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Scutellaria barbata total flavone and its application in preparing influenza virus resisting medicine

A technology for anti-influenza virus and total flavonoids, which can be used in antiviral agents, pharmaceutical formulations, plant raw materials, etc., and can solve unseen problems

Inactive Publication Date: 2008-04-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Taking a comprehensive view of the reports at home and abroad, there is no anti-influenza virus efficacy of the total flavonoid extract of the dry aerial part of Banzhilian (Scutellaria barbate) and the medicine prepared therefrom.

Method used

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  • Scutellaria barbata total flavone and its application in preparing influenza virus resisting medicine
  • Scutellaria barbata total flavone and its application in preparing influenza virus resisting medicine
  • Scutellaria barbata total flavone and its application in preparing influenza virus resisting medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] 1) Extraction of total flavonoids from Scutellaria barbata:

[0012] Take the Chinese herbal medicine Scutellaria barbata, extract with 50-80% alcohol, concentrate, extract with petroleum ether, put D-101 macroporous resin on the water phase, elute with water and alcohol gradient, collect the eluate, and detect it with magnesium powder / hydrochloric acid , collecting the part with high flavonoid content, concentrating until dry to obtain a solid, that is, the effective part product, the yield of the effective part product is more than 1%, and the total flavonoid content exceeds 50%. Through biological activity testing, the total flavonoids have obvious activity of inhibiting influenza virus.

[0013] The specific extraction and results involve:

[0014] Extraction: crude drug weight 1000 grams

[0015] Extract 131g Yield: 13.1%

[0016] Macroporous resin separation:

[0017] Weight 17.7g Yield 1.77%

[0018] The total flavonoid content is 57.5%, and the total flavon...

Embodiment 2

[0040] Take 50 grams of the obtained total flavonoids extract of Scutellaria barbata, crush it through a 100-mesh sieve, add 3 grams of starch and mix evenly, then add 10% starch slurry in an appropriate amount to make a soft material, granulate with a 20-mesh sieve, 60-70 Dry at ℃, pass through a 30-mesh sieve for granulation, add 3 grams of hydroxypropyl cellulose and 1 gram of magnesium stearate, mix well, press into tablets, and film-coat to obtain 1000 tablets. Each tablet contains 50mg of total flavonoid extract.

Embodiment 3

[0042] Take 50 grams of the obtained total flavonoids extract of Scutellaria barbata, crush it through a 100-mesh sieve, add 3 grams of starch, appropriate amount of microcrystalline fiber, granulate with dilute ethanol, granulate with a 20-mesh sieve, and dry at 60-70°C. Whole grains, add appropriate amount of magnesium stearate, mix well, fill into capsules, 1000 capsules.

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Abstract

The invention relates to total flavone of barbat skullcap and new usage in the preparation of anti-influenza virus drug, belonging to the field of traditional Chinese medicine. The total flavone of barbat skullcap of the invention is total flavone extract which is separated and extracted from the dry aerial part of barbat skullcap which belongs to labiatae scutellaria plant and grows in China. Tested by mass spectrum and 13C, 1H, the total flavone extract of barbat skullcap contains active chemical component 5, 7, 4'-tri-hydroxyl flavone (apigenin) of the above chemical structure. The total flavone extract is tested by in vitro cell model and in vivo animal model and proved to have strong activity of anti-influenza virus. The total flavone extract and active component apigenin can be further prepared into anti-influenza virus drug and the dosage forms can be capsules, tablets, granules, and injection and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to an anti-influenza virus drug, in particular to total flavonoids of Scutellaria barbata and its new application in the preparation of anti-influenza virus drug. Background technique: [0002] Scutellaria barbata is the dried whole herb of Scutellaria barbate in the Lamiaceae family. It is mainly produced in Jiangsu, Jiangxi, Fujian, Guangdong and other places in my country, and its resources are relatively rich. Its main components are flavonoids, diterpenes and diterpene lactones, polysaccharides, and rich trace elements necessary for the human body. Traditional Chinese medicine believes that Banzhilian is pungent, bitter, and cold, and enters the lungs, liver, and kidneys. It can clear away heat and detoxify, remove blood stasis and diuresis. Bruises. Scutellaria barbata has been widely used in traditional Chinese medicine, and there have been in-depth studies on the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K31/352A61K9/16A61K9/20A61K9/48A61P31/16C07D311/30
Inventor 李继扬李幸慰黄海盛德鑫周珮
Owner FUDAN UNIV
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