Method of preparing traditional Chinese medicine unction formulated product for treating cervical erosion, colpitis

A technology for cervical erosion and vaginitis, applied in the field of pharmaceuticals, can solve problems such as easily polluted clothes, patient discomfort, and affect the curative effect, and achieve the effects of taking it conveniently, ensuring curative effect, and improving bioavailability

Inactive Publication Date: 2008-01-23
修涞贵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Suppositories have the disadvantages of being melted at body temperature and easily lost, affecting curative effect, easily polluting clothes, and causing discomfort to patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Get ginseng stem and leaf saponin 25g, comfrey 500g, Phellodendron 500g, flavescens 500g, dry alum 400g, borneol 200g, catechin 500g, stearic acid 550g, liquid paraffin 250g, white petrolatum 300g, glyceryl monostearate 300g, Tween-80 300g, glycerin 300g;

[0030] Preparation Process:

[0031] (1) Add water to extract catechu and dried alum for 2 times, the first time is 1 hour, the second time is 0.5 hour, the amount of water added is 6 times and 3 times successively, the combined extracts are centrifuged, concentrated under reduced pressure, and spray-dried to obtain Dry extract powder for standby;

[0032] (2) Grind the borneol finely, pass through a 100-mesh sieve, and set aside;

[0033] (3) Boil Cortex Phellodendri, Sophora Sophora, and Comfrey with water for three times. For the first 2 hours, add 9 times the amount of water; Combine three water decoctions, concentrate to a relative density of 1.10-1.15 (80°C), add ethanol to make the alcohol content reach 75%...

Embodiment 2

[0040] Get ginseng stem and leaf saponin 25g, comfrey 500g, cork cork 500g, flavescens 500g, dry alum 400g, borneol 200g, catechin 500g, stearic acid 500g, liquid paraffin 200g, white petrolatum 300g, glyceryl monostearate 210g, Tween-80 350g, glycerin 300g;

[0041] Preparation Process:

[0042] (1) Add water to extract catechu and dried alum for 2 times, the first time is 1.5 hours, the second time is 1 hour, the amount of water added is 7 times and 5 times successively, the combined extracts are centrifuged, concentrated under reduced pressure, and spray-dried to obtain Dry extract powder for standby;

[0043] (2) Grind the borneol finely, pass through a 100-mesh sieve, and set aside;

[0044] (3) Boil Cortex Phellodendri, Sophora Sophora, and Comfrey with water three times, add 10 times the amount of water for the first 2 hours; add 5 times the amount of water and 5 times the amount of water for the second and third times each for 1 hour, Combine three water decoctions,...

Embodiment 3

[0051] Get ginseng stem and leaf saponin 25g, comfrey 500g, Phellodendron 500g, flavescens 500g, dry alum 400g, borneol 200g, catechin 500g, stearic acid 600g, liquid paraffin 200g, white petrolatum 300g, glyceryl monostearate 220g, Tween-80 350g, glycerin 320g;

[0052] Preparation Process:

[0053] (1) Add water to extract catechu and dried alum for 2 times, the first time is 2 hours, the second time is 1 hour, the amount of water added is 8 times and 4 times successively, the combined extracts are centrifuged, concentrated under reduced pressure, and spray-dried to obtain Dry extract powder for standby;

[0054] (2) Grind the borneol finely, pass through a 100-mesh sieve, and set aside;

[0055] (3) Boil Cortex Phellodendri, Sophora Sophora, and Comfrey with water for three times, add 6 times the amount of water for the first 2 hours; add 6 times the amount of water and 5 times the amount of water for the second and third times each for 1 hour, Combine three water decoct...

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PUM

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Abstract

The invention relates to a TCM ointment preparation method for cervical erosion and vaginitis, which belongs to the field of pharmaceutical technology. The preparation process is shown below: catechu and dry alum are extracted by adding water, and the mixed extraction solution are of the centrifugation, decompression, concentrating, spray and drying to get the dry extract powder for stand-by; porphyrizate borneol for stand-by; Boil phellodendron, sophora flavescens ait and lithospermum are decocted for three times by adding water, mix the water decoction to concentrate and alcohol precipitate, keep it static and get the ethanol from the supernatant liquid, and concentrate to get the thick paste for stand-by; screen ginsenosides head of over 80 to 120 for sieving; extract oil phase to melt and stir uniformity with maintained temperature for stand-by; extract water phase to stir uniformity with maintained temperature for stand-by; add oil phase to the water phase while stirring the mixture until the mixture shapes into a uniform and delicate paste; finally pack to get the invention. The medicine prepared by the invention can disperse uniformly in the vaginal cavity and coats wide area so that the medicine can be effectively infiltrates into mucosal folds, thus increasing the bioavailability and ensuring the efficacy. The invention is quite convenient for patients to take without contaminating the clothing.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a preparation method of a traditional Chinese medicine ointment preparation for treating cervical erosion and vaginitis. The international patent classification numbers are A61K35 / 78 and A61P15 / 02. Background technique [0002] The female vaginal mucosa is the squamous epithelial cells covering the surface of the vagina. It is affected by female sex hormones, undergoes periodic changes, and protects the internal tissues. At the same time, these epithelial cells can secrete glycogen, which is decomposed into lactic acid by "Lactobacillus" parasitic in the vagina, so that the vaginal environment maintains an acidic pH of 4-5, and naturally inhibits the growth and reproduction of various harmful pathogens Self-cleaning system , These constitute a natural barrier to maintain women's health. [0003] It has been proved by medicine that any kind of vaginitis is accompanie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P15/02A61P15/00A61K33/06A61K31/045
Inventor 王丽清刘春梅朱丽佳于艳辉姜波王勇
Owner 修涞贵
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