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Method for catalytic synthesis of dibasic acid ester by using immobilized lipase

A technology for immobilizing lipase and dibasic acid ester, which is applied in the direction of immobilization on/in organic carrier, fermentation, etc., can solve the problems of polluted environment, difficult recovery and reuse, low selectivity of target products, etc.

Inactive Publication Date: 2008-04-09
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the above-mentioned catalyzer that adopts liquid acid has a higher conversion rate (95%-98%) to the reaction, there are following problems: (1) side reactions occur in production, and the target product selectivity is not high; (2) production process Complex, need alkali neutralization, water washing, etc.; (3) The catalyst seriously corrodes the production equipment and pollutes the environment
For example, the method for preparing diisoamyl maleate with heteropolyacid catalysis is to use heteropolyacid to directly mix with reactant to carry out homogeneous esterification reaction, and the esterification rate can reach 95%, but the catalyst is difficult Separated from the system, it is difficult to recycle and reuse, and it also causes product pollution

Method used

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  • Method for catalytic synthesis of dibasic acid ester by using immobilized lipase
  • Method for catalytic synthesis of dibasic acid ester by using immobilized lipase
  • Method for catalytic synthesis of dibasic acid ester by using immobilized lipase

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Preparation and immobilization of embodiment 1 lipase

[0048] The immobilized enzyme refers to the applicant's co-pending Chinese invention patent application No.200510112638.5 and Tan TW, Zhang M, Wang BW, Ying CH, Deng L.Screening of high lipase producing Candida sp.and production oflipase by fermentation.Process Prepared by the method in Biochem 2003; 39(4): 459-65, hereinafter the same.

[0049] The cotton cloth and the co-fixative agent are mixed according to the mass volume ratio of 1:1, and dried at room temperature to obtain the activated carrier. Co-fixative is PEG6000, coconut oil, Tween 80, gelatin, lecithin and magnesium sulfate mixture, and its mass ratio is gelatin: lecithin: PEG6000: Tween 80: magnesium sulfate: coconut oil=5: 1: 1: 2 :1:1. The prepared Yarrow lipolytica lipase aqueous solution is mixed with the activated carrier at a ratio of 8000 U / g activated carrier, soaked, and dried at room temperature to obtain immobilized lipase.

[0050] Unle...

Embodiment 2

[0051] Embodiment 2: the immobilized enzyme prepared in 0.5g embodiment 1 is added in the 10ml n-hexane containing 0.2g sebacic acid and 0.147g (alcohol of 2 times material amount) isobutanol, organic solvent water content is 0.5% , Under the condition of 40°C, the reaction was shaken, and the conversion rate of acid reached 91% in 24 hours.

Embodiment 3

[0052] Embodiment 3: the immobilized enzyme prepared in 0.5g embodiment 1 is added in the 10ml n-hexane containing 0.2g sebacic acid and 0.2576g (alcohol of 2 times material amount) isooctyl alcohol, organic solvent water content is 0.5% , Under the condition of 40°C, the reaction was shaken, and the conversion rate of acid reached 86.04% in 24 hours.

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Abstract

The invention relates to a method for preparing a novel diester, which comprises steps of synthesis using immobilization lipase catalyzed by biprotic fatty acid and monohydric fatty alcohol. The invention also relates to diester preparation and the use thereof as base oil of lubricating oil.

Description

technical field [0001] The invention relates to a method for synthesizing dibasic acid esters. More specifically, the present invention relates to a method for synthesizing dibasic acid ester by using immobilized lipase, especially immobilized microbial lipase, to catalyze the reaction of monobasic fatty alcohol and dibasic fatty acid. The present invention also relates to the dibasic acid ester preparation produced by the method and its use as lubricating oil base oil. Background technique [0002] The base oils of environmentally friendly lubricants are mainly vegetable oils and synthetic esters. Compared with other base oils, synthetic esters have the following lubricating chemical characteristics: (1) Compared with mineral oils, ester oils have a wider liquid range, higher viscosity index, excellent viscosity-temperature performance and low-temperature performance; ( 2) The thermal stability of the ester oil is good; (3) the synthetic ester has a good biodegradation fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/62C12N11/02
Inventor 谭天伟赵娟陈必强
Owner BEIJING UNIV OF CHEM TECH
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