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Chinese medicine extract and medicine use thereof

A technology of extracts and apigenin, which is applied in the directions of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2008-08-27
胡军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparations of Shanxiang round leaves on the market include Shanxiangyuan granules, Shanxiangyuan tablets, and Shanxiangyuan buccal tablets. Good curative effect, so far there have been no reports of adverse reactions of the leaves and its preparations

Method used

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  • Chinese medicine extract and medicine use thereof
  • Chinese medicine extract and medicine use thereof
  • Chinese medicine extract and medicine use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Take the leaves of Shanxiangyuan, add water and decoct 2 times, the first time is 30 times the amount for 2 hours, and the second time is 25 times the amount for 1.5 hours. Combine the decoction and concentrate under reduced pressure to a relative density of 1.08~1.18 (80 ℃ heat test) the clear paste, add ethanol to 75% alcohol content, stir, let stand for 24 hours, filter, the filtrate recovers the ethanol, concentrated under reduced pressure to 1:0.8 ~ 1.6 (W / V), diluted with water 3 times the amount of medicinal materials (V / W), adjust the pH to 4 by dilute hydrochloric acid, slowly pass (about 1BV / hr) 2 times the amount of medicinal materials (W / W) processed AB-8 macroporous adsorption resin column , Water eluted 3BV (about 2BV / hr), 15% ethanol eluted 3BV (about 2BV / hr), 65% ethanol eluted, collected 65% ethanol eluate, recovered ethanol, concentrated under reduced pressure, spray-dried to obtain The extract from the leaves of Serratia vulgaris, the yield is ...

Embodiment 2

[0058] Example 2: Same as Example 1 by boiling and alcohol precipitation process to obtain the extract, slowly passing (about 1BV / hr) 2 times the amount of medicinal material (W / W) processed polyamide column, water elution 4BV( Approximately 2BV / hr), eluted with 95% ethanol, collected the eluate, recovered the ethanol, concentrated under reduced pressure, and spray-dried to obtain the sagebrush leaf extract with a yield of about 3.4%.

Embodiment 3

[0059] Example 3: Same as Example 1 by boiling and alcohol precipitation process to obtain the extract, adjust the pH to 4 with dilute hydrochloric acid, extract 4 times with water-saturated n-butanol, combine the extracts, recover the n-butanol under reduced pressure, concentrate, and spray Dry it and get it; or mix the n-butanol extraction concentrate with an appropriate amount of diatomaceous earth, dry it, add ethanol to extract twice, combine the ethanol extracts, recover the ethanol, concentrate under reduced pressure, and spray dry to get it. The yield is about It is 2.6~3.6%.

[0060] 1. Determination of total phenolic acid content:

[0061] According to ultraviolet-visible spectrophotometry (Chinese Pharmacopoeia 2005 edition one appendix V A) determination.

[0062] Preparation of the reference substance solution Accurately weigh the gallic acid reference substance, add absolute ethanol to make a solution containing 20μg per 1ml, and set aside.

[0063] Preparation of th...

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Abstract

The invention belongs to the traditional Chinese medicinal material field, and relates to a Turpinia arguta leaf extract, which contains a flavonoid chemical constituent and acceptable salt in the medicine thereof. The content of total flavonoids is more than 15 percent; the content of apigenin aglycon and a flavone glycoside constituent which uses apigenin as aglycon is no less than 1.5 percent measured in the apigenin; a flavonoid chemical constituent contains one or more of the apigenin, apigenin-7-O-Bata-neohesperidoside, apigenin-7-O-2<1>-Bata-rhamanopyranosyl rutinoside, apigenin-7-O-Bata-glucoside, luteolin-7-O-Bata-glucoside. The invention furhter provides a method for preparing the extract thereof, a method for controlling the quality of the extract, and the application of the extract for preparing the medicines such as antibiosis, oxidation resistance, anti-mutation, antitumor, hepatic protection, anti-hepatitis b virus, anti-thrombosis, anti-arteriosclerosis, etc.

Description

Technical field [0001] The present invention relates to a traditional Chinese medicine extract, in particular to a mountain squash leaf extract containing apigenin and / or flavonoid glycosides with apigenin as aglycon and a medically acceptable salt thereof and the composition of the extract The preparation method, the quality control method of the extract, and the preparation of the extract in antibacterial, antiviral, antioxidant, anti-mutation, anti-tumor, anti-thrombosis, anti-arteriosclerosis, liver protection, anti-hepatitis B virus, anti-depression, neuron protection And immunomodulatory drugs, such as in the preparation of drugs for the treatment of pharyngitis, oral ulcers, gynecological inflammation, hepatitis, viral colds, tumors and cardiovascular and cerebrovascular diseases. Background technique [0002] Shanxiangyuan leaves are fresh or dried leaves of Turpinia arguta Seem., an oily plant in the province. It has the effects of clearing heat and relieving fire, relie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K31/7048A61P1/16A61P7/02A61P9/10A61P25/00A61P25/24A61P31/04A61P31/12A61P31/20A61P35/00A61P37/02A61P39/06A61K127/00
Inventor 胡军
Owner 胡军
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