The invention is a telepresence interactive operation wheelchair, which is composed of an ordinary electric wheelchair, a telepresence module, a user interface for directly touching live real-time video images, and a semi-autonomous navigation module, and belongs to the field of nursing equipment. The telepresence module acquires live real-time video images, transmits the live real-time video images to the operator's palm computer in the remote operation space through the network, and forms a user interface TIUI for touching live real-time video images. Through TIUI, the operator uses touch gestures such as touch click and touch drag to directly touch the wheelchair in the live real-time video image to complete the interactive operation of the wheelchair. The present invention can give the wheelchair operator an immersive user experience, as if the operator is operating the wheelchair on the spot; with the help of mobile computing devices such as handheld computers and smart hands, the wheelchair can be interactively operated anytime and anywhere, and through the telepresence module Accompany wheelchair users.