Health product oral fast-release preparation and production method thereof

A technology for immediate-release preparations and manufacturing methods, applied in food preparation, application, food science and other directions, can solve the problems of low tablet strength, limited dosage of main drugs, large dosage of auxiliary materials, etc., and achieves improved dispersion rate and raw material adaptability. Wide and large drug loading effect

Active Publication Date: 2009-06-03
何煜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many defects in these preparations, such as: granular feeling after disintegration, complicated preparation method, excessive water absorption is difficult to store, low tablet strength, etc.
Because the rapid release of the tablet is inversely proportional to the strength of the tablet, the amount of excipients is large and the amount of the main drug is limited
These dosage forms rely entirely on a small amount of water in the mouth to produce immediate release. When the saliva in the mouth is insufficient, the tablet will adhere to the oral mucosa and cause discomfort.
These problems are difficult to break through in the existing preparation mode

Method used

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  • Health product oral fast-release preparation and production method thereof
  • Health product oral fast-release preparation and production method thereof
  • Health product oral fast-release preparation and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] Embodiment 1: the manufacture of pear paste preparation

[0141] (1) Prepare ingredients: main ingredients (take 38 parts of Liqing Gao, 6 parts of Chuan Fritillaria, 10 parts of Ophiopogon japonicus, 3 parts of Lily, and 3 parts of Coltsfoot Flower. Add 7 times the amount of water to the medicinal materials except Li Qing Gao, fry Boil and extract 2 times, each time for 1 hour, combine the two extracts, filter, add pear clear paste to concentrate to a relative density of 1.05-1.10, add 10 parts of dextrin and mix well, and spray dry to powder) 200kg, excipients (xylitol 300kg, refined vegetable oil 200kg, lecithin 10kg)

[0142] (2) Slurry preparation: refinement first - using semi-dry method, roller grinding method (see Image 6 ). Specifically: add 200kg of main ingredients to 300kg of xylitol powder (60-120 mesh) and 130kg of refined vegetable oil (39-62°C), mix them, and grind them in a five-roll mill (or three-roll mill) to 22-30 microns. Then liquefy—put the m...

Embodiment 2

[0144] Embodiment 2: the manufacture of snow clam Cordyceps preparation

[0145] (1) Material preparation: main ingredients (100 parts of snow clam, 3 parts of Cordyceps mycelium) 160kg, auxiliary materials (30kg of isomaltose, 100kg of isomalt, 100kg of refined palm oil, 2kg of lecithin)

[0146] (2) Slurry preparation: refinement first - using semi-dry method, roller grinding method (see Image 6 ). Specifically: mix 160kg of main ingredients with 30kg of isomaltooligosaccharide, 100kg of isomalt and 80kg of refined palm oil (37-48°C), and pre-grind in a two-roll mill (or three-roll mill) to 70-160 microns , and then enter the five-roll mill (or three-roll mill) for grinding to 16-28 microns. Then liquefy—put the material into a refiner (blender) for refining (stirring) for 5 to 7 hours, during which lecithin and the remaining refined palm oil are gradually added according to the viscosity of the material.

[0147] (3) Molding: After refining (stirring), discharge the mat...

Embodiment 3

[0148] Embodiment 3: the manufacture of acid enzyme preparation

[0149] (1) Material preparation: main ingredients 200kg (100 parts of black plum, 100 parts of hawthorn, 10 parts of licorice, 7 parts of sweet-scented osmanthus. Add 7 times the amount of the above materials, boil and extract twice, each time for 1 hour, combine the two extractions Liquid, filtered, concentrated to a relative density of 1.05-1.10, then added 30 parts each of dextrin and lactose, mixed evenly, and spray-dried into powder), auxiliary materials (sugar 700kg, refined coconut oil 480kg, lecithin 20kg)

[0150] (2) Slurry preparation: refinement and liquefaction at the same time - using wet method and fine grinding method (see Figure 7 ). Specifically: Add 390kg of refined coconut oil (36-60°C), 700kg of powdered sugar and main ingredients to a scraper-type refiner and grind until they reach 22-26 microns, then add the remaining refined coconut oil and lecithin until uniform.

[0151] (3) Molding:...

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Abstract

The invention relates to a health product oral fast-release preparation and a production method thereof. The basic raw material of the preparation comprises main material and auxiliary material. The main material is health product raw material. The auxiliary material is oily dispersant mainly, and water-soluble dispersant, flavouring and emulsifier are added when necessary. The weight percentage of the main material is 0.1 percent to 80 percent, and the weight percentage of the auxiliary material is 20 percent to 99.9 percent. The method comprises the following steps: (1) preparing materials;(2) preparing slurry, including thinning and liquidizing, the finial fineness of the thinning is that 80 percent of the weight of the preparation is less than 300 microns, and the liquidizing processis that solid particles are dispersed in the oily dispersant in a stirring way. The weight percentage of the addition quantity of the oily dispersant can satisfy that the oil content in a finished product is not less than 15 percent; (3) molding that a finished product preparation is manufactured by a cooling molding method or a powder molding method. The health product oral fast-release preparation of the invention improves the dispersing speed of health product component in mouth under the precondition of achieving good flavor and is convenient for people to take without drinking water.

Description

(1) Technical field: [0001] The invention provides a health product oral quick-release preparation and a manufacturing method thereof, belonging to the technical field of health product preparations. The health food mentioned in this patent can be health food, functional food, health food, supplementary food, enhanced food, new resource food, nutritional product or other food forms. [0002] This preparation is specially labeled or advertised to provide special nutrients or have specific health effects, rather than food for the purpose of treating and correcting human diseases. (two) background technology: [0003] Existing health care products generally adopt the preparation method of western medicine, such as capsules, tablets, oral liquids, granules, etc. The main components of health care products come from a wide range of sources, with large differences. Most consumers are healthy or sub-healthy people. The demand for taste and convenience is much higher than that of m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/03A23L1/30A23L33/10
Inventor 何煜
Owner 何煜
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