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Method for producing citric acid bismuth, oxalic acid bismuth and bismuth subsalicylate by electrolyzing active metal bismuth

A technology of electrolytic activation and bismuth citrate, applied in the field of producing bismuth citrate, bismuth oxalate, and bismuth subsalicylate, can solve the problems of environmentally harmful nitrogen oxides, long process flow, residual nitrate, etc., and achieve the elimination of nitrogen oxides. Emission of pollutants, high product purity, and the effect of simplifying the production process

Inactive Publication Date: 2007-09-26
SUZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the advantage of fast reaction speed and can be mass-produced, but the process also has the following defects: 1. bismuth nitrate needs to be obtained by dissolving bismuth with nitric acid, and this process produces nitrogen oxides harmful to the environment
2. The process process is longer
3. Residual nitrate radicals in the product will affect the purity
Using the chemical reactivity of ultrafine metal bismuth, that is, using active bismuth to directly react with organic acids to prepare three drugs, bismuth citrate, bismuth oxalate, and bismuth subsalicylate, has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] In a 100mL beaker, use 50mL sodium chloride aqueous solution (1% concentration by mass) as electrolyte, refined bismuth (99.99%) sheet as anode (1cm×1cm), platinum sheet (99.50%) as cathode (1cm×1cm) 1cm), through direct current electrolysis, current 0.5A. After 45 minutes, the electrolysis was stopped, and black spongy ultrafine bismuth was obtained at the cathode with a particle size distribution of 40-150nm. Take out the electrode, scrape ultrafine bismuth from the cathode into 25mL citric acid aqueous solution (25% by mass), stir vigorously until the black powder disappears, and filter the reaction mixture to obtain a white precipitate. The precipitate was washed with deionized water and then dried to obtain product 1, as shown in Table 1 below.

Embodiment 2

[0046] In a 100mL beaker, use 50mL sodium chloride aqueous solution (mass percentage concentration: 1%) as the electrolyte, use refined bismuth (99.99%) as the anode (1cm × 1cm), and nickel (99.50%) as the cathode (1cm × 1cm), through direct current electrolysis, current 0.5A. After 45 minutes, the electrolysis was stopped, and black spongy ultrafine bismuth was obtained at the cathode with a particle size distribution of 40-150nm. Take out the electrode, scrape off the ultrafine bismuth from the cathode into 25mL oxalic acid aqueous solution (9% by mass), stir vigorously until the black powder disappears, filter the reaction mixture to obtain a white precipitate, wash the precipitate with deionized water, and then dry it. Get product two, see table 1 below.

Embodiment 3

[0048] In a 100mL beaker, use 50mL potassium chloride aqueous solution (1% by mass) as the electrolyte, use refined bismuth (99.99%) as the anode (1cm×1cm), and platinum (99.50%) as the cathode (1cm×1cm). 1cm), through direct current electrolysis, current 0.5A. After 45 minutes, the electrolysis was stopped, and black spongy ultrafine bismuth was obtained at the cathode with a particle size distribution of 40-150nm. Remove the electrodes and scrape the ultrafine bismuth from the cathode into the electrolyte. Directly add 25mL salicylic acid solution (mass percentage concentration is 15%, ethanol / water mixed solvent (volume ratio is 1: 1)) in this beaker, stir vigorously until black powder disappears, filter reaction mixture and obtain white precipitation, will The precipitate was washed with deionized water and then dried to obtain product 3, as shown in Table 1 below.

[0049] The characterization of above embodiment product:

[0050] The obtained product was subjected to ED...

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Abstract

The invention discloses a manufacturing method of bismuth citrate, bismuth oxalate and bismuth subsalicylate through electrolyzing and activating metal bismuth, which is characterized by the following: making new hyperfine bismuth with grain size at 20-350nm; reacting the strong hyperfine bismuth and organic acid to produce the product; simplifying the technique; reducing cost; improving impurity effectively without polluting the environment.

Description

technical field [0001] The invention relates to a method for producing bismuth citrate, bismuth oxalate and bismuth subsalicylate, in particular to a method for directly producing bismuth citrate, bismuth oxalate and bismuth subsalicylate through active bismuth. This method does not use nitric acid in the production process, and is an environmentally friendly and economical method for synthesizing bismuth medicine. Background technique [0002] Bismuth has a wide range of uses in the field of medicine. Because the metal activity of bismuth is not strong, it cannot directly react with organic acids. In the past, bismuth citrate, bismuth oxalate and bismuth subsalicylate were usually produced by bismuth oxide method, bismuth hydroxide method and bismuth nitrate method. The bismuth oxide method generally uses bismuth oxide as a raw material, adding other strong acidic substances to dissolve bismuth oxide, and then further reacting with organic acids to obtain product precipita...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C55/07C07C65/10C07C51/41C25C1/22
CPCY02P10/20
Inventor 顾建胜李栋强陆文娟
Owner SUZHOU UNIV
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