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Antidiabetics and antiatheroscloresis medicine compounds and preparing method thereof

A composition and drug technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as poor curative effect, large toxic and side effects, and achieve the effects of regulating blood lipids, promoting insulin secretion, and protecting the liver.

Inactive Publication Date: 2008-07-30
BEIJING SHENZHOU XIANGRUI PHARMA SCI & TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of large toxic and side effects and poor curative effect in the prior art, the present invention provides a kind of hypoglycemic and lipid-lowering pharmaceutical composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The formula that present embodiment adopts is as follows:

[0029] 20-80 parts of berberine hydrochloride, 10-40 parts of rehmannia polysaccharide extract, and 10-60 parts of astragalus polysaccharide extract.

[0030] Preparation:

[0031] Take 20 parts of berberine hydrochloride, 10 parts of rehmannia polysaccharide, 60 parts of astragalus polysaccharide, add appropriate amount of dextrin, and prepare the β-cyclodextrin inclusion compound of Coptis chinensis, Astragalus root, and rehmannia glutinosa extract, add appropriate amount of lactose, microcrystalline cellulose 1. Magnesium trisilicate, using 3% PVP ethanol solution as a binder, made into soft material, passed through 80 mesh sieve to granulate, granulated with 18 mesh sieve when the hot air is blown at about 60 ℃ until it is nearly dry, and granulated with 22 mesh sieve after complete drying Sieve out the fine powder to obtain uniform granules, and then coat them to obtain granules.

[0032] Prepared dosage...

Embodiment 2

[0091] The formula that present embodiment adopts is as follows:

[0092] 20-80 parts of berberine hydrochloride, 10-40 parts of rehmannia polysaccharide extract, and 10-60 parts of astragalus polysaccharide extract.

[0093] Preparation method: Take 20 parts of berberine hydrochloride, 40 parts of rehmannia polysaccharide, 10 parts of astragalus polysaccharide, add appropriate amount of dextrin, and prepare β-cyclodextrin inclusion compound of Coptis chinensis, Astragalus root, and rehmannia root extract, add appropriate amount of lactose, micro Crystal cellulose, magnesium trisilicate, 3% PVP ethanol solution as binder, made into soft materials, granulated through 80 mesh sieve, granulated with 18 mesh sieve when the hot air blows at about 60 ℃ until it is nearly dry, and used after complete drying Sieve out the fine powder with a 22-mesh sieve to obtain uniform granules, and then coat them to obtain granules.

[0094] Preparation of dosage forms: preparation of granules

...

Embodiment 3

[0152] The formula that present embodiment adopts is as follows:

[0153] 20-80 parts of berberine hydrochloride, 10-40 parts of rehmannia polysaccharide extract, and 10-60 parts of astragalus polysaccharide extract.

[0154] Preparation method: take 80 parts of berberine hydrochloride, 10 parts of rehmannia polysaccharide extract, 10 parts of astragalus polysaccharide extract, appropriate amount of dressing, take 100g of β-CD and add 200ml of distilled water, grind it evenly, and then grind it with Sg of Sanhuang extract evenly. Drying at lower temperature can obtain β-cyclodextrin inclusion compound, then add certain auxiliary materials, granulate, compress into tablets, and film-coat.

[0155] Dosage Form: Made into Tablets

[0156] Animal experiment

[0157] 2. Experimental materials

[0158] 1.1 Experimental reagents and equipment:

[0159] Coptidis, Radix Astragali, and Dihuang medicinal decoction pieces were purchased from Beijing Jingwei Pharmacy, and metformin hyd...

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PUM

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Abstract

The invention relates to a medical composition for sugar and lipid-decreasing and the preparation method thereof. The effective drug effect composition of the medical composition for sugar and lipid-decreasing provided by the invention is formed by the raw materials with the following weight account: berberine hydrochloride of 20 to 80 portions, radix rehmanniae polysaccharide extract of 10 to 40 portions, and astragalus polysaccharide extract of 10 to 60 portions. The invention also provides the preparation of the medical composition for sugar and lipid-decreasing and the medicine used for treating hyperglycemia, hyperlipidemia and relative diseases prepared by the medical composition for sugar and lipid-decreasing. The animal experiments show that: the medical composition provided by the invention with an obvious blood sugar-decreasing efficacy has the advantages of protecting islet cells, promoting the insulin secretion, adjusting blood lipid, and protecting the liver.

Description

technical field [0001] The invention relates to a hypoglycemic and lipid-lowering pharmaceutical composition and a preparation method thereof. Background technique [0002] Diabetes mellitus (DM) is a common endocrine and metabolic disorder caused by relative or absolute insufficiency of insulin secretion in the body, decreased sensitivity of target cells to insulin, or structural defects in insulin itself. Diabetes persists for life, and its complications seriously threaten human health. At present, my country's diabetic patients have reached 50 million, and with the improvement of people's living standards, the number of patients is still increasing. Hyperlipidemia is one of the important risk factors of arteriosclerosis and coronary heart disease, and is the pathological basis of cardiovascular and cerebrovascular diseases. Diabetes, cancer, and cardiovascular disease are known as the world's three major diseases. [0003] Among the western medicines currently used for ...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K31/715A61P3/06A61P3/10A61K31/4375
Inventor 胡文祥徐楠楠王卓金瑾张卓勇
Owner BEIJING SHENZHOU XIANGRUI PHARMA SCI & TECH DEV
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