Hydrogel formulation for dermal and ocular delivery

a technology of ocular delivery and hydrogel formulation, which is applied in the field of polyalkylene oxide hydrogel composition, can solve the problems of eye, skin and respiratory system damage, incapacitation, cell death, and eye damage, and achieve the effects of reducing the risk of eye damage, and reducing the effect of ocular oxygen absorption
US20140086975A1Inactive Publication Date: 2014-03-27RUTGERS THE STATE UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
RUTGERS THE STATE UNIV
Publication Date
2014-03-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (SM), nitrogen mustard (NM) or half mustard (2-chloroethyl ethyl sulfide (CEES)) are also disclosed.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] The present invention claims priority benefit under 35 U.S.C. §119(e) of U.S. Provisional Patent Application Ser. No. 61 / 393,653, filed Oct. 15, 2010, the disclosure of which is incorporated herein by reference.STATEMENT REGARDING FEDERALLY FUNDED RESEARCH

[0002] This invention was made with government support under Grant U54AR055073 awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Accordingly, the U.S. Government has certain rights in this invention.BACKGROUND OF THE INVENTION

[0003] 1. Field of the Invention

[0004] The present invention relates to compositions of polyalkylene oxide hydrogels, as well as methods of making and using the hydrogel for wound healing applications. More particularly, embodiments relate to compositions comprising functionalized polyethylene glycol (PEG) in new and useful configuration hydrogels.

[0005] 2. Description of the Related Art

[0006] Vesicants such as sulfur mustard, nitrogen ...

Claims

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