Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and food or beverage

Abstract

A neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent or an anti-obesity agent, including: at least one of protopanaxatriol, panaxatriol, protopanaxadiol and panaxadiol which are aglycons of dammarane-type saponins; and a hyperlipemia-ameliorating agent including: at least one of the neutral-fat-level-regulating agent, the cholesterol-level-regulating agent, the free-fatty-acid-level-regulating agent and the anti-obesity agent.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This is a continuation application of PCT / JP2010 / 067058, filed on Sep. 30, 2010.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent, an anti-obesity agent and an anemia-ameliorating composition, each of which contains at least one of protopanaxatriol, panaxatriol, protopanaxadiol and panaxadiol.[0004]The present invention also relates to a hyperlipemia-ameliorating agent containing at least one of the neutral-fat-level-regulating agent, the cholesterol-level-regulating agent, the free-fatty-acid-level-regulating agent and the anti-obesity agent.[0005]The present invention also relates to a uric-acid-level-reducing composition containing residues obtained by treating plants belonging to the genus Panax of the family Araliaceae with an acid.[0006]The present invention also relates t...

AI Technical Summary

Benefits of technology

[0027]The present invention aims to solve the above existing problems and achieve the following objects. Specifically, an object of the present invention is to provide: a neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent, an anti-obesity agent and a hyperlipemia-ameliorating agent, which have excellent neutral-fat-level-regulating effects, cholesterol-level-regulating effects, free-fatty-acid-level-regulating effects and anti-obesity effects and which are naturally occurring and highly safe and can be given as a food or beverage; an anemia-ameliorating composition which has excellent anemia-ameliorating effects and which is naturally occurring and highly safe and can be given as a food or beverage; a uric-acid-level-reducing composition which has excellent uric-acid-level-reducing effects, which can be given safely and effortlessly for a long time without adverse side effects, and which contributes to the prevention and amelioration of hyperuricemia; a food or beverage containing the neutral-fat-level-regulating agent, the cholesterol-level-regulating agent, the free-fatty-acid-level-regulating agent, the anti-obesity agent, the anemia-ameliorating composition and / or the uric-acid-level-reducing composition.

[0028]The present inventors conducted extensive studies to solve the above existing problems and have obtained the following findings: a neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent and an anti-obesity agent each containing at least one of protopanaxatriol, panaxatriol, protopanaxadiol and panaxadiol which are aglycons of dammarane-type saponins have excellent neutral-fat-level-regulating effects, cholesterol-level-regulating effects, free-fatty-acid-level-regulating effects and anti-obesity effects and are naturally occurring and highly safe and can be given as a food or beverage; an anemia-ameliorating composition containing panaxadiol and panaxatriol as active ingredients has excellent anemia-ameliorating effects and is naturally occurring and highly safe and can be given as a food or beverage; and a uric-acid-level-reducing composition containing as an active ingredient an acid-treated product residue obtained by hydrolyzing a plant belonging to the genus Panax of the family Araliaceae in the presence of an aqueous strong acid solution and a lower alcohol and filtrating the plant with the addition of water has excellent uric-acid-level-reducing effects, can be given safely and effortlessly for a long time without adverse side effects, and contributes to the prevention and amelioration of hyperuricemia. The present invention has been accomplished on the basis of these findings.

[0050]The present invention can provide: a neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent, an anti-obesity agent and a hyperlipemia-ameliorating agent, which have excellent neutral-fat-level-regulating effects, cholesterol-level-regulating effects, free-fatty-acid-level-regulating effects and anti-obesity effects and which are naturally occurring and highly safe and can be given as a food or beverage; an anemia-ameliorating composition which has excellent anemia-ameliorating effects and which is naturally occurring and highly safe and can be given as a food or beverage; a uric-acid-level-reducing composition which has excellent uric-acid-level-reducing effects, which can be given safely and effortlessly for a long time without adverse side effects, and which contributes to the prevention and amelioration of hyperuricemia; and a food or beverage containing the neutral-fat-level-regulating agent, the cholesterol-level-regulating agent, the free-fatty-acid-level-regulating agent, the anti-obesity agent, the anemia-ameliorating composition and / or the uric-acid-level-reducing composition. These can solve the above existing problems and achieve the above objects.

Problems solved by technology

In addition, arterial sclerosis deteriorates the condition of high blood pressure and causes kidney diseases and other diseases.

However, there is difficulty in selecting optimal methods for diet restriction and exercise therapy, and those receiving such therapies have to continuously and constantly address them.

This drug has cholesterol-regulating effects but problematically involves adverse side effects such as hepatic disorder, rhabdomyolysis, an increase in creatine kinase (CPK) level, diarrhea and stomachache.

These compounds, however, do not have satisfactory preventing and ameliorating effects on hyperlipemia.

These plants, however, do not have satisfactory effects.

In general, the total number of blood cells in blood, especially the number of hemoglobin, decreases with the progress of anemia, so that the ability to transport oxygen decreases to cause lack of oxygen in tissues.

However, in the method for ameliorating anemia by intake of foods, satisfactory effects cannot be expected without taking in iron-rich foods simultaneously with nutrients such as vitamins C, B6 and B12 and folic acid.

Among pharmaceutical drugs prescribed for anemia symptoms, Ferromia, Ferrum, Fero-Gradumet, TETUCUR, Slow-Fe, Methycobal, Foliamin and Pydoxal can cause, after administration, adverse side effects such as vomiting, nausea, anorexia, stomach discomfort, stomachache, diarrhea, constipation rash, urticaria and itchy.

However, there is no previous report about use of panaxadiol (PD) and panaxatriol (PT) for an anemia-ameliorating composition, which are formed after the side chains of the aglycons have been cyclized.

Furthermore, gouty arthritis caused by hyperuricemia has recently been a problem.

However, when the balance between the amount of uric acid produced and the amount of uric acid excreted is lost due to certain factors (e.g., eating habits, alcohol drinking, stress, reduction in kidney functions, effects of drugs and genetic factors), the uric acid level in the body increases excessively, potentially leading to hyperuricemia.

When hyperuricemia is not treated for a long time, an excessive amount of uric acid salts forms their crystals around joints and cartilage tissue, inducing gouty arthritis.

Also, after administration, they cause adverse side effects such as fever, rash, hepatic disorder and abnormalities in kidney functions.

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