Method for preparing bioactivity gradient hard tissue alternate material

A replacement material and biologically active technology, applied in metal material coating process, ion implantation plating, coating, etc., to achieve the effects of low degradation speed, long retention time, and low temperature rise

Active Publication Date: 2008-05-28
JIANGSU UNIV
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AI Technical Summary

Problems solved by technology

[0003] Preparation of (FHA+YSZ) bioactive composite gradient hard tissue replacement materials by magnetr...

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0018] Magnetron sputtering method is used to prepare artificial bone implant based on medical metal (Ti, Ti6Al4V, Mg and magnesium alloy) surface (FHA+YSZ) gradient bio-coating, and now the present invention will be further described in conjunction with examples.

[0019] (1) Magnetron sputtering FHA target and (FHA+YSZ) composite target preparation

[0020] Weigh 60 g of FHA nano powder, place it in a blast drying oven to dry, grind and sieve. The FHA target was prepared with a ZRY55 multifunctional vacuum hot-pressing sintering furnace, the hot-pressing pressure was 5t, the hot-pressing temperature was 1150°C, and the hot-pressing atmosphere was N 2 , hold the pressure for 4 hours and then cool with the furnace to obtain a magnetron sputtering FHA target with a specification of 60mm×5mm.

[0021] Add YSZ powder to FHA powder to configure (FHA+YSZ) composite powder, and the mass of YSZ powder accounts for 90%, 80%, 75%, 70%, 60%, and 50% of the total mass of the composite ...

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Abstract

The invention relates to a preparation method of bioactive gradient hard tissue replacement material. Firstly, the pure FHA target material and the FHA plus YSZ compound target materials are prepared by vacuum hot-pressing sintering; the medical metal substrate test sample which is obtained by wire cutting is polished by a metallographical sand paper and then washed, and the substrate after washing is firstly processed by acid etching and then the alkali-heat treatment, so as to obtain the substrate which is processed by activation; the FHA target material, the self-made various groups of compound target materials with different components (FHA plus YSZ) and the medical metal substrate are respectively arranged in a main sputtering chamber and a sample introduction chamber to carry out magnetron sputtering, and post-treatment is carried out in a heat treatment furnace after the completion of magnetron sputtering, then the artificial bone implant which is based on the medical metal surface (FHA plus YSZ) gradient biological coating is obtained. The adhesive strength of the gradient biological coating of the gradient hard tissue replacement material (FHA plus YSZ) which is prepared by the invention and the substrate is high, the temperature increase of the medical metal substrate is low, the components of the coating are even and stable, and the cost is lower; the gradient coating is thinner, the in vivo degradation speed of the FHA gradient coating is lower, the retention time is longer, and the invention is more conductive to the repair and reconstruction of the bone tissues with defects.

Description

technical field [0001] The invention relates to a bioactive composite material bone implant for hard tissue replacement and repair, in particular to a bioactive gradient coating composite material prepared on the basis of magnetron sputtering technology on the surface of medical metal (titanium alloy, magnesium alloy). Background technique [0002] Preparation of hydroxyapatite (HA) bioactive coatings or coated implants on the surface of medical metals Ti, Ti6Al4V, Mg and magnesium alloys, because it combines the good mechanical properties of metals and the good biocompatibility and bioactivity of HA , can be made into hip joints, knee joints, tooth roots and other places with heavy loads and wear-prone parts, and can quickly form a tight biological combination with hard tissues in the living body after being implanted in the living body, without loosening or Deformation has become one of the new hotspots in the field of hard tissue repair and replacement. Compared with pur...

Claims

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Application Information

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IPC IPC(8): A61L27/32C23C14/35
Inventor 赵玉涛林东洋刘晓燕
Owner JIANGSU UNIV
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