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Composite amino acid freeze dried powder injection and its preparation process

A technology for compound amino acid and needle injection, which is applied in the field of compound amino acid freeze-dried powder injection and its preparation, and can solve the problems of failure to prepare compound amino acid freeze-dried powder injection, difficult solution clarity, poor solubility of compound amino acid, etc. , achieve the effects of improving protein absorption barriers, good solubility and clarity, and low requirements for packaging materials

Inactive Publication Date: 2009-03-18
武汉同源药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. Due to the continuous contact with the rubber stopper of the infusion bottle, the Chinese medicinal liquid for large infusions makes the clarity of the solution difficult to pass
[0007] 3. Xylitol is used as the isotonic agent of the large infusion solution, which has limitations in clinical use
[0008] Based on the above-mentioned prior art and existing problems, although those skilled in the art may think of combining the existing freeze-dried powder injection technology of other medicines to propose the idea of ​​preparing the freeze-dried powder injection of the compound amino acid related to the present invention, due to the preparation of freeze-dried powder Powder injection requires a relatively low amount of water, and compound amino acids have poor solubility in this amount of water, so far it has not been possible to prepare compound amino acid freeze-dried powder injections that meet the medicinal requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Compound amino acid freeze-dried powder injection, each 1000 bottles contains L-arginine hydrochloride 289g, L-leucine 379g, L-isoleucine 170g, L-lysine hydrochloride 333g, L-phenylalanine 283g , L-threonine 197g, L-valine 136g, L-methionine 106g, glycine 324g, L-alanine 188g, L-proline 100g, L-tyrosine 11g, L-serine 67g, L-aspartic acid 115g, L-glutamic acid 197g, L-histidine hydrochloride 246g, L-tryptophan 39g, L-cysteine ​​hydrochloride 44g, sodium bisulfite 50g and sodium hydroxide 12.6 grams.

[0025] Preparation of compound amino acid freeze-dried powder injection:

[0026] 1. Take 18 kinds of amino acids, sodium bisulfite and sodium hydroxide according to the composition of the above compound amino acid freeze-dried powder injection, and take another 96,000 grams of water for injection.

[0027] 2. Take 4 / 5 of the total amount of the above-mentioned water for injection, filter it with a 0.45um microporous membrane, heat to boiling, stop heating, and add sodium...

Embodiment 2

[0031] Compound amino acid freeze-dried powder injection, each 1000 bottles contains compound amino acid freeze-dried powder injection, each 1000 bottles contains L-arginine hydrochloride 299g, L-leucine 369g, L-isoleucine 180g, L-hydrochloride Lysine 323g, L-phenylalanine 293g, L-threonine 187g, L-valine 146g, L-methionine 96g, glycine 334g, L-alanine 178g, L-proline 110g, L-tyrosine 1g, L-serine 77g, L-aspartic acid 105g, L-glutamic acid 207g, L-histidine hydrochloride 236g, L-tryptophan 49g, L-cysteine ​​hydrochloride Acid 34g and sodium bisulfite 60g.

[0032] Preparation of compound amino acid freeze-dried powder injection:

[0033] 1. Take 18 kinds of amino acids and sodium bisulfite according to the composition of the above compound amino acid freeze-dried powder injection, and take another 33,000 grams of water for injection.

[0034] 2. Take 4 / 5 of the total amount of the above-mentioned water for injection, filter it with a 0.45um microporous membrane, heat it to b...

Embodiment 3

[0039] Compound amino acid freeze-dried powder injection, each 1000 bottles contains L-arginine hydrochloride 279g, L-leucine 389g, L-isoleucine 160g, L-lysine hydrochloride 343g, L-phenylalanine 273g , L-threonine 207g, L-valine 126g, L-methionine 116g, glycine 314g, L-alanine 198g, L-proline 90g, L-tyrosine 21g, L-serine 57g, L-aspartic acid 125g, L-glutamic acid 187g, L-histidine hydrochloride 256g, L-tryptophan 29g, L-cysteine ​​hydrochloride 54g, sodium bisulfite 40g and sodium hydroxide 14 grams.

[0040] Preparation of compound amino acid freeze-dried powder injection:

[0041] 1. Take 18 kinds of amino acids, sodium bisulfite and sodium hydroxide according to the composition of the above compound amino acid freeze-dried powder injection, and take another 65,000 grams of water for injection.

[0042] 2. Take 4 / 5 of the total amount of the above-mentioned water for injection, filter it with a 0.45um microporous membrane, heat to boil, stop heating, and add sodium hydro...

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PUM

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Abstract

The invention relaets to a compound amino acid freeze-dried powder injection, which comprises L-arginine hydrochloride, L-histidine hydrochloride, L-leucine, L-isoleucine, L-lysine hydrochloride, L-phenylalanine, L-threonine, L-valine, L-methionine, L-tryptophan, glycine, L-alanine, L-proline, L-tyrosine, L-serine, L-cysteine hydrochloride, L- aspartic acid, L-glutamic acid and sodium bisulphate. Its preparing process is also disclosed in the invention.

Description

technical field [0001] The invention relates to a compound amino acid freeze-dried powder injection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Compound amino acid preparation is a new type of compound preparation. The various amino acids it contains include essential, non-essential and semi-essential amino acids. salts, sugars and trace elements. Such as the compound amino acid preparation mainly used in the digestive system Oral amino acid capsule (Moriumin Sorte): This product contains 18 kinds of crystalline amino acids, multivitamins and special nutrients. Oral administration can provide enough essential amino acids for the human body, promote the synthesis of the body's protein, especially the synthesis of albumin, and improve the body's own immunity. Clinically, it can be used for metabolic disorders caused by liver and kidney insufficiency, protein deficiency caused by various diseases, functional fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K9/19A61P3/02
Inventor 周恩惠
Owner 武汉同源药业有限公司
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