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Coated magnolia fargesii volatile oil nano liposome nasal drops

A technology of nano-liposomes and nasal drops, which can be used in liposome delivery, plant raw materials, respiratory diseases, etc. It can solve the problems of no patent report of magnolia volatile oil liposomes, etc., so as to improve the effective utilization rate and drug absorption Rapid, easily absorbed effect

Inactive Publication Date: 2009-03-11
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there is no patent report about the volatile oil liposome of magnolia at home and abroad

Method used

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  • Coated magnolia fargesii volatile oil nano liposome nasal drops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of Nanoliposome Nasal Drops Coated with Magnolia Magnolia Volatile Oil (1)

[0040] 200mg soybean lecithin, 750mg magnolia volatile oil, 100mg cholesterol, 0.2mg sodium cholate, 1mg collagen, dissolved in 20ml of 2:1 methanol / chloroform mixed solvent. Constant temperature at 38°C, evaporate under reduced pressure to form a lipid film, add 20ml of phosphate buffer to shake and dissolve, adjust the pH value to 5.5, add 10mg of stearic acid amine, 0.05mg of polysorbate 80, and obtain a multilocular liposome dispersion. Ultrasonic treatment at an ultrasonic temperature of 10°C and an ultrasonic frequency of 200 Hz in an ice-water bath for 20 minutes, filtering through a 0.15 μm microporous membrane to form a uniform monolayer liposome suspension, adding 8.5 mg of phosphatidylglycerol to the filtrate to prepare Nasal administration formulations. The average particle size of liposomes encapsulating the drug carrier in the suspension was determined to be 73nm, and...

Embodiment 2

[0042] Preparation of Nanoliposome Nasal Drops Coated with Magnolia Magnolia Volatile Oil (2)

[0043] 200mg egg yolk lecithin, 330mg magnolia volatile oil, 66mg cholesterol, 0.01mg sodium deoxycholate, 10mg vitamin A acetate, dissolved in a mixed solvent of 30ml methanol. Constant temperature at 28°C, evaporate under reduced pressure to form a lipid film, add 20ml of phosphate buffer to shake and dissolve, adjust the pH value to 7.0, add 100mg of diacetyl phosphate, 0.1mg of methylparaben, and obtain a multilocular liposome dispersion . Ultrasonic treatment at an ultrasonic temperature of 1°C and an ultrasonic frequency of 600 Hz in an ice-water bath for 10 minutes, filtered through a 0.15 μm microporous membrane to form a uniform monolayer liposome suspension, and adding 4 mg of phosphatidic acid to the filtrate to prepare nasal administration pharmaceutical preparations. The average particle size of the liposomes encapsulating the drug carrier in the suspension was determ...

Embodiment 3

[0045] Preparation of Nanoliposome Nasal Drops Coated with Magnolia Magnolia Volatile Oil (3)

[0046]Dissolve 200mg soybean lecithin, 1600mg magnolia volatile oil, 200mg cholesterol, 5mg Triton-100, 5mg vitamin E in 40ml chloroform mixed solvent, evaporate under reduced pressure at 65°C to form a lipid film, add 20ml phosphate buffer to shake and dissolve, and adjust the pH value 7.5, add 20 mg of stearic acid amine, 50 mg of diacetyl phosphate, and 0.1 mg of phenylparaben methyl ester to obtain a multilocular liposome dispersion, and conduct ultrasonic treatment in an ice-water bath for 1 minute at an ultrasonic temperature of 5 ° C and an ultrasonic frequency of 1000 Hz. After filtering through a 0.15 μm microporous membrane to form a uniform monolayer liposome suspension, 2 mg stearylamine was added to the filtrate to prepare a nasal administration preparation. The average particle size of liposomes encapsulating the drug carrier in the suspension was determined to be 66nm...

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Abstract

The present invention relates to a kind of covered magnolia flower-bud volatile oil nano liposome nose drops. Its preparation method includes the following steps: (a), mixing magnolia flower-bud volatile oil, phospholipids, cholesterol, antioxidant and liposome membrane regulating agent and dissolving them in solvent; (b), making the mixed solvent obtained by step a undergo the process of constant temperature reduced pressure evaporation treatment; (c), adding the lipid membrane obtained by step b into buffer solution, making oscillation and salvation, regulating pH value and adding auxiliary material; (d), making the liposome dispersing solution obtained by step c undergo the process of ice-water bath ultrasonic treatment and be passed through microporous filter membrane to make filtration; and (e), filtering the liposome mixed suspension solution obtained by steps d and adding the stabilizing agent into filtrate so as to obtain the invented nose drops.

Description

technical field [0001] The invention relates to a nasal drop, in particular to a nano liposome nasal drop coated with magnolia volatile oil. Background technique [0002] Magnolia volatile oil contains a variety of components, which in addition to the main active ingredient eucalyptol, also contains α-pinene, linalool, geraniol, α-terpineol, geraniol, farnesol, clove oil Phenols, coumarins, lignans and other components. Magnolia magnolia nature and flavor are pungent, warm, have divergent wind-cold, the effect of opening the nose. Extracted essential oil from magnolia flower—Magnolia volatile oil has many targets for the treatment of allergic rhinitis. It can affect allergic rhinitis through multiple links such as antihistamine, anti-allergy, anti-inflammation, and protection of mast cells. The treatment of allergic rhinitis is the synergistic effect of several mechanisms, so that better therapeutic effect can be obtained. [0003] Liposome is a term describing various ar...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K36/575A61P11/04A61K133/00
Inventor 吴敏王雪梅张雄
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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