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Composition for preventing and curing diabetes

A composition, plant technology, applied in the direction of drug combination, application, metabolic disease, etc., can solve problems without providing scientific basis, without hint or attempt

Active Publication Date: 2007-10-24
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, the existing technology has not provided scientific basis for the basic issues of whether mono / dicaffeoylquinic acid can be combined with gardenia, whether the mechanism of action of the two is additive, synergistic or antagonistic.
As for whether the two can be used in combination for other diseases (such as cardiovascular and cerebrovascular diseases), the prior art does not even have similar hints or attempts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Embodiment 1 capsule

[0144] Take 5g of gardenia, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml at a time, merge the n-butanol extract, concentrate under reduced pressure to no n-butanol smell, add 200ml of water, heat to dissolve, filter, and the filtrate is spray-dried to obtain Extract I for subsequent use;

[0145] Get one part of extract, get Flos Lonicerae extract (chlorogenic acid content is not less than 50%) 1g, add starch, magnesium stearate, mix, pack in the hard capsule. After testing, each capsule contains 500mg of chlorogenic acid and 100mg of geniposide.

Embodiment 2

[0146] Example 2 tablet

[0147] Take 5 kg of coffee beans, extract with 95% ethanol, dissolve the extract in water and extract with petroleum ether, ethyl acetate and n-butanol respectively to obtain petroleum ether, ethyl acetate and n-butanol. The ethyl acetate part was subjected to silica gel column chromatography and MCI column chromatography to obtain 8 g of dicaffeoyloxyquinic acid and 4 g of quinic acid, respectively. Then 100 mg of dicaffeoyloxy-quinic acid was dissolved in 1000 ml of water to make a 0.1% aqueous solution, heated and dissolved, mixed evenly, sealed in a medicine bottle, sterilized to produce a product, and the extract II was obtained for subsequent use.

[0148] Take two parts of extract I and one part of extract II of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, and granulate according to the standard granulation and tableting process. After testing, it contains dicaffeoylquinic acid...

Embodiment 3

[0149] Embodiment 3 soft capsules

[0150] Get half part of the extract I and five parts of the extract II of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 500mg of dicaffeoylquinic acid and 50mg of geniposide.

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PUM

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Abstract

The invention relates to a medicinal or health product composition, its preparing process and use, wherein the composition contains natural plant extract or active constituents of monomers. The pharmaceutical composition can be used for the treatment and / or prevention of diabetes and cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The present invention relates to a composition for medicinal or functional health products, specifically, a composition containing natural plant extracts or monomers and its application in medicine and functional health products. Background technique [0002] With the rapid development of modern science, people pay more and more attention to "natural" medicines. In recent years, the medical community has done a lot of work in the research of medicinal plants such as treating cardiovascular and cerebrovascular diseases and lowering blood sugar, and has strengthened the analysis and research on biologically active substances in order to further clarify their efficacy. However, the results achieved were limited. This is mainly due to the complex pathogenesis of cardiovascular and cerebrovascular diseases and diabetes, often accompanied by one or more complications of different types, and the existing single natural active ingredient is difficult to be ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A61K36/744A61K36/8945A61P3/10A61P9/00A61P25/28A61P3/06A23L33/00
Inventor 林谷风潘锡平
Owner YUNNAN BIOVALLEY PHARMA CO LTD