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Diphenyl ethylene glycosides derivatives

A technology of ethanol and compounds, applied in the field of medicine, can solve the problems of unreachable industrial production, cumbersome process, high cost, etc., and achieve the effect of improving the effect of large dosage, accurate drug effect and less impurities

Inactive Publication Date: 2011-05-04
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, Chinese patent ZL98120290.X discloses a method for preparing stilbene glycosides. This method performs destructive cutting on the chromatographic column used for separation and purification, and then performs sampling and separation. The process is cumbersome and the cost is extremely high, which is also a typical The method of preparing micro samples in the laboratory cannot meet the requirements of industrial production

Method used

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  • Diphenyl ethylene glycosides derivatives
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  • Diphenyl ethylene glycosides derivatives

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Take the above crude product, add acetone: water: ethyl acetate (2:10:1, V / V / V) 9L, heat to dissolve at 60°C, add an appropriate amount of activated carbon, heat and reflux for 15 minutes, filter while hot, and place the filtrate in- Stand at 5°C for 15 hours, after crystallization is sufficient, filter and dry to obtain 1.28 kg of white stilbene glycoside crystals. The above samples were taken, and the content was determined by high performance liquid chromatography. The content of the crude stilbene glycoside was 90.3%, and the content of the stilbene glycoside crystal was 98.9%.

[0052] Example 2

[0053] Take 100kg of dried Radix Polygoni Multiflori, crush it into a coarse powder, put it into a heat reflux extraction tank, add 8 times the amount of water and an appropriate amount of sodium bisulfite, adjust the pH of the extract to 7.5, heat and reflux extraction twice, each time for 2 hours, Combine the extracts, filter, and collect the filtrate. Pass the filtra...

Embodiment 2

[0055] Take the above crude product, add water: ethyl acetate (20:1, V / V) 8L, heat at 60°C until dissolved, add an appropriate amount of activated carbon, heat to reflux for 5 minutes, filter while hot, and place the filtrate at -10°C After 10 hours, after sufficient crystallization, filter and dry to obtain 1.28 kg of white stilbene glycoside crystals, which are needle-shaped and aggregated into clusters. The above samples were taken, and the content was determined by high performance liquid chromatography. The content of the crude stilbene glycoside was 91.1%, and the content of the stilbene glycoside crystal was 99.6%.

[0056] Example 3

[0057] Take 120kg of dried Polygonum multiflorum, crush it into coarse powder, put it into a hot reflux extraction tank, add 7 times the amount of water and an appropriate amount of sodium carbonate, adjust the pH of the extract to 7.8, heat and reflux for 3 times, each time for 1.5 hours, and combine the extractions liquid, filtered, an...

Embodiment 3

[0059] Take the above crude product, add acetone: water: ethyl acetate (1:10:1, V / V / V) 10L, heat to dissolve at 50°C, add an appropriate amount of activated carbon, heat and reflux for 10 minutes, filter while hot, and place the filtrate in- Stand at 4°C for 20 hours, after crystallization is sufficient, filter and dry to obtain 1.51 kg of white stilbene glycoside crystals, which are needle-shaped and aggregated into clusters. The above sample was taken, and the content was determined by high performance liquid chromatography. The content of the crude stilbene glycoside was 92.8%, and the content of the stilbene glycoside crystal was 99.9%.

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Abstract

The invention relates to a new type 2, 3, 5, 4'- tetra-hydroxyl diphenyl ethylene-2-O-beta-D-glucoside crystal, a method for making same, and pharmaceutical compositions containing the crystal. The content of the crystal is 90-99. 9tested by high performance liquid chromatography, and the stilbene glucoside crystal of high-purity is obtained by abstracting fleece-flower root, extracting with an organic solvent, separating by column chromatography and crystallizing in appropriate dissolvent. The preparing process provides high yield, low cost, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a separation and purification process of effective monomer 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in Radix Polygoni Multiflori; also relates to 2,3,5 , Crystal of 4'-tetrahydroxystilbene-2-O-β-D-glucoside, preparation method thereof, and pharmaceutical composition containing it as main component. Background technique [0002] Polygonum multiflorum is the tuber root of Polygonum multiflorum Thunb., which is a commonly used traditional Chinese medicine with a long history of medicinal use. A large number of research results at home and abroad show that Polygonum multiflorum has many functions such as immune regulation, liver protection, anti-oxidation, anti-tumor, and blood fat reduction. pharmacological activity. With the deepening of research, the research on its chemical composition has become more and more clear. A large number of studies have shown that the main role ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/203A61K31/7034A61K36/704A61P39/06A61K125/00
Inventor 杨永安王鸯
Owner NANJING CHIA TAI TIANQING PHARMA
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