Use of arjunolic acid in preparing glycosidase inhibitor
A technology of glycosidase inhibitor, terminalisoleic acid, which is applied in the field of natural medicinal chemistry to achieve the effects of low pollution, convenient extraction and environmental friendliness
Inactive Publication Date: 2009-04-29
ZHEJIANG UNIV
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The invention provides the application of arjunolic acid or salts thereof suitable for medical purpose in the preparation of a drug of an Alpha-glucosidase inhibitor. The invention is characterized in that strong effective Alpha-glucosidase inhibitor is extracted and separated from lagerstroemia plants which has rich source, are easy to be extracted and can be recycled for a plurality of times, thus not only promoting economic benefit, but also being environment-friendly. Furthermore, the monomeric compound product of the Alpha-glucosidase inhibitor is stable and is convenient to be stored. Pharmacological tests prove that the arjunolic acid has powerful effect in inhibiting Alpha-glucosidase, wherein, physiological change or diseases caused by or related to the Alpha-glucosidase includes but is not limited to Type II Diabetes. The monomeric compound product of the Alpha-glucosidase inhibitor can be further developed into the drugs for clinically treating NIDDM, thereby having better prospect for marketization. The constitutional formula of compound of the arjunolic acid is shown as above.
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