Trehalulose-containing composition, its preparation and use

a technology of composition and trehalulose, which is applied in the field of trehalulose-containing compositions, can solve the problems of inability to produce compositions containing a high content of isomaltulose, inability to meet the needs of patients, etc., and achieves the effects of improving physical and mental performance, and reducing the risk of diabetes

Inactive Publication Date: 2010-10-21
SUDZUCKER AG MANNHEIM OCHSENFURT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0077]The present invention therefore also provides uses and methods for treating glucose or insulin metabolism-related conditions or diseases, wherein a product according to the present invention is applied in an amount suitable to achieve the desired effect to a subject in need thereof, in particular a human or animal being thereby eliciting a low insulin response and a sustained release of glucose. In the context of the present invention a glucose or insulin metabolism-related disease is selected from the group consisting of diabetes, in particular diabetes mellitus, type II, metabolism syndrome, glucose intolerance, insulin resistance, insulin sensitivity, adipositas, obesity, hyperlipidemia, cancer, liver diseases, colon cancer and overweight. The present invention provides also the teaching that the use of trehalulose or trehalulose-containing composition of the present invention increases the physical and mental performance, increases fat consumption and oxidation, controls the blood glucose and insulin levels, mobilizes free fatty acids and reduces the consumption of glycogen.
[0078]The present invention provides the advantageous teaching that trehalulose or the trehalulose-containing compositions of the present invention are capable of continuously supplying the body of the consumer, in particular the brain, nerve, blood and muscle cells with glucose for a prolonged and sustained time in a level even higher than provided by isomaltulose while simultaneously, in particular in comparison to isomaltulose, a comparable low insulin response is induced. Thus, the body is provided with a long lasting and continuous energy supply avoiding a reduction in the physical and mental performance and increasing the physical and mental endurance, condition and activity, while reducing the consumption of the glycogen reserves and supporting weight control and weight reduction.
[0079]The present invention also relates to a method for the prophylaxes and treatment of tooth diseases, in particular tooth defects, in particular caries, wherein a product or composition of the present invention is applied in an amount suitable to achieve the desired effect to a subject in need thereof. In particular, the present invention, according to which a product or a composition of the present invention is applied to a subject in need thereof, reduces the plaque formation in the mouth of the consumer. Thus, the present invention provides a method for improving the tooth health.
[0080]In a furthermore preferred embodiment the present invention relates to a method for improving the mental and / or physical performance, in particular the endurance, wherein a product or composition according to the present invention is applied in an amount suitable to achieve the desired effect to a subject in need thereof. Thus, the present invention provides in a particularly preferred embodiment a method for improving the endurance of a subject in need thereof, whereby in a particularly preferred embodiment the glycogen consumption is reduced.
[0081]In a furthermore preferred embodiment the present invention relates to a method for improving, preferably increasing, the fat oxidation of a subject in need thereof, whereby a product or composition according to the present invention is applied in an amount suitable to achieve the desired effect to a subject in need thereof. Furthermore, the present invention relates to a method for the management of body weight, wherein a composition or a product according to the present invention is applied to a subject in need thereof.
[0082]In a particularly preferred embodiment the present invention provides a method for reducing the respiratory quotient (RQ=CO2 eliminated / O2 consumed) of a patient, wherein the product or a composition according to the present invention is applied in an amount suitable to achieve the desired effect prior, during or after a physical exercise to the subject in need thereof.

Problems solved by technology

The production of trehalulose-containing compositions which comprise a high content of isomaltulose is for a number of applications, such as jelly or fruit juices, not desirable, since isomaltulose tends to crystallize out, in particular in applications in an aqueous surrounding.
Although the preparation of compositions comprising a high content of trehalulose is for some applications advantageous, it has for other applications the disadvantage of its severely inhibited crystallization capability.

Method used

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  • Trehalulose-containing composition, its preparation and use
  • Trehalulose-containing composition, its preparation and use
  • Trehalulose-containing composition, its preparation and use

Examples

Experimental program
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example 1

Preparation of Trehalulose-Containing Composition

[0091]A. Preparation of the Protaminobacter biocatalyst

[0092]Cells are rinsed off a subculture of the strain Protaminobacter rubrum (CBS 574.77) with 10 ml of a sterile nutrient substrate composed of 8 kg of thick juice from a sugar works (dry matter content 65%), 2 kg of corn steep liquor, 0.1 kg of (NH4)2HPO4 and 89.9 kg of distilled water, adjusted to pH 7.2 if required. This suspension is used as inoculum for the shaker preculture in 1 liter flasks containing 200 ml of nutrient solution of the above composition.

[0093]After an incubation time of 30 hours at 29° C., 18 liters of nutrient solution of the above composition in a 30 liter small fermenter are inoculated with, in each case, 10 flasks (total content 2 liters) and cultivated at 29° C. with 20 liters of air per minute and a stirrer speed of 350 rpm.

