Coptis chinensis total alkaloid extracting technique

Abstract

The invention relates to the extraction technology of a rhizoma coptidis total alkaloid and the process flow is as follows: raw materials (rhizoma coptidis or coptis fibrous roots or coptis leaves), pulverization (Coptis fibrous roots or coptis leaves need no pulverizing.), addition of right amount of sulphuric acid of 0.01 to 10 percent for soaking, heated extraction for four times, preconcentration, sediment of sodium chloride and high-valencied metal salt, filtration, drying and products of rhizoma coptidis total alkaloid. The main active ingredients for the product are berberine, coptisine, jateorrhizine, palmatine, epiberberine and other active coptis ingredients, the content of rhizoma coptidis total alkaloid is over 20 percent, wherein, the content of berberine is over 10 percent. The product adopts coptis fibrous roots and so on as raw materials to extract rhizoma coptidis total alkaloid, which is different from the traditional extraction of berberine. The extraction technology improves the pure quotient of the product and particularly eliminates cold-natured ingredients of toxic and side effect through the operating procedure of impurity eliminating, thereby improving theproduct quality. Besides the traditionally-utilized berberine, the product still contains a large quantity of other active coptis ingredients such as coptisine, jateorrhizine, palmatine, epiberberineand so on. The product has a higher utilization rate of resources and a higher security of products, and the effective function and action of rhizoma coptidis can be brought into a better play.

Description

technical field [0001] The invention belongs to biological extraction technology, in particular to a process for extracting total alkaloids from Coptis chinensis. Background technique [0002] Coptis chinensis is bitter in taste, cold in nature, and has the functions of purging fire, detoxifying, clearing away heat, and drying dampness. For dysphoria, confusion, upset and insomnia, hot and humid fullness, vomiting, abdominal pain and diarrhea, conjunctival congestion and swelling, sore tongue, eczema, burns, vomiting blood, epistaxis, etc. Modern pharmacology and clinical research results show that berberine has hypolipidemic and hypoglycemic activity. Coptis chinensis was first recorded in "Shen Nong's Materia Medica" and listed as top grade. All kinds of coptis mainly contain berberine (Berberine, also known as berberine), and others still contain coptisine (Coptise), methyl coptisine (Worenine), palmatine (Palmatine), jatrorrhizine (Jatrorrhizine) and epitope Alkaloids...

AI Technical Summary

Problems solved by technology

According to our research experience, the extraction rate of total alkaloids such as berberine is poor when Coptis Rhizoma is directly decocted with water; after Coptis Rhizoma alkaloids are applied to resin, the resin is difficult to regenerate 100% during elution, and the resin utilization rate is not high; when recovering ethanol, The unavoidable loss of ethanol and high energy consumption have caused the cost to rise; at the same time, using Coptis chinensis as raw material, because Coptis chinensis is a famous and precious traditional Chinese medicine, the cost is relatively high.

[0005] To sum up, although there are many and mature techniques for extracting berberine, the raw materials for extraction are mainly three needles or Cortex Phellodendri; there are very few cases where berberine is used as a raw material (only see 1 item), especially The technology of extracting the total alkaloids of Coptis chinensis by taking the by-products such as Coptis chinensis as raw materials has not been reported yet.