Detection method for cis-isomer in vitamin K2 medicine

A cis-isomer and detection method technology, applied in the field of detection of vitamin K2 drug impurities, can solve the problems of low precision, inability to accurately control the content of cis-isomer, poor specificity, etc., achieve high sensitivity, facilitate Promotional use, good specific effect
CN101470104AInactive Publication Date: 2009-07-01天津康鸿医药科技发展有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
天津康鸿医药科技发展有限公司
Publication Date
2009-07-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a high efficiency liquid chromatography detection method for cis isomer in vitamin K2 medicines, which adopts a normal phase chromatography column stuffed by silica gel, and a flow phase formed by one low-polarity solvent selected from hexane, pentane, petroleum ether, cyclohexane, isooctane and heptane, and one high-polarity solvent selected from butyl ether, isopropanol, pentanol, n-pentanol, tetrahydrofuran, dichloromethane and ethanol. The high efficiency liquid chromatography detection method has high sensitivity and specialization, having simple operation, high repeatability, which is beneficial for controlling the quality of raw materials and agents in production.
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Description

technical field

[0001] The invention relates to a method for detecting impurities in vitamin K2 drugs, in particular to a method for detecting cis-isomers in vitamin K2 drugs. Background technique

[0002] With the extension of human life span, population aging has brought new problems to human health. Osteoporosis and the fractures it causes rank seventh among the current common diseases, seriously threatening the health of middle-aged and elderly people.

[0003] Studies have confirmed that vitamin K2 drugs have osteogenic effects, promote calcium metabolism, and at the same time inhibit bone resorption caused by osteoclasts, thereby increasing bone density and preventing osteoporosis. Menatetrenone, as a kind of vitamin K2 drugs, has a strong procoagulant effect (approved in 1972 as a procoagulant drug). Menatetrenone also has two effects of promoting osteogenesis and inhibiting bone resorption. It can not only activate osteoblasts and promote calcification, but also in...

Claims

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