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Application of clock wise D-methionine in preparing the medicine for preventing and curing the myelosuppression induced by radiation

A technology of D-methionine and bone marrow suppression, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., which can solve the problems of uncertain curative effect and high cost of use

Inactive Publication Date: 2008-10-15
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of drugs, most of which are used in combination. The curative effect is not very certain when evaluated separately, and there will be various side effects, such as growth factors, and the cost of use is relatively expensive.

Method used

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  • Application of clock wise D-methionine in preparing the medicine for preventing and curing the myelosuppression induced by radiation
  • Application of clock wise D-methionine in preparing the medicine for preventing and curing the myelosuppression induced by radiation
  • Application of clock wise D-methionine in preparing the medicine for preventing and curing the myelosuppression induced by radiation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] D-met100mg, lactose 50mg, microcrystalline cellulose 80mg, starch 50mg, hydroxymethylcellulose 40mg, magnesium stearate 5mg. Pass the active ingredients, lactose, starch, and microcrystalline cellulose through a 100-mesh sieve, and mix thoroughly, add 2% carboxymethylcellulose aqueous solution to the above mixed powder and mix, pass through a 20-mesh sieve to make soft materials, and obtain wet granules Dry at 45-55°C, add sodium carboxymethyl starch and magnesium stearate to the above-mentioned dry granules and press into tablets.

Embodiment 2

[0082] D-met 100mg, Shengbaixin 500mg, add 4g (lactose-microcrystalline fiber 5:1), magnesium stearate 1%, granulate with 70% ethanol, and compress into tablets.

Embodiment 3

[0084] D-met 10g, mannitol 60g, add 1000ml water for injection to dissolve, add water for injection to 2000ml, add appropriate amount of activated carbon to remove heat source, filter with 0.2um microporous membrane, fill, freeze-dry, and prepare 2000 freeze-dried powder injections . Specifications: 70mg / bottle, for intravenous injection.

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Abstract

The invention discloses an application of D-methionine in preparing drugs for preventing or treating bone marrow suppression induced by radiation and chemical toxicants. The modern pharmacological experiment shows that after being injected with 300-1,000 mg / Kg D-methionine, a mouse obtains obvious protective effect on bone marrow suppression induced by radiation and chemical toxicants, indicating that preventive administration can prevent and treat bone marrow damage induced by the radiation and the chemical toxicants and has inhibitory effect on tumor cell growth. The D-methionine can be mixed with conventional pharmaceutically-acceptable adjuvant and made into various dosage forms. For radiotherapy patients, the addition of a certain amount of D-methionine into nutrient solution brings effects of inhibiting tumor cell growth and protecting hematopoietic cells.

Description

technical field [0001] The invention relates to the application of amino acid drugs in the field of pharmacy. More specifically, it is an application of D-methionine (D-met) in the preparation of drugs for preventing and treating bone marrow suppression induced by radiation and chemical poisons. Background technique [0002] The body is exposed to various harmful factors produced by external physical chemistry and internal metabolism, such as exposure to radiation or certain chemical poisons, and patients receiving clinical radiotherapy and chemotherapy. The hematopoietic system is composed of a small amount of bone marrow hematopoietic stem cells and different series of hematopoietic cells at different developmental stages. It is very sensitive to various harmful factors, and will be inhibited to varying degrees after being injured, manifested as decreased peripheral blood leukocytes, decreased bone marrow proliferation function, and even regeneration. Obstructive anemia s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P43/00
Inventor 孟爱民李德冠王月英吴红英王勇褚丽萍张俊伶路璐常建辉
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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