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(-)-epigallocatechin gallate-magnesium complex solid dispersion and its prepn and application

A technology of solid dispersion and complex, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of single drug application and unsatisfactory curative effect, and achieve The preparation method is simple, the single applicable disease of the drug is overcome, and the effect of pharmacological action is improved

Active Publication Date: 2007-11-21
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a kind of EGCG-magnesium complex solid dispersion with remarkable curative effect and wide application in view of the common problems of single drug application and unsatisfactory curative effect in the existing senile disease treatment

Method used

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  • (-)-epigallocatechin gallate-magnesium complex solid dispersion and its prepn and application
  • (-)-epigallocatechin gallate-magnesium complex solid dispersion and its prepn and application
  • (-)-epigallocatechin gallate-magnesium complex solid dispersion and its prepn and application

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Embodiment 1

[0020] The preparation of embodiment 1 EGCG-magnesium complex solid dispersion

[0021] EGCG, with a purity of 99.6%, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Pharmacy, Sun Yat-sen University. Polyvinylpyrrolidone PVP-k30 (referred to as PVP), imported and repackaged, provided by Guangzhou Chemical Reagent Wholesale Department.

[0022] Dissolve 10 grams of EGCG in 50 ml of deionized water, add magnesium acetate solution dropwise (the molar ratio of EGCG and magnesium acetate is 1:3), stir while adding dropwise, protect with nitrogen, add saturated magnesium hydroxide solution dropwise, adjust EGCG- The pH of the magnesium complex liquid is 7.0, and the EGCG-magnesium complex precipitate is obtained. After the precipitation is complete, centrifuge at 5000rpm for 5min, collect the precipitate, resuspend it with 80ml of deionized water, centrifuge at 5000rpm for 5min, collect the precipitate, and then use 80ml Suspend in deio...

Embodiment 2

[0023] The preparation of embodiment 2 EGCG-magnesium complex solid dispersion

[0024] EGCG, with a purity of 99.6%, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Pharmacy, Sun Yat-sen University. Polyvinylpyrrolidone PVP-k30 (referred to as PVP), imported and repackaged, provided by Guangzhou Chemical Reagent Wholesale Department.

[0025] Dissolve 10 grams of EGCG in 50 ml of deionized water, add magnesium acetate solution (EGCG: magnesium acetate, molar ratio = 1: 3)) dropwise, stir while adding, pass nitrogen protection, add saturated magnesium hydroxide solution dropwise, adjust The pH of the EGCG-magnesium complex liquid was 7.2, and the EGCG-magnesium complex precipitate was obtained. After the precipitation was complete, centrifuge at 5000rpm for 5min, collect the precipitate, resuspend it with 80ml of deionized water, centrifuge at 5000rpm for 5min, collect the precipitate, and then Suspend with 80ml of deionized water...

Embodiment 3

[0026] The preparation of embodiment 3 EGCG-magnesium complex solid dispersion

[0027] EGCG, with a purity of 99.6%, was provided by the Laboratory of Traditional Chinese Medicine and Marine Medicine, School of Pharmacy, Sun Yat-sen University. Polyvinylpyrrolidone PVP-k30 (referred to as PVP), imported and repackaged, provided by Guangzhou Chemical Reagent Wholesale Department.

[0028] Dissolve 10 grams of EGCG in 50 ml of deionized water, add MgCl dropwise 2 Solution (EGCG: MgCl 2 , molar ratio = 1: 3), stirring while adding dropwise, nitrogen protection, dropwise adding saturated magnesium hydroxide solution, adjusting the pH of the EGCG-magnesium complex liquid to 7.8, and obtaining the EGCG-magnesium complex precipitate, to Complete precipitation, centrifuge at 5000rpm for 5min, collect the precipitate, re-suspend with 80ml of deionized water, centrifuge at 5000rpm for 5min, collect the precipitate, resuspend with 80ml of deionized water, and centrifuge at 5000rpm for...

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Abstract

The present invention discloses one kind of (-)-epigallocatechin gallate (EGCG)-Mg complex solid dispersion and its preparation and application. The EGCG-Mg complex solid dispersion contains EGCG-Mg complex and PVP-k30 in the weight ratio of 1 to 0.5-15, optimally 1 to 2-8. The preparation process of the EGCG-Mg complex solid dispersion includes dissolving EGCG in deionized water, dropping Mg salt solution while stirring and introducing protecting nitrogen, dropping saturated magnesium hydroxide solution to regulate liquid pH value to 7.0-8.0 to obtain EGCG-Mg complex precipitate, washing with deionized water, centrifuging to collect precipitate and suspending the precipitate with deionized water; dropping PVP-k30 into EGCG-Mg complex while stirring and introducing protecting nitrogen, high pressure homogenizing, filtering, and spray drying to obtain the EGCG-Mg complex solid dispersion, which is used in treating senile diseases in high curative effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a (-)-epigallocatechin gallate-magnesium complex solid dispersion, a preparation method and a medical application thereof. Background technique [0002] (-)-Epigallocatechin-3-gallate [(-)-Epigallocatechin-3-gallate, referred to as EGCG] has good free radical scavenging, anti-oxidation, anti-mutation, anti-aging, anti-radiation, anti-virus, anti- Anti-cancer, lowering blood fat and cholesterol, anti-atherosclerosis, antibacterial, lowering blood sugar, lowering blood pressure and other health care and pharmacological effects. [0003] However, due to the instability of EGCG, it is very easy to absorb moisture, oxidize, have low bioavailability, poor absorption, and cause irritation to the gastrointestinal tract. Long-term use will reduce the content of metals such as iron in the body and other shortcomings limit the application of EGCG. Simple tea polyphenols and metal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61K47/32A61K9/00A61P3/10A61P3/06A61P25/28A61P9/10A61P9/06A61P1/16A61P35/00A61P39/06
Inventor 许东晖梅雪婷许实波
Owner SUN YAT SEN UNIV