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Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers

A technology of bilacilidin and bilirubin, which is applied in the field of preparation of the medicinal ingredient cucurbitin, and can solve problems such as reports on the application of cucurbitin that have not yet been found

Active Publication Date: 2009-02-25
KUNMING LONGJIN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no report on the application of porphyrin in anticancer drugs

Method used

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  • Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers
  • Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers
  • Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers

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Embodiment 1

[0056] Embodiment 1: Take 5kg of the bottom of the Luoguo in Qiaojia County, Yunnan, grind it into medium powder, put it into a percolation container, add 24 times the amount of acetone to soak for 48 hours at 15-25 ° C, and then carry out percolation according to the Chinese Pharmacopoeia percolation method , recover the percolation liquid, mix the extract with an equal amount of silica gel, dry at 50-70°C, put it on a silica gel column, use chloroform: methanol as the eluent for gradient elution, and collect the eluate at a concentration of 3-5% methanol After recovery, the crude product can be obtained, and recrystallized several times with methanol to obtain columnar crystals with a melting point of 226-228°C and a purity of 98.98% by HPLC analysis. As shown in Figure 1, it was confirmed to be bilbacetin by ultraviolet, infrared, nuclear magnetic resonance, and mass spectrometry four-spectrum analysis.

[0057] Using the above-mentioned pectin as a monomer component, accor...

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Abstract

Production of medicinal component snow bile pigment and its usage for preparing medicines in treatment of cancers are disclosed. The process is carried out by taking snow bile plant tuber, crushing, taking acetone 18-26 proportion as solvent, extracting by diacolation method, recovering extract in water-bath kettle at 60-75 degree to obtain extractive, adding extractive into silica gel 1-2 proportion, drying to obtain silica-gel column, gradient eluting by ethanol or chloroform with volume concentration 2-10%, recovering eluent to obtain coarse product, heating while dissolving for ethanol or alcohol in water bath, filtering, lowering to room temperature, re-crystallizing to obtain prism crystal with purity above 98%. It can be used to prepare medicines in treatment of hepatocarcinoma, lung cancer, gastric carcinoma, laryngeal cancer and leukemia.

Description

technical field [0001] The invention relates to a preparation method of the medicinal ingredient gentamicin and its new application in the preparation of medicines for treating cancer. Background technique [0002] Echobilisin is a mixture consisting of escobilin and escobilin. It was first isolated from the root of Hemsleya amalils Diels by Chen Weixin et al. (Acta Chemica Sinica, 1975, 33(1), 5). Hemsleya amalils was identified as 19-carbo-9β-formazan base-10 -3 - Hydrogen-2β,3 , 16 , 20,25-pentahydroxy Δ5 lanosterene-11,20-diketone-25-acetate (IIa), 23.24-cc dihydro-25-acetate of cucurbitacin F (Ic), B It is the 23, 24-dihydro compound of cucurbitacin F (Ic), two new compounds, and the development of ichorin tablets, which was included in the Yunnan Provincial Drug Standards in 1974, for the treatment of bacillary dysentery and enteritis , Tracheitis, acute tonsillitis. [0003] In order to find plant resources for extracting pectin, some scholars have carried ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A61K31/575A61P35/00
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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