Anti-angiogenic compositions and methods of use

a technology of compositions and compositions, applied in the field of compositions and methods for treating cancer and other angiogenicdependent diseases, can solve the problems of radiotherapy and chemotherapy agents being toxic to normal tissues, having life-threatening side effects, and often having extremely high failure/remission rates, and achieve the effect of occludemen
US20050208137A1Inactive Publication Date: 2005-09-22ANGIOTECH PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ANGIOTECH PHARMA INC
Publication Date
2005-09-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal / bronchial obstructions.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of co-pending PCT application CA94 / 00373, filed Jul. 19, 1994. In addition, this application is a continuation-in-part of pending U.S. patent application Ser. No. 08 / 094,536, filed Jul. 19, 1993.TECHNICAL FIELD

[0002] The present invention relates generally to compositions and methods for treating cancer and other angiogenic-dependent diseases, and more specifically, to compositions comprising anti-angiogenic factors and polymeric carriers, stents which have been coated with such compositions, as well as method for utilizing these stents and compositions. BACKGROUND OF THE INVENTION

[0003] Angiogenesis-dependent diseases (i.e., those diseases which require or induce vascular growth) represent a significant portion of all diseases for which medical treatment is sought. For example, cancer is the second leading cause of death in the United States, and accounts for over one-fifth of the total mortality. ...

Claims

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