Method for preparing farina microcapsule medicament

A technology for pollen sac and pollen, which is applied in microcapsules, pharmaceutical formulations, capsule delivery and other directions, can solve the problems of lack, low success rate, easy to produce waste products from encapsulation, etc., and achieves prevention of oxidative deterioration, stable drug properties, and stable appearance. Effect

Inactive Publication Date: 2009-04-08
南京大渊美容保健有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Before the present invention, in the actual microencapsulation process, there were complex microencapsulation processing equipment, and the process was complicated and the success rate was not high. The operation proficiency has a great influen

Method used

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  • Method for preparing farina microcapsule medicament
  • Method for preparing farina microcapsule medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Active ingredients (calcium ions and HPO4 2- ) respectively diffuse into the interior of the pollen sac, and the inorganic substances produced by selective chemical reactions in the interior of the pollen have an average diameter larger than the pollen bud pores, and the particles remain in the pollen sac.

[0026] Calcium hydrogen phosphate is placed in pollen microcapsules and produced by the following reaction: Ca 2+ +HPO4 2- →CaHPO 4 . The microsomes can be used to supplement food nutrition, slow release and improve the bioavailability of calcium and supplement other minerals. This method includes the following four steps:

[0027] (a) Soak the dried pollen suspension in solvent A (containing 18% CaCl 2 10% aqueous ethanol solution), stirred at room temperature for 2 hours, and put solvent A into the pollen;

[0028] (b) Quickly wash and filter the pollen containing solvent A with a pure solvent (such as absolute ethanol or deionized water, etc.) to remove exc...

Embodiment 2

[0033] Organic substances (methylene blue and sodium fluorescein) diffuse into the interior of the anther respectively, and a chemical reaction occurs inside the pollen to produce a large amount of organic substances (low solubility), whose average diameter is larger than the pollen bud pores, and the organic substances are retained in the anther , this technique allows pollen microcapsule solvents to entrap organic drugs soluble in water or ethanol. The method of inserting organic material into the pollen sac involves the following four steps:

[0034] (a) Suspend and soak the dried pollen in solvent C (10% ethanol aqueous solution containing 0.5% methylene blue), stir at room temperature for 2 hours, and put solvent C into the pollen;

[0035] (b) Quickly wash and filter the pollen containing solvent C with a pure solvent (such as absolute ethanol or deionized water, etc.) to remove excess solvent C. Then suspend and soak it in solvent D (an aqueous solution of fluorescein ...

Embodiment 3

[0039] The pollen microcapsule is used as a carrier, and the active ingredient (soybean isoflavones) diffuses into the interior of the anther, acts on the inner wall of the anther through physical methods (precipitation or adsorption), and remains in the anther. Such microsomes can be used for sustained release and enhanced bioavailability of drugs and active ingredients. The method of placing soybean isoflavones into the pollen sacs includes the following four steps:

[0040] (a) suspending and soaking the selected soybean isoflavones in 95% ethanol solution E, the weight ratio is (1: 2~4);

[0041] (b) Suspend and soak the selected pollen in solvent E, and stir for 30 minutes at room temperature.

[0042] (c) After standing still for 2 hours, a physical change occurs. Due to the adsorption of the inner wall of the anther, soybean isoflavones will gradually precipitate out on the inner wall of the anther;

[0043] (d) Centrifuge, then wash and filter with pure solvent deio...

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Abstract

The invention relates to a method for preparing a medicament by using a natural rape pollen microcapsule as a carrier. The method comprises the following steps: drying the natural rape pollen, using drugs or active components as substances embedded in a pollen sac, and diffusing the substances to the interior of the pollen sac through germ pores of the pollen sac, wherein the medicaments or the active components are remained in the interior of the pollen sac after physical or chemical reactions, and are dried at lower temperature after centrifugation to be prepared into a pollen microcapsule drug. The method solves the defects that the prior method needs complicated microencapsulation equipment and has complicated process and low success rate, is lack of a simple encapsulating method applicable to all capsule cores, is not continuous in an operation method, is not advantageous to joint production, and generates wastes during packaging capsule. The method has the advantages: firstly, aready-made pollen sac is used, the external form of the pollen sac is stable, and the microcapsule is does not need to be made over again, thus the steps and process for preparing the microcapsule are saved; secondly, the pollen microcapsule is not affected by the filled substances and the solvent thereof,, and the ranges of drug loading and active components are wide; and thirdly, the microcapsule drug has stable property, and basically generates no waste.

Description

technical field [0001] The invention relates to a solvent embedding technique, in particular to a medicine preparation method using natural rape pollen microcapsules as a carrier. Background technique [0002] Microcapsules are microcapsules with a particle size of 5-500 μm formed by embedding solid or liquid drugs with natural or synthetic polymer materials. Microcapsules can be prepared into powders, granules, capsules, tablets, injections and other dosage forms, so that they can delay drug release, improve drug stability, mask bad odor, reduce gastrointestinal side effects, and reduce compound drugs. Incompatibility, improve the physical properties of some drugs (such as compressibility, fluidity), can make liquid drugs into solid preparations, and play a targeting role. [0003] The process of preparing microcapsules is called microencapsulation technology, referred to as microencapsulation, the wrapped drug is called capsule core, and the polymer material used to wrap ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/46
Inventor 刘爱国
Owner 南京大渊美容保健有限公司
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