Segmented intestine targeted drug feeding preparation of myocardium protein polypeptide and method of producing the same
A technology of colon-targeted drug delivery and myocardial protein, which is applied in medical formulations, peptide/protein components, medical preparations of non-active ingredients, etc., to achieve the effects of improving medication compliance, good adjuvant therapy, and significant effects
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[0032] The preparation method for preparing the colon-targeted drug delivery preparation of the cardiac muscle protein polypeptide of the present invention comprises the following steps: the first step is to prepare the medicinal powder containing the myocardial protein polypeptide component; the second step is to place the medicinal powder in a centrifugal coating granulator, Spray sucrose syrup to moisten the drug powder, control the spray flow rate, and dry by blowing air to obtain a 60-80-mesh ball core; the third step is to use the ethanol solution of vidpodone K30 as a binder, and use the powder supply machine to spray the ball core Drug powder, control the feed ratio of binder and drug powder, increase the pellet core to 10-3000μm pellets, dry and sieve to obtain the drug-containing pellets; the fourth step, put the drug-containing pellets in a centrifugal bag In the coating granulator, spray the coating solution prepared according to the prescription to the pellets, con...
Embodiment 1
[0035] Take 10 kg of fresh pig heart, add 5 times of 0.9% normal saline, homogenate at high speed, add 20 liters of petroleum ether to degrease three times while stirring, separate the liquid and discard the ether layer, take the degreased solution to adjust to pH 1.5, add appropriate amount of pepsin, Hydrolyze at 37°C for 6 hours, adjust to pH 7.5, add appropriate amount of trypsin, hydrolyze at 37°C for 6 hours, centrifuge at high speed, take supernatant and concentrate by ultrafiltration, collect polypeptide concentrate with molecular weight cut-off less than 10,000 Daltons, add mannitol The excipients were lyophilized to obtain 2.2 kg of off-white polypeptide lyophilized powder.
[0036] Colon-targeted drug delivery preparation of cardiac muscle protein polypeptide and its preparation method: Weigh 20 grams of myocardial protein polypeptide freeze-dried powder, 10 grams of salvia miltiorrhiza extract, mix well, put in a centrifugal coating granulator, spray 50% sucrose syr...
Embodiment 2
[0039] Colon-targeted drug delivery preparation of cardiac muscle protein polypeptide and its preparation method: Weigh 20 grams of myocardial protein polypeptide freeze-dried powder, 10 grams of vitamins, mix well, put it in a centrifugal coating granulator, spray 50% sucrose syrup to moisten the drug powder , 55 ℃ blast drying for 4 hours to prepare 60-80 mesh ball cores, use 3% vidpotone K30 ethanol solution as binder, spray compound drug powder to the ball core by powder supply machine, control the supply of binder and drug powder Ratio of material, so that the core of the pellet is repeatedly increased to a pellet of 100-500 μm, dried and sieved to obtain the pellet containing medicine.
[0040] Weigh 120 grams of acrylic resin (the mixed resin of acrylic resin EUDRAGIT S100 and acrylic resin EUDRAGIT, the mixing ratio of acrylic resin EUDRAGIT S100 and acrylic resin EUDRAGIT is 1:1.5), add it to 1600 ml of 80% ethanol, stir to dissolve, then weigh Add 14 grams of triethy...
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