Preparation method for pH controlled releasedynamic polymer packaging system
A controlled release and polymer technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of abnormal rapidity, uncontrollable release, and difficulty in dissociation, etc. problems, to achieve the effect of broad application prospects
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[0032] Example 1
[0033] Step 1: Add 7g of styrene monomer, 1.25g of benzyl bromide, 0.5g of cuprous bromide and 2g of bipyridine to a 50ml flask, bubbling with nitrogen for 30 minutes, seal it, and put it in 110℃ oil In the bath, react for 3 hours. Add a small amount of tetrahydrofuran to dissolve, throw into a large amount of methanol for precipitation twice, and dry in a vacuum oven at 50°C for 1 day to obtain polystyrene with a molecular weight of 2000.
[0034] The second step: add 2 g of anhydrous potassium carbonate and 1 g of p-hydroxybenzaldehyde to the 3 g of polystyrene solution in acetone obtained above, and reflux for 1 day at 60°C. After filtering, concentrating the solution, precipitating a large amount of methanol for 3 times, and drying in vacuum at 50°C, polystyrene with aldehyde groups can be obtained.
[0035] The third step: Dissolve 20 mg of the above polystyrene and 10 mg of monomethyl polyethylene glycol (molecular weight 1000) with a hydrazide terminal in...
Example Embodiment
[0038] Example 2
[0039] Step 1: Add 7g of styrene monomer, 1.25g of benzyl bromide, 0.5g of cuprous bromide and 2g of bipyridine to a 50ml flask, bubbling with nitrogen for 30 minutes, seal it, and put it in 110℃ oil In the bath, react for 3 hours. Add a small amount of tetrahydrofuran to dissolve, throw into a large amount of methanol for precipitation twice, and dry in a vacuum oven at 50°C for 1 day to obtain polystyrene with a molecular weight of 2000.
[0040] The second step: add 2 g of anhydrous potassium carbonate and 1 g of p-hydroxybenzaldehyde to the 3 g of polystyrene solution in acetone obtained above, and reflux for 1 day at 60°C. After filtering, concentrating the solution, precipitating a large amount of methanol, and vacuum drying at 50°C, polystyrene with aldehyde groups can be obtained.
[0041] Step 3: Dissolve 20 mg of the above polystyrene and 5 mg of monomethyl polyethylene glycol (molecular weight 550) with a hydrazide bond at the end in 12.5 ml of dimeth...
Example Embodiment
[0044] Example 3
[0045] The first step: Add 7g of styrene monomer, 0.5g of benzyl bromide, 0.5g of cuprous bromide and 2g of bipyridine to a 50ml flask, bubbling with nitrogen for 30 minutes, seal it, and put it in 110℃ oil In the bath, react for 3 hours. Add a small amount of tetrahydrofuran to dissolve, throw into a large amount of methanol for precipitation twice, and dry in a vacuum oven at 50°C for 1 day to obtain polystyrene with a molecular weight of 3000.
[0046] The second step: Add 2 g of anhydrous potassium carbonate and 0.8 g of p-hydroxybenzaldehyde to the 3 g of polystyrene solution in acetone obtained above, and reflux at 60°C for 1 day. After filtering, concentrating the solution, precipitating a large amount of methanol, and vacuum drying at 50°C, polystyrene with aldehyde groups can be obtained.
[0047] The third step: Dissolve 15 mg of the above polystyrene and 10 mg of monomethyl polyethylene glycol (molecular weight 2000) with a hydrazide bond at the end i...
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