[0094]After the organism counts have reached above 5×109 organisms / ml, the cultivation is stopped, the cells are harvested from...

example 2

Sucrose Conversion with Various Ratios of Pseudomonas and Protaminobacter

[0109]In this example, the influence of various ratios of Pseudomonas mesoacidophila MX-45 (FERM BP 3619) and Protaminobacter rubrum CBS 574.77 on the product composition was analysed.

[0110]To prepare the sucrose-containing composition in form of an aqueous medium first solution A was prepared by preparing an aqueous solution of 1.58 g / l calcium acetate (adjusted to a pH of 5.5 with an acetic acid). Then, solution B was prepared by adding solution A up to 1 l to 1.4602 mol / l sucrose corresponding to 500 g sucrose.

[0111]Both strains of the microorganism, that means P. mesacidophila MX-45 and P. rubrum CBS 574.77, were cultivated separately as identified in example 1 A and 1 B. After the organism counts each had reached above 5×109 organism / ml, the cultivation of both microorganisms was stopped, the cells were harvested by centrifugation and pooled together in a 2% strength sodium alginate solution and immobiliz...

example 3

Preparation of Various Jellies

[0118]In the following, four recipes for jellies using as sweeteners a mixture of sucrose and glucose and four recipes using the trehalulose-containing composition of the present invention are prepared. The jellies prepared were tested comparatively in storage and TPA-analysis.

3A: Recipes

[0119]

Sample No.15678Sucrose / Glucose234TrehaluloseTrehaluloseTrehaluloseTrehalulose(240 g drySucrose / GlucoseSucrose / GlucoseSucrose / Glucose(240 g dry(325 g dry(325 g dry(250 g drysubstance,(325 g dry(325 g dry(210 g drysubstance,substance,substance,substance,41.5%)substance 56%)substance, 60%)substance, 24%)41.5%)56%)60%)24%)Pectin 13.2 g 13.2 gH&F, AF 605Citric acid, 5.0 g 6.0 g 5.0 g 7.0 ganhydrousWater290.0 g104.8 g128.8 g 39.3 g232.5 g27.0 g50.9 gSugar120.0 g162.6 g162.6 g105.0 gGlucose150.0 g203.2 g203.2 g131.3 gsyrup DE42 (approx.80% drysubstance)Trehalulose327.5 g443.5 g 443.7 g (73.3% drysubstance)Trehalulose344.7 g(73.1% drysubstance)Lemon 0.4 g 0.4 g 0.4 g 0.5 ...

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Abstract

The present invention relates to a trehalulose-containing composition, its preparation and use.

Description

TECHNICAL FIELD[0001]The present invention relates to a novel trehalulose-containing composition, a process for its preparation and methods for the use thereof.BACKGROUND OF THE INVENTION[0002]Trehalulose (1-O-α-D-glucopyranosyl-D-fructose) and isomaltulose (palatinose, 6-O-α-D-glucopyranosyl-D-fructose) are known structural isomers of sucrose. These isomers are naturally found in honey in small quantities. Both of them are known as non-cariogenic sugars. However, their physical and chemical characteristics are somewhat different, in particular in view of the fact that trehalulose is more soluble in water than isomaltulose with the consequence that their use as food ingredients is different.[0003]Both, isomaltulose and trehalulose, are also known from for instance EP 1 424 074 A1 as being heterodisaccharides, which in comparison to sucrose, show a reduced hydrolysis rate in the small intestine of human or animal consumers, thereby suggesting the provision of nutritional compositions...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7016A23L1/307A23L1/221A23L1/08C11B5/00A23K1/16A23L2/02A23L1/06A23L2/60A23L1/09C12P19/12A61P3/10A61P3/00A23L2/38A23L19/00A23L21/10A23L21/25A23L27/00A23L27/10A23L33/00A23L33/15A23L33/20
CPCA23L1/2363A23L1/30A23L1/307C12P39/00C12P19/12C12P19/18A61K31/7016A23L27/33A23L33/10A23L33/20A23L33/125A23C9/156A23L2/02A23L2/38A23L2/52C12C5/02A23V2002/00A23V2200/242A23V2200/328A23V2200/3262A23V2200/326A23V2200/332A23V2200/308A23V2200/32A23V2200/30A23V2250/156A23V2250/21A23V2250/606A23V2250/61A23V2250/62A23V2250/636A23V2250/626A23V2250/634A23V2250/64A23V2250/70A23V2250/262A23V2250/06A23V2250/0612A23V2250/1882A23V2250/214A61P1/02A61P1/16A61P19/02A61P3/00A61P3/02A61P3/04A61P35/00A61P3/06A61P5/50A61P9/10A61P3/10A23K20/00
Inventor WACH, WOLFGANGROSE, THOMASKLINGEBERG, MICHAELPETERS, SIEGFRIEDDORR, TILLMANNTHEIS, STEPHANKOWALCZYK, JORGHAUSMANNS, STEPHAN
Owner SUDZUCKER AG MANNHEIM OCHSENFURT
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