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Oral preparation containing cefa-iskia, preparation method and application thereof

A cephalexin and preparation technology, applied in the field of therapeutic drugs and preparation thereof, can solve the problems of low blood drug concentration, slow absorption, long time to reach effective blood drug concentration, etc., and achieves simple production process, fast onset of action, and improved dissolution rate. degree of effect

Inactive Publication Date: 2008-09-24
北京亿利高科生物工程技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the slow oral absorption of tablets, etc., the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentration of the drug in the lesion is lower, and the time to reach the effective blood drug concentration in the lesion is also longer. Affect its effective antibacterial potency

Method used

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  • Oral preparation containing cefa-iskia, preparation method and application thereof
  • Oral preparation containing cefa-iskia, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 - Cephalexin Candy

[0044] Prescription: cephalexin 125g, sucrose 818.5g, citric acid 10g, food coloring-400.1g, mannitol 10g, hypromellose 36.5g, preparation amount 1000 tablets.

[0045] Method: Prepare a mixture of cephalexin 125g, citric acid 10g, food coloring-400.1g, mannitol 10g, and hypromellose 36.5g, grind it, and pass it through a 20-mesh sieve. Take 818.5 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, place on a product forming machine and extrude, each lozenge weighs 2 grams. Then measure the disintegration time limit of cephalexin candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0046] Results: The disintegration time limit was 28-35 minutes, and the dissolution rate was 84%-89% when completely disintegrated.

Embodiment 2

[0047] Example 2-low sugar cephalexin candy

[0048] Prescription: cephalexin 125g, sucrose 168.5g, fructooligosaccharide 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-400.1g, mannitol 10g, hypromellose 36.5g, dosage 1000 tablets .

[0049] Method: Prepare a mixture of citric acid 10g, food coloring-400.1g, mannitol 10g, and hypromellose 36.5g, grind it, and pass it through a 20-mesh sieve. Take 168.5g of sucrose, 300g of fructooligosaccharides, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, add the sieved mixture, stir rapidly for 10 minutes, cool to 85°C, add 125g of cephalexin, and quickly Stir for 10 minutes, place on a product forming machine and extrude, each lozenge weighs 2 grams. Then measure the disintegration time limit of cephalexin candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0050] Results: The disintegration time limit was 28-36 minutes, and the dissolution rate was 85%-91% when co...

Embodiment 3

[0051] Embodiment 3-cephalexin buccal tablet

[0052] Prescription: cephalexin 125 grams, hypromellose 128 grams, polyethylene glycol 6000 746 grams, 1 gram of aspartame.

[0053] Method: Prepare 128 grams of hypromellose, polyethylene glycol 6000 746 grams, 1 gram of aspartame mixed matrix, heating and melting, cooling to 80 ° C, adding 125 grams of cephalexin, stirring and mixing, cooling at room temperature until solidified, granulating, and extruding on a tablet machine. Tablets weigh 1 gram. Then measure the disintegration time limit of cephalexin buccal tablet in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0054] Results: The disintegration time limit was 24-31 minutes, and the dissolution rate was 85%-92% when completely disintegrated.

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Abstract

The invention relates to a buccal preparation containing cefalexin as well as a preparation method and usage thereof. The invention aims at providing a buccal preparation taking cefalexin as ingredient, which is dissolved in saliva of oral cavity by sucking to enter the periphery of the oral cavity, the pharyngeal portion and the pharyngeal tonsils part, so as to play the role of antibacterium. The buccal preparation takes the cefalexin and ramification thereof as the raw material, and can be made into preparations such as buccal tablet, candy and pill, etc. The buccal preparation has the characteristics of rapid effect, good healing efficacy and convenient administration, etc., and can directly increase the concentration of bacteriophage drug at the parts of pathological changes, enhances the antibacterial capacity and is more suitable for the patients.

Description

technical field [0001] The invention relates to a therapeutic drug and its preparation method and application, in particular to an oral preparation containing cephalexin and its preparation method and application. Background technique [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/545A61P31/04A61P1/02A61P11/04
Inventor 刘凤鸣
Owner 北京亿利高科生物工程技术研究所有限公司
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