Preparation method for pH controlled releasedynamic polymer packaging system

A controlled release and polymer technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of abnormal rapidity, uncontrollable release, and difficulty in dissociation, etc. problems, to achieve the effect of broad application prospects

Inactive Publication Date: 2009-01-14
SHANGHAI JIAO TONG UNIV
View PDF0 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the above-mentioned self-assembly system can change the assembly morphology under the regulation of solution pH value, salt and other factors (Jiang Ming, A. Eisenberg, Liu Guojun, Zhang Xi et al., Macromolecular Self-Assembly, 2006, Science Press), but because its polymer molecular chains are all strongly covalently linked, in an aqueous sol

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for pH controlled releasedynamic polymer packaging system
  • Preparation method for pH controlled releasedynamic polymer packaging system
  • Preparation method for pH controlled releasedynamic polymer packaging system

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0032] Example 1

[0033] Step 1: Add 7g of styrene monomer, 1.25g of benzyl bromide, 0.5g of cuprous bromide and 2g of bipyridine to a 50ml flask, bubbling with nitrogen for 30 minutes, seal it, and put it in 110℃ oil In the bath, react for 3 hours. Add a small amount of tetrahydrofuran to dissolve, throw into a large amount of methanol for precipitation twice, and dry in a vacuum oven at 50°C for 1 day to obtain polystyrene with a molecular weight of 2000.

[0034] The second step: add 2 g of anhydrous potassium carbonate and 1 g of p-hydroxybenzaldehyde to the 3 g of polystyrene solution in acetone obtained above, and reflux for 1 day at 60°C. After filtering, concentrating the solution, precipitating a large amount of methanol for 3 times, and drying in vacuum at 50°C, polystyrene with aldehyde groups can be obtained.

[0035] The third step: Dissolve 20 mg of the above polystyrene and 10 mg of monomethyl polyethylene glycol (molecular weight 1000) with a hydrazide terminal in...

Example Embodiment

[0038] Example 2

[0039] Step 1: Add 7g of styrene monomer, 1.25g of benzyl bromide, 0.5g of cuprous bromide and 2g of bipyridine to a 50ml flask, bubbling with nitrogen for 30 minutes, seal it, and put it in 110℃ oil In the bath, react for 3 hours. Add a small amount of tetrahydrofuran to dissolve, throw into a large amount of methanol for precipitation twice, and dry in a vacuum oven at 50°C for 1 day to obtain polystyrene with a molecular weight of 2000.

[0040] The second step: add 2 g of anhydrous potassium carbonate and 1 g of p-hydroxybenzaldehyde to the 3 g of polystyrene solution in acetone obtained above, and reflux for 1 day at 60°C. After filtering, concentrating the solution, precipitating a large amount of methanol, and vacuum drying at 50°C, polystyrene with aldehyde groups can be obtained.

[0041] Step 3: Dissolve 20 mg of the above polystyrene and 5 mg of monomethyl polyethylene glycol (molecular weight 550) with a hydrazide bond at the end in 12.5 ml of dimeth...

Example Embodiment

[0044] Example 3

[0045] The first step: Add 7g of styrene monomer, 0.5g of benzyl bromide, 0.5g of cuprous bromide and 2g of bipyridine to a 50ml flask, bubbling with nitrogen for 30 minutes, seal it, and put it in 110℃ oil In the bath, react for 3 hours. Add a small amount of tetrahydrofuran to dissolve, throw into a large amount of methanol for precipitation twice, and dry in a vacuum oven at 50°C for 1 day to obtain polystyrene with a molecular weight of 3000.

[0046] The second step: Add 2 g of anhydrous potassium carbonate and 0.8 g of p-hydroxybenzaldehyde to the 3 g of polystyrene solution in acetone obtained above, and reflux at 60°C for 1 day. After filtering, concentrating the solution, precipitating a large amount of methanol, and vacuum drying at 50°C, polystyrene with aldehyde groups can be obtained.

[0047] The third step: Dissolve 15 mg of the above polystyrene and 10 mg of monomethyl polyethylene glycol (molecular weight 2000) with a hydrazide bond at the end i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method of a dynamic polymer packaging system of pH regulation and release, which belongs to the chemical industry field. The invention is characterized in that hydrophobic polymer and hydrophilic polymer are linked to form a block dynamic copolymer by adopting dynamic chemical bond, through dissolving the dynamic copolymer and hydrophobic dye or drug molecule in co-solvent, and in the case that precipitator is slowly added, the solution of the polymer assembled body packaged with the dye or the drug molecule is formed. The preparation method of the invention can realize the controllable release of dyes or drug molecules with the regulation and the control of pH value, thus the preparation method has broad application prospect in the aspects of drug delivery and dye release.

Description

technical field [0001] The invention relates to a preparation method in the technical field of chemical engineering, in particular to a preparation method of a pH-regulated release dynamic polymer encapsulation system. Background technique [0002] Dynamic polymers refer to polymers linked by dynamic chemical bonds. Dynamic chemical bond is a kind of chemical bond proposed in recent years, and its bond energy is between covalent bond and non-covalent bond. Compared with covalent bonds, such chemical bonds have the characteristics of reversible formation / breaking under mild conditions; compared with non-covalent bonds, such chemical bonds are more stable. Acylhydrazone bond (-CO-NH-N=CH-), imine bond (-N=CH-), ester bond (-CO-O-), disulfide bond (-S-S-), etc. belong to dynamic chemical bonds scope. The current research based on reversible covalent bonds is progressing rapidly. For example, the French Nobel laureate Lehn et al. prepared covalent dynamic polymers based on ac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C09B67/00C09B67/14C08L87/00C08K5/3467C08G81/02A61K47/34A61K31/337A61K31/704A61P35/00
Inventor 蒋逸朱琦石云峰朱新远颜德岳
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products