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Method for preparing photo-stable methylamino avermectin

A technology of methylamino abamectin acrylate and methylamino abamectin, applied in the field of preparation of methylamino abamectin polyacrylate, can solve the problem of easy decomposition, poor stability, impact on development and Use and other issues to achieve the effect of improving light stability

Active Publication Date: 2011-02-09
HEBEI VEYONG BIO CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Emamectin has high biological activity against various crop pests, and its unique mechanism of action can effectively control pests that are resistant to commonly used insecticides. One of the pesticide varieties, its structure is a glycoside formed by a sixteen-membered macrocyclic lactone and a disaccharide (oleanose), and the original hydroxyl group is replaced with a methylamino group at the 4″ position. Many parts in the structure, such as ether bonds and ester groups, are photolytically active parts, so emamectin is sensitive to temperature, ultraviolet light and other factors, has poor stability, and is easy to decompose when used, which affects to a large extent its development and utilization
The way to improve the photostability of pesticides in the existing pesticide preparation technology is usually to add photostabilizers through physical methods, but this method is not effective for improving the photostability of emamectin. Abamectin preparation photolysis is very fast, it is difficult to meet the normal use requirements

Method used

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  • Method for preparing photo-stable methylamino avermectin
  • Method for preparing photo-stable methylamino avermectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Preparation of the acylated product of abamectin:

[0017] The following raw materials are used in parts by weight: 10 parts of abamectin, 3 parts of acryloyl chloride, 216 parts of dichloromethane, and 3 parts of triethylamine.

[0018] Preparation method: Dissolve emamectin in dichloromethane, cool to 0°C with an ice-water bath, then add acryloyl chloride dropwise at a uniform speed under stirring, and adjust the pH value of the reaction solution with triethylamine at any time, Keep it neutral, and react for 10 hours to obtain a reaction solution. Add distilled water to the reaction solution for purification, and extract the water layer with dichloromethane, wash the collected liquid twice with distilled water, then dry it with magnesium sulfate, evaporate the collected liquid under reduced pressure with a rotary evaporator, and obtain the product—light yellow Solid crystallization of the acryloylation product of emamectin. Finally, purification was carried out b...

Embodiment 2-8

[0023] 1. Preparation of the acylated product of abamectin: adopt the following raw materials in parts by weight,

[0024]

[0025] Abamectin

[0026] The preparation method is the same as the corresponding steps in Example 1, and finally the solid crystal of the acrylylated product of emamectin is obtained.

[0027] 2, the preparation of emamectin polyacrylate nanoparticles: adopt the following raw materials in parts by weight,

[0028]

[0029] lauryl methacrylate

[0030] The difference between the preparation method and the corresponding steps of Example 1 is that

Embodiment 2

[0031] Embodiment 2: The remaining parts of deionized water are heated so that the temperature is controlled at 90°C. Evenly add the retarder mixture into the heated deionized water, start to add the pre-emulsion evenly into the deionized water after 5 minutes, control the addition time to 2 hours, keep it warm for 30 minutes, then cool down, and discharge, you can get the method prepared by the present invention The product-light-stable emamectin polyacrylate.

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Abstract

The invention discloses a method for preparing an emamectin benzoate which is stable against light. The method comprises the following steps: 1. in dichloromethane, performing the propene acylation reaction of the emamectin benzoate, an acylation agent and an acid-binding agent on the emamectin benzoate to obtain reaction liquid; 2. extracting and evaporating the reaction liquid to obtain emamectin benzoate acryloyl ; 3. adding a mixed monomer of the emamectin benzoate acryloyl and an acrylic ester to an emulsifier aqueous solution formed by an emulsifier for pre-emulsification; and 4. addingthe mixed solution with a retarding agent to the pre-emulsification solution so as to obtain aqueous disperse liquid of polyacrylic acid nanometer particles of the emamectin benzoate through polyreaction, and then performing the emulsion breaking treatment on the aqueous disperse liquid by acid methanol to obtain a finished product. With the method the crude drug of the emamectin benzoate is connected with a polymer nanometer particle structure which is stable against light through a covalent bond; in addition, the method prevents the emamectin benzoate from degradation caused by direct illumination under the protection of a polymer nanometer particle ligand, and further improves the light stability of emamectin benzoate.

Description

technical field [0001] The invention relates to a method for pesticide preparation, in particular to a method for preparing light-stable methylaminoabamectin polyacrylate. Background technique [0002] Emamectin has high biological activity against various crop pests, and has a unique mechanism of action. It can effectively control pests that are resistant to commonly used insecticides. It is an ideal method in the current integrated agricultural pest control One of the pesticide varieties, its structure is a glycoside formed by a sixteen-membered macrocyclic lactone and a disaccharide (oleanose), and the original hydroxyl group is replaced with a methylamino group at the 4″ position. Many parts in the structure, such as ether bonds and ester groups, are photolytically active parts, so emamectin is sensitive to temperature, ultraviolet light and other factors, has poor stability, and is easy to decompose when used, which affects to a large extent The development and utiliza...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08A01N43/90A61P7/00
Inventor 尚青史磊史永利尹继丰
Owner HEBEI VEYONG BIO CHEM