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Sodium hyaluronate contained flexible hydrophilic contact lens and method for producing the same

A sodium hyaluronate, contact lens technology, applied in glasses/goggles, other household appliances, applications, etc., to achieve the effect of improving easy dehydration, wearing comfort, and slowing the evaporation of water

Active Publication Date: 2009-07-15
GUANGZHOU BAOSHINING OPTICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report about the application of sodium hyaluronate as a moisturizing substance in soft hydrophilic contact lens materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] By weight percentage, the comonomer raw material formula of the soft hydrophilic contact lens containing sodium hyaluronate is:

[0038] Hydroxyethyl Methacrylate 70%

[0039] N-vinylpyrrolidone 20%

[0040] Glycidyl Methacrylate 4%

[0041] Methyl methacrylate 5%

[0042] (Bis) ethylene glycol methacrylate 0.15%

[0043] UV absorber (2-hydroxybenzophenone ethylene ether acrylate) 0.62%

[0044] Azobisisoheptanonitrile 0.2%

[0045] Vat bleached blue dye BC (produced by Shanghai Huayuan Industrial Corporation) 0.03%

[0046] Then add 0.2% sodium hyaluronate aqueous solution with 10% of the total weight of the above-mentioned comonomers.

[0047] The different addition amounts of the sodium hyaluronate aqueous solution are calculated when the total amount of comonomers is 100%.

[0048] A method for preparing a soft hydrophilic contact lens containing sodium hyaluronate, comprising the steps of:

[0049] The preparation method of the soft hydrophilic contact lens...

Embodiment 2

[0057] By weight percentage, the comonomer raw material formula of the soft hydrophilic contact lens containing sodium hyaluronate is:

[0058] Hydroxyethyl Methacrylate 80%

[0059] N-Vinylpyrrolidone 10%

[0060] Glycidyl Methacrylate 6%

[0061] Ethyl methacrylate 3%

[0062] (Bis) ethylene glycol methacrylate 0.11%

[0063] UV absorber (2-hydroxybenzophenone ethylene ether acrylate) 0.62%

[0064] Azobisisoheptanonitrile 0.2%

[0065] Vat bleached blue dye BC (produced by Shanghai Huayuan Industrial Corporation) 0.03%

[0066] Then add 0.2% sodium hyaluronate aqueous solution with 15% of the total weight of the above-mentioned comonomers.

[0067] The preparation method of the soft hydrophilic contact lens containing sodium hyaluronate comprises the following steps:

[0068] (1) Preparation: add 0.2g sodium hyaluronate to 100ml pure water, stir overnight at 5-10°C, and prepare 0.2% (w / w) sodium hyaluronate aqueous solution; accurately weigh and remove hyaluronic aci...

Embodiment 3

[0075] By weight percentage, the comonomer raw material formula of the soft hydrophilic contact lens containing sodium hyaluronate is:

[0076] Hydroxyethyl Methacrylate 78%

[0077] N-vinylpyrrolidone 15%

[0078] Glycidyl Methacrylate 3%

[0079] Ethyl methacrylate 3%

[0080] (Bis) ethylene glycol methacrylate 0.11%

[0081] UV absorber (2-hydroxybenzophenone ethylene ether acrylate) 0.69%

[0082] Azobisisoheptanonitrile 0.2%

[0083] Vat bleached blue dye BC (produced by Shanghai Huayuan Industrial Corporation) 0.03%

[0084] Then add 0.2% sodium hyaluronate aqueous solution with 10% of the total weight of the above-mentioned comonomers.

[0085] The preparation method of the soft hydrophilic contact lens containing sodium hyaluronate comprises the following steps:

[0086] (1) Preparation: add 0.2g sodium hyaluronate to 100ml pure water, stir overnight at 5-10°C, and prepare 0.2% (w / w) sodium hyaluronate aqueous solution; accurately weigh and remove hyaluronic aci...

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Abstract

The invention discloses a flexible hydrophilic contact lens containing sodium hyaluronate and preparing method thereof, the flexible hydrophilic contact lens consists of comonomers composed of methyl methacrylate, ethyl methacrylate, N-ethenyl pyrrolidone, glyceryl methacrylate, (bi)glycol dimethacrylate, UV absorbing agent, azo-bis-iso-heptonitrile and reduction blue rinsing dye, also comprises 0. 1-0. 2(volume) of sodium hyaluronate water solution, when being preparing, mixing the above substances; arranging in a mould for heat polymerization and additional vulcanization; then machining, hydrating, extracting and cleaning to obtain the flexible hydrophilic contact lens. The sodium hyaluronate adopted in the invention is high hydrotropic substance and has high wetting property and moisture-keeping property. The sodium hyaluronate is added in the traditional flexible hydrophilic contact lens material system, which can improve the water content of the material and can improve the wetting property and the moisture-keeping property of the material surface, the wearing time of the wearer can be prolonged.

Description

technical field [0001] The invention relates to a soft hydrophilic contact lens, in particular to a soft hydrophilic contact lens containing sodium hyaluronate and a preparation method thereof. Background technique [0002] Sodium hyaluronate is a chain polymer composed of repeated connections of disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine, with an average molecular weight of 10 6 ~10 7 . It can be extracted from animal vitreous, umbilical cord, skin, joint synovial fluid, cockscomb and streptococcus bacteria. Because it is a biological extract, its toxicity is extremely low, and it has minimal irritation to the skin and mucous membranes. In addition, based on its unique rheological properties and colligative properties, it is widely used in various ophthalmic preparations as a moisturizer. [0003] Soft hydrophilic contact lens materials are usually composed of hydrophilic organic monomers, hydrophobic organic monomers and crosslinking agents. Hyd...

Claims

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Application Information

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IPC IPC(8): G02B1/04G02C7/04C08F251/00B29D11/00
Inventor 林冬青宋伟
Owner GUANGZHOU BAOSHINING OPTICAL PROD
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