Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing amino acid and lactic acid copolymer

A technology of lactic acid copolymerization and amino acid, applied in the field of preparation of biodegradable materials, can solve the problems of large amount of reagents, time-consuming, complex process, etc., and achieve the effect of reducing synthesis cost, rapid synthesis and easy product

Inactive Publication Date: 2007-08-29
SOUTH CHINA NORMAL UNIVERSITY
View PDF0 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the rather cumbersome preparation and purification process of cyclic monomers such as morpholine-2,5-dione and lactide makes the entire preparation route of amino acid and lactic acid copolymer tedious, and the amount of solvent and reagent used is large, resulting in the overall existence of Unfavorable economic factors such as complex process, time-consuming, and high consumption

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Using D, L-LA and glycine as raw materials, mix them evenly according to the mass ratio m(D, L-LA):m(glycine) = 98:2, and obtain the intermediate Body I, adding catalyst zinc oxide (mass percentage is 0.6% of Intermediate I), melt polycondensation at a temperature of 165° C. and a pressure of 70 Pa for 10 h. After the reaction, the product was purified by dissolving in chloroform at room temperature, precipitated by methanol, and dried in vacuum to obtain a white powdery amino acid and lactic acid copolymer. The structure of the copolymer was confirmed by polymer characterization methods such as infrared spectroscopy, hydrogen nuclear magnetic resonance spectroscopy, and gel permeation chromatography. , Intrinsic viscosity [η] 0.8458dL / g, amino acid and lactic acid copolymer synthesized by this method can successfully prepare Fuliping slow-release microspheres.

Embodiment 2

[0022] Use D, L-LA, and alanine as raw materials, mix them evenly according to the mass ratio m(D, L-LA):m(alanine)=90:10, and remove water after prepolymerization at 130°C, 4000Pa, and 12h Intermediate I was obtained after treatment, adding catalyst zinc lactate (0.5% by mass of Intermediate I), controlled temperature 160°C and pressure 80Pa, and reacted for 20h. After the reaction, the product was dissolved in chloroform, purified by methanol precipitation, and vacuum-dried to obtain a white powdery amino acid and lactic acid copolymer. The structure of the copolymer was confirmed by polymer characterization methods such as infrared spectroscopy, hydrogen nuclear magnetic resonance spectroscopy, and gel permeation chromatography. The characteristics Viscosity [η] 0.5236dL / g, amino acid and lactic acid copolymer synthesized by this method successfully prepared 5-fluorouracil sustained-release microspheres.

Embodiment 3

[0024] Using L-LA and tyrosine as raw materials, mix them uniformly according to the mass ratio m(L-LA):m(tyrosine)=50:50, and obtain intermediate Body I, adding catalyst ferrous lactate (mass percentage is 0.1% of Intermediate I) at a temperature of 165 ° C and a pressure of 90 Pa, melt polycondensation for 3 hours. After the reaction, the product was dissolved, precipitated and purified, and vacuum-dried to obtain a white powdery amino acid and lactic acid copolymer. The structure of the copolymer was confirmed by polymer characterization methods such as infrared spectroscopy, hydrogen nuclear magnetic resonance spectroscopy, and gel permeation chromatography. The intrinsic viscosity [ η] 0.3085dL / g, can be applied to the preparation of ciprofloxacin drug microspheres.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Intrinsic viscosityaaaaaaaaaa
Intrinsic viscosityaaaaaaaaaa
Intrinsic viscosityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a manufacture method for amino acid and lactic acid copolymer used for medicine slow release that uses alpha-amino acid and lactic acid as raw material. It adopts the method of fusion copolymerization condensation to shorten compounding time. And is easy to operate and is benefit to decrease the compound cost of the biology degradation.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable material used for drug sustained release, in particular to a preparation method of amino acid and lactic acid copolymer. technical background [0002] Amino acid and lactic acid copolymers are one of the biodegradable materials, which can be applied to drug sustained release, tissue engineering, etc. In the traditional synthesis method of amino acid and lactic acid copolymers, ring-opening homopolymerization of morpholine-2,5-dione is usually performed, or morpholine-2,5-dione and cyclic monomer lactide Preparation by ring-opening copolymerization [Int'Veld P J A, Dilstra P J, Vanlochem J H, Feijen J.Synthesis of alternate polydepsipeptides by ring-opening polymerization of morpholine-2,5-dione derivatives[J]. Makromol Chem, 1990, 191(8) : 1813~1825; Zhang Guodong, Yang Jiyuan, Feng Xinde. Research Progress of Polylactic Acid [J]. Progress in Chemistry, 2000, 12(1): 89~102; Tang Zhirong,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G63/08C08G63/78C08G63/685
Inventor 汪朝阳侯晓娜
Owner SOUTH CHINA NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com