Agent for protection of tooth surfaces, in conjunction with conventional bleaching methods, by biomimetic deposition of fluorapatite

Abstract

An agent for protection of tooth surfaces, in conjunction with conventional bleaching methods, by biomimetic deposition of fluorapatite, containingA at least one preformulated 50-1000 μm thick gel film A, containingA1 at least one gel former,A2 water or a mixture of water and an organic solvent,A3 phosphate or hydrogen phosphate ions,A4 optionally fluoride,A5 optionally at least one amino acid,A6 optionally one carboxylic acid or a buffer system for a pH value from 4 to 7.B at least one 50 μm to 5 mm thick gel film B, containingB1 at least one gel former,B2 water,B3 calcium ions Ca2+.

Description

[0001]The invention concerns an agent to protect dental surfaces, in conjunction with conventional bleaching methods, by biomimetic deposition of fluorapatite.BACKGROUND[0002]Bleaching systems that act by means of strong oxidizers are mostly used for brightening of teeth. Depending on the form of application, the concentrations lie between 10-35% peroxide. In particular, concentrated hydrogen peroxide solutions or carbamide peroxide are used. The action mechanism is based on oxidative decoloration of incorporated colorants. They have an aggressive effect on the oral mucosa, so the contact must absolutely be avoided. However, strong oxidizers also degrade structure-relevant proteins in the enamel. The content of natural macromolecules in dental enamel depends on the degree of maturation and is about 1-2 wt. % in adults. Proteins are preferably found on the surface of enamel prismatic units, but can also be integrated in the crystal structure. Composite systems of an inorganic mineral...

AI Technical Summary

Problems solved by technology

However, all these calcium phosphates are only slightly water-soluble and, for this reason, a more abrasive effect than a remineralizing one is expected.

A problem appears here with the use of concentrated phosphoric acid, which can noticeably dissolve healthy dental enamel.

It is not clear whether the salts can contribute to noticeable buildup over the relatively short exposure time.

During mixing of the components, precipitation of the poorly soluble calcium phosphates must immediately be reckoned with and it cannot be recognized why pronounced remineralization should occur, especially since the product is a toothpaste that remains in contact with the tooth surfaces for only a few minutes.

Presumably, the particles, at best, can be mechanically incorporated in appropriate cavities, which does not promise stable anchoring.

In addition, dentin is not suitable for protecting the teeth from corrosive attack.

With respect to human application, it turns out to be unfavorable that the gels must be heated before application.

In particular, smaller forms of administration quickly dry up on exposure to air and liquefaction by heating is then no longer possible without a problem.

The method does not permit application of precisely defined amounts of gel to the tooth.

In addition, the three gel layers, up to 6 mm thick, spread strongly, which leads to problems in protective systems, like braces or bandages, since space must be created here for large gel reservoirs.

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