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Medicament composition containing protoberberine type alkaloids

A technology of proberberine and alkaloids, applied in the field of medicine, to achieve the effects of clear mechanism of action, good stability and uniformity of preparations, and reduction of ineffective ingredients

Active Publication Date: 2008-12-24
XIAN XINTONG PHARM RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After searching, there is no relevant report on the application of the combination of proberberine and phenolic acids or aldehydes to cardiovascular and cerebrovascular diseases. Drugs for cardiovascular and cerebrovascular diseases are quite necessary

Method used

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  • Medicament composition containing protoberberine type alkaloids
  • Medicament composition containing protoberberine type alkaloids
  • Medicament composition containing protoberberine type alkaloids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of Compound Huanggui Tablets (Berberine and Cinnamaldehyde)

[0025] 1.1 Prescription Berberine Hydrochloride 100g

[0026] Cinnamaldehyde 10g

[0027] β-cyclodextrin 80g

[0028] Lactose 80g

[0029] Microcrystalline Cellulose 40g

[0030] Crosslinked PVP 25g

[0031] 3% PVPK30 ethanol solution 50ml

[0032] Magnesium Stearate 3g

[0033]

[0034] Makes 1000 pieces

[0035] 1.2 Preparation method

[0036] Weigh the prescribed amount of β-cyclodextrin and add 200ml of distilled water and mix evenly, heat until completely dissolved, place at room temperature, add cinnamon aldehyde to mix, shake fully, stir for 3 hours, put in the refrigerator (2-5°C) overnight, Suction. The clathrate was washed with a small amount of distilled water and dried; then washed with a small amount of ether and dried. Dry under vacuum and reduced pressure at ...

Embodiment 2

[0038] Embodiment two: Compound Huangwei Tablets (berberine+ferulic acid)

[0039] 2.1 Prescription:

[0040] Berberine Hydrochloride 100g

[0041] Ferulic acid 6.25g

[0042] Lactose 80g

[0043] Microcrystalline Cellulose 40g

[0044] Crosslinked PVP 25g

[0045] 3% PVPK30 alcohol solution 45ml

[0046] Micronized silica gel 4g

[0047]

[0048] Makes 1000 pieces

[0049] 2.2 Preparation method:

[0050] Pass the berberine and ferulic acid in the prescription through a 100-mesh sieve respectively, mix well, and set aside; pass the lactose, microcrystalline cellulose, and cross-linked PVP in the prescription respectively through a 100-mesh sieve, mix well, and then mix them with berberine and Mix the mixture of ferulic acid evenly, make soft material with 3% PVPK30 alcohol solution, granulate with 20 mesh sieve, blow dry at 60°C for 2 hours, granulate with 18 me...

Embodiment 3

[0051] Embodiment three: compound xanthan injection (berberine and protocatechualdehyde)

[0052] 3.1 Prescription

[0053] Berberine Hydrochloride 25g

[0054] (98.5% based on berberine ([C20H18NO4]+)

[0055] Protocatechualdehyde 10g

[0056] Sodium sulfite 2g

[0057] EDTA-2Na 1g

[0058] Add water for injection to 2000ml

[0059]

[0060] Made 1000 pieces

[0061] 3.2 Production method:

[0062] Add the prescribed amount of berberine into 1600ml of water for injection, heat and stir until completely dissolved, then add the prescribed amount of sodium sulfite and EDTA-2Na and stir to dissolve, add the prescribed amount of protocatechualdehyde, stir until dissolved, and adjust the pH with dilute hydrochloric acid The value is 7.82 (7.5-8.0), add activated carbon, stir at 70-80°C for 20 minutes, decarburize by fine filtration, and make up to the full amount with water for i...

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Abstract

The invention relates to a medicinal composite containing berberine-type alkaloid. The medicinal composite contains berberine-type alkaloid and a phenol-acid or aldehydes composite or berberine-type alkaloid and a phenol-acid or aldehydes derivative composite, as well as pharmacologically acceptable accessory agent. The invention provides a medicinal composite which has an obvious function of synergistic reaction in the aspect of preventing and curing cardiovascular and cerebrovascular diseases, wherein, the production cost and the product quality of the medicinal composite are easier to be controlled, the stability and the uniformality of the preparation are good, the product quality is controllable, the bioavailability is high, and the medicinal composite contains berberine-type alkaloid.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a pharmaceutical composition containing proberberine-type alkaloids. Background technique [0002] Protoberberine-type alkaloids are derived from benzyl tetrahydroisoquinoline, and the representative types are: protoberberine, also known as berberine, Tetrahydrocoptisine, methyl Coptisine (worenine), jatrorrhizine (jatrorrhizine), palmatine (palmatine), magnoflorine, etc. Proberberine-type alkaloids have antibacterial, analgesic and hypoglycemic effects, which are commonly used clinical pharmacological effects. Such as: the use of original berberine alkaloids in the preparation of anti-drug-resistant bacteria drugs (see application number 200710066144.7), the in vitro bactericidal activity of original berberine derivatives on skin filamentous fungi (see application number is 98813989.8). Someone discovered the application of proberberine in the treatment of relapse drugs for...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/192A61K31/11A61P9/00A61P9/06
Inventor 张登科
Owner XIAN XINTONG PHARM RES CO LTD
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