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Phospholipid modified poly (ether-sulfone) ultrafiltration membrane capable of resisting protein pollution and preparation

A polyethersulfone ultrafiltration membrane and protein technology, which is applied in the field of phospholipid modified polyethersulfone ultrafiltration membrane and its preparation, can solve the problems of decreased flux, complex operation, harsh conditions, etc., and achieve the improvement of anti-pollution ability and the preparation process Simple, Hydrophilic Enhanced Effects

Inactive Publication Date: 2008-09-10
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyethersulfone is highly hydrophobic, which can easily cause adsorption or deposition of proteins on the surface of the membrane, resulting in serious membrane fouling, resulting in decreased flux and reduced separation efficiency.
In the literature, a variety of methods (chemical treatment modification method, low temperature plasma modification method, etc.) have been applied to the membrane surface modification to enhance the anti-fouling performance of the membrane surface, but most modification methods are complicated to operate and have harsh conditions

Method used

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  • Phospholipid modified poly (ether-sulfone) ultrafiltration membrane capable of resisting protein pollution and preparation
  • Phospholipid modified poly (ether-sulfone) ultrafiltration membrane capable of resisting protein pollution and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 2-phosphatidylcholine hydroxyethyl acrylate (MPC) and n-butyl methacrylate (BMA) in a molar ratio of 3:7 in ethanol, pour into a four-neck flask equipped with a stirrer and a condenser, After introducing nitrogen gas to exhaust the oxygen in the device, add the initiator - azobisisobutyronitrile (AIBN), and stir at 60°C for 20 hours. After 20 hours, the liquid was cooled to room temperature and poured into water to obtain a precipitate, which was washed repeatedly, and the obtained phospholipid copolymer (MPC-BMA) was vacuum-dried for future use. The monomer concentration and AIBN concentration were 0.5 mol / l and 5.0 mmol / l, respectively. Weigh 5.00g of polyethersulfone, 4.17g of polyethylene glycol, 0.32g of phospholipid copolymer (MPC-BMA) and 18.55g of N,N-dimethylformamide into a three-necked flask, and put it in a constant temperature water bath at 60°C Heating at medium temperature, stirring for 4 hours, after mixing evenly, stand at 60°C for 2-4 hours f...

Embodiment 2

[0020] Dissolve 2-phosphatidylcholine hydroxyethyl acrylate (MPC) and n-butyl methacrylate (BMA) in a molar ratio of 3:7 in ethanol, pour into a four-necked flask equipped with a stirrer and a condenser, After introducing nitrogen gas to exhaust the oxygen in the device, add the initiator - azobisisobutyronitrile (AIBN), and stir at 60°C for 20 hours. After 20 hours, the liquid was cooled to room temperature and poured into water to obtain a precipitate, which was washed repeatedly, and the obtained phospholipid copolymer (MPC-BMA) was vacuum-dried for future use. The monomer concentration and AIBN concentration were 0.5 mol / l and 5.0 mmol / l, respectively. Weigh 5.12g of polyethersulfone, 4.27g of polyethylene glycol, 0.64g of phospholipid copolymer (MPC-BMA) and 18.91g of N,N-dimethylformamide into a three-necked flask, and put it in a constant temperature water bath at 60°C Heating at medium temperature, stirring for 4 hours, after mixing evenly, stand at 60°C for 2-4 hours...

Embodiment 3

[0023] Dissolve 2-phosphatidylcholine hydroxyethyl acrylate (MPC) and n-butyl methacrylate (BMA) in a molar ratio of 3:7 in ethanol, pour into a four-necked flask equipped with a stirrer and a condenser, After introducing nitrogen gas to exhaust the oxygen in the device, add the initiator - azobisisobutyronitrile (AIBN), and stir at 60°C for 20 hours. After 20 hours, the liquid was cooled to room temperature and poured into water to obtain a precipitate, which was washed repeatedly, and the obtained phospholipid copolymer (MPC-BMA) was vacuum-dried for future use. The monomer concentration and AIBN concentration were 0.5 mol / l and 5.0 mmol / l, respectively. Weigh 5.31g of polyethersulfone, 4.42g of polyethylene glycol, 0.96g of phospholipid copolymer (MPC-BMA) and 19.47g of N,N-dimethylformamide into a three-necked flask, and put it in a constant temperature water bath at 60°C Heating at medium temperature, stirring for 4 hours, after mixing evenly, stand at 60°C for 2-4 hours...

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Abstract

The invention relates to a phospholipid modification polyether sulfone ultrafiltration membrane which resists protein pollution and a preparation method thereof. The invention takes phospholipid copolymer (MPC-BMA), the polyether sulfone (PES) and polyethyleneglycol (PEG2000) as the raw materials and prepares the materials according to the mass fraction of 0 to 4.8 percent of the phospholipid copolymer, 18 percent of the polyether sulfone and 15 percent of the polyethyleneglycol (PEG2000). The preparation method includes: the polyethyleneglycol and the phospholipid copolymer (MPC-BMA) are added in the N, N-dimethylformamide of the polyether sulfone (PES); the mixture is stirred for 4 to 6 hours under a temperature of 50 to 60 DEG C; the prepared uniform-phase casting solution stands for being defoamed for 2 to 4 hours under a temperature of 50 to 60 DEG C, is poured on a glass plate for membrane scraping after being cooled, and then is put into a water bath for being concreted and shaped into membrane after standing; the membrane is dipped in water for 24 to 36 hours to obtain the phospholipid modification polyether sulfone ultrafiltration membrane. The invention has simple process and gentle conditions; the obtained modification ultrafiltration membrane has excellent anti-pollution performance and can be applied to the separation of biological products, etc.

Description

technical field [0001] The invention relates to an ultrafiltration membrane preparation technology, in particular to a protein-polluted phospholipid-modified polyethersulfone ultrafiltration membrane and a preparation method. Background technique [0002] Ultrafiltration is a liquid phase sieve separation process under the driving force of static pressure difference. The difference in molecular weight of the separated substances is used to separate them, the small molecular substances pass through the membrane, and the large molecular substances are intercepted to achieve the purpose of purification, separation and concentration. Ultrafiltration technology is mainly used in the separation of macromolecular compounds (proteins, nucleic acid polymers, enzymes, etc.), colloidal dispersions (clay, pigments, mineral materials, etc.), emulsions (grease, detergent, oil-water emulsion, etc.) ). Compared with traditional separation processes such as rectification, adsorption, and e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68
Inventor 苏延磊姜忠义李超赵为
Owner TIANJIN UNIV