Toltrazuril suspension preparation capable of being effectively uniformly dispersed in water and preparation method thereof

A technology of toltrazuril and suspension, applied in the directions of effective components of heterocyclic compounds, liquid delivery, emulsion delivery, etc., can solve the problem of high cost relative to aqueous solutions, poor stability of toltrazuril, and difficult to control quality, etc. problem, to achieve the effect of improving bioavailability, prolonging residence time, and low toxicity

Inactive Publication Date: 2009-07-29
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. The cost of auxiliary materials is high: the amount of organic solvent is large, and the cost is relatively high compared to aqueous solution
[0007] 2. High manufacturing cost: the manufacturing process requires heating and cooling, consumes a lot of energy, an

Method used

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  • Toltrazuril suspension preparation capable of being effectively uniformly dispersed in water and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0040] Example 1:

[0041] Components:

[0042] Toltrazuril 5.0g

[0043] Sodium octyl butyl sulfonate 0.25g

[0044] Dimethicone 0.05g

[0045] Sodium propionate 0.20g

[0046] Benzoic acid 0.20g

[0047] Magnesium aluminum silicate 0.35g

[0048] Anhydrous citric acid 0.60g

[0049] Xanthan gum 0.30g

[0050] 1,2-Propanediol 10.0g

[0051] Purified water 83.0g

[0052] Configuration method:

[0053] (1) Take 30 g of purified water, add 0.20 g of sodium propionate, 0.20 g of benzoic acid and 0.6 g of anhydrous citric acid, stir and dissolve to obtain solution A.

[0054] (2) Take 30g of purified water, add 0.3g of xanthan gum and stir evenly, then puff to obtain solution B

[0055] (3) Pour solution B into solution A. After stirring evenly, add 0.25g of sodium octbutyl sulfonate and stir for 10 minutes, then add 0.05g of dimethyl silicone oil, 10g of 1,2-propanediol, and magnesium aluminum silicate. 0.35g, toltrazuril 5g, after stirring and mixing, 26.5g purified water was added ...

Example Embodiment

[0058] Example 2:

[0059] Components:

[0060] Toltrazuril 2.5g

[0061] Sodium dodecyl sulfonate 0.18g

[0062] Tween 80 0.50g

[0063] Methyl Paraben 0.21g

[0064] Ethyl Paraben 0.21g

[0065] Magnesium aluminum silicate 0.35g

[0066] Sodium citrate 0.50g

[0067] Sodium carboxymethyl cellulose 1.13g

[0068] 1,2-Propanediol 8.6g

[0069] Purified water 86.5g

[0070] Configuration method:

[0071] (1) Take 30 g of purified water, add 0.21 g of sodium propionate, 0.21 g of benzoic acid and 0.5 g of sodium citrate, stir and dissolve to obtain solution A.

[0072] (2) Take 30 g of purified water, add 0.5 g of sodium carboxymethyl cellulose and stir evenly, then expand to obtain solution B

[0073] (3) Pour solution B into solution A. After stirring evenly, add 0.18g of sodium lauryl sulfonate and stir for 10 minutes, then add 800.5g of Tween, 8.6g of 1,2-propanediol, and magnesium aluminum silicate. 0.35g and 2.5g of toltrazuril, after stirring and mixing, 26.5g of purified wate...

Example Embodiment

[0076] Example 3:

[0077] Components:

[0078] Toltrazuril 15.0g

[0079] Sodium octbutyl sulfonate 0.53g

[0080] Dimethicone 0.07g

[0081] Sodium propionate 0.20g

[0082] Benzoic acid 0.20g

[0083] Magnesium aluminum silicate 0.38g

[0084] Anhydrous citric acid 0.90g

[0085] Xanthan gum 0.48g

[0086] 1,2-Propanediol 12.1g

[0087] Glycerin 4.2g

[0088] Purified water 65.94g

[0089] Configuration method:

[0090] (1) Take 20 g of purified water, add 0.20 g of sodium propionate, 0.20 g of benzoic acid and 0.9 g of anhydrous citric acid, stir and dissolve to obtain solution A.

[0091] (2) Take 30g of purified water, add 0.48g of xanthan gum and stir evenly, then expand to obtain solution B

[0092] (3) Pour solution B into solution A. After stirring evenly, add 0.53g of sodium octylbutyl sulfonate and stir for 10 minutes, then add 0.07g of dimethyl silicone oil, 12.1g of 1,2-propanediol, and magnesium silicate in sequence 0.38 g of aluminum and 15 g of toltrazuril were st...

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Abstract

The invention discloses a Toltrazuril suspending agent dispersible in water and a method for preparing the same. The Toltrazuril suspending agent comprises 1 to 15 percent of Toltrazuril, 0.01 to 2.0 percent of a surfactant, 0.01 to 2.0 percent of an emulsifier, 0.1 to 0.3 percent of a preservative, 0.2 to 2.0 percent of a flocculant, 0.1 to 2.0 percent of a suspending aid, 1 to 20 percent of a wetting agent and 40 to 88 percent of purified water.

Description

technical field [0001] The invention relates to a toltrazuril suspension preparation and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a parasitic disease that seriously harms the poultry industry produced by Eimeria. There are 7 species of Eimeria parasitizing in chicken intestines, namely Eimeria tenella, E.acervulina, Eimeria poisonous ( E. necatrix), E. maxima, E. mitis, E. brinetti and E. precocious (E. .praecox). Various coccidia parasitize in different parts of the digestive tract of chickens. Eimeria tenella parasitizes in the cecum, Eimeria heaps parasitizes in the duodenum, Eimeria giant and Eimeria venom Parasitic in the small intestine, Eimeria brucei parasitizes in the lower small intestine and rectum. [0003] Chicken coccidiosis is a kind of parasitic disease that generally occurs all over the world and is very harmful to the chicken industry. The economic losses it caused were staggering. Among many mass diseases, ch...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/53A61P33/02
Inventor 刘爱玲
Owner TIANJIN RINGPU BIO TECH
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