Composition having lactobacillus plantarum strain gmnl-662 for promoting bone regrowth

Inactive Publication Date: 2018-08-23
GENMONT BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0015]In one embodiment of the present invention,

Problems solved by technology

Osteoporosis is a kind of systemic skeletal disease, which includes bone loss and bone tissue microstructure deterioration, resulting in bone fragility and risk of fracture.
Once the bone resorption is over bone formation, bone loss will caused, and finally result in osteoporosis.
The drugs that control osteoporosis are accompanied by some side effects.
It is found in the clinical trials that the use of drugs in combination has no addition effect, but will resist each other, or increase the incidence or strength of the side effects.
Therefore, the current guidelines for vari

Method used

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  • Composition having lactobacillus plantarum strain gmnl-662 for promoting bone regrowth
  • Composition having lactobacillus plantarum strain gmnl-662 for promoting bone regrowth
  • Composition having lactobacillus plantarum strain gmnl-662 for promoting bone regrowth

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[0019]The structure and the technical means adopted by the present invention to achieve the above and other objects can be best understood by referring to the following detailed description of the preferred embodiments. Furthermore, if there is no specific description in the invention, singular terms such as “a”, “one”, and “the” include the plural number. For example, “a compound” or “at least one compound” may include a plurality of compounds, and the mixtures thereof. If there is no specific description in the invention, “%” means “weight percentage (wt %)”, and the numerical range (e.g. 10%-11% of A) contains the upper and lower limit (i.e. 10%≤A≤11%). If the lower limit is not defined in the range (e.g. less than, or below 0.2% of B), it means that the lower limit may be 0 (i.e. 0%≤B≤0.2%). The proportion of “weight percent” of each component can be replaced by the proportion of “weight portion” thereof. The abovementioned terms are used to describe and understand the present i...

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Abstract

A composition having Lactobacillus Plantarum strain GMNL-662 for promoting bone regrowth is provided. The Lactobacillus Plantarum strain GMNL-662 has an ability to promote the expression of osteogenic genes, inhibit the expression of osteoclast related genes, and promote the expression of osteogenesis-related cytokine TGF-β, so that the bone loss is improved.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of the filing date of Taiwan patent application No. 106105625, filed on Feb. 20, 2017, the disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to a composition including Lactobacillus Plantarum strain GMNL-662 for promoting bone regrowth, and in particular relates to a composition including Lactobacillus Plantarum strain GMNL-662 which has an ability of increasing the expression of osteogenic genes.BACKGROUND OF THE INVENTION[0003]Osteoporosis is a kind of systemic skeletal disease, which includes bone loss and bone tissue microstructure deterioration, resulting in bone fragility and risk of fracture.[0004]During bone remodeling process, the bone formation of osteoblasts and bone resorption of osteoclast maintain the dynamic balance of bone tissue together. Once the bone resorption is over bone formation, bone loss will caused, and finally re...

Claims

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Application Information

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IPC IPC(8): A61K35/747A23L33/135
CPCA61K35/747A23Y2220/67A23V2002/00A23L33/135C12N1/20C12R2001/25C12N1/205A23V2400/169
Inventor CHEN, YI-HSINGTSAI, WAN-HUACHOU, CHIA-HSUANLIN, CHI CHIEN
Owner GENMONT BIOTECH
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