complete medical and psychological examination. The monitoring of the patients included a complete blood count, a biochemical profile [creatinine, glucose, blood urea nitrogen (BUN), cholesterol (HDL and LDL), triglycerides, alkaline phosphatase, LDH (lactic dehydrogenase) and total proteins], hepatic function tests [GOT, GPT, GGT, bilirubin), electrocardiogram and, if need be, pregnancy test and x-ray examination. The exclusion criteria applied included acute or uncompensated illnesses, as well as the taking of any drug contraindicated with flumazenil. No patient was excluded after the pre-admission interview and the tests performed.
[0277] In addition, patients diagnosed with a psychotic disorder received anti-psychotic medication. Patients diagnosed with arterial hypertension are prescribed the appropriate medication or instructed to ...
example 3
Improved Methodology for the Administration of Flumazenil to Treat Alcohol Dependency
[0281] In accordance with this embodiment of the present invention, as related to such example, a protocol for the treatment of alcohol cravings is described in the table below:
Day 3 -TimeAdmission DayDay 2DischargePre-ProcedureAtaraxAtaraxFortified(AM)(sedative) -(sedative) -Vitamin B50 mg (1-2 hour50 mg (1-2 hourcomplex.pre-procedure).pre-procedure).May repeat withMay repeat withProtein25 mg for25 mg forDrink.anxiety ifanxiety ifneeded.needed.FortifiedFortifiedVitamin BVitamin Bcomplex.complex.Protein Drink.Protein Drink.ProcedureFlumazenil 2 mgFlumazenil 2 mgper dayper dayPost-ProcedureAtarax 50 mg. atAtarax 50 mg. at(PM)bedtime maybedtime mayrepeat with 25 mg.repeat with 25 mg.as neededas neededfor sleep.for sleep.
[0282] At discharge, the following may be administered: disulfiram 250 mg., daily for six months; glutamic acid, 500 mg., once daily for one day, twice daily for one day, then three...
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Abstract
Description
Claims
Application Information
- IPC
- A61K31/195; A61K31/551
- CPC
- A61K31/137; A61K31/195; A61K31/551; A61K31/5517; A61K45/06; A61K2300/00; A61P25/30; A61P25/32
- Inventors
- LEGARDA IBANEZ, JUAN JOSE