Toltrazuril suspension preparation capable of being effectively uniformly dispersed in water and preparation method thereof
A technology of toltrazuril and suspension, applied in the directions of effective components of heterocyclic compounds, liquid delivery, emulsion delivery, etc., can solve the problem of high cost relative to aqueous solutions, poor stability of toltrazuril, and difficult to control quality, etc. problem, to achieve the effect of improving bioavailability, prolonging residence time, and low toxicity
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Example Embodiment
[0040] Example 1:
[0041] Components:
[0042] Toltrazuril 5.0g
[0043] Sodium octyl butyl sulfonate 0.25g
[0044] Dimethicone 0.05g
[0045] Sodium propionate 0.20g
[0046] Benzoic acid 0.20g
[0047] Magnesium aluminum silicate 0.35g
[0048] Anhydrous citric acid 0.60g
[0049] Xanthan gum 0.30g
[0050] 1,2-Propanediol 10.0g
[0051] Purified water 83.0g
[0052] Configuration method:
[0053] (1) Take 30 g of purified water, add 0.20 g of sodium propionate, 0.20 g of benzoic acid and 0.6 g of anhydrous citric acid, stir and dissolve to obtain solution A.
[0054] (2) Take 30g of purified water, add 0.3g of xanthan gum and stir evenly, then puff to obtain solution B
[0055] (3) Pour solution B into solution A. After stirring evenly, add 0.25g of sodium octbutyl sulfonate and stir for 10 minutes, then add 0.05g of dimethyl silicone oil, 10g of 1,2-propanediol, and magnesium aluminum silicate. 0.35g, toltrazuril 5g, after stirring and mixing, 26.5g purified water was added ...
Example Embodiment
[0058] Example 2:
[0059] Components:
[0060] Toltrazuril 2.5g
[0061] Sodium dodecyl sulfonate 0.18g
[0062] Tween 80 0.50g
[0063] Methyl Paraben 0.21g
[0064] Ethyl Paraben 0.21g
[0065] Magnesium aluminum silicate 0.35g
[0066] Sodium citrate 0.50g
[0067] Sodium carboxymethyl cellulose 1.13g
[0068] 1,2-Propanediol 8.6g
[0069] Purified water 86.5g
[0070] Configuration method:
[0071] (1) Take 30 g of purified water, add 0.21 g of sodium propionate, 0.21 g of benzoic acid and 0.5 g of sodium citrate, stir and dissolve to obtain solution A.
[0072] (2) Take 30 g of purified water, add 0.5 g of sodium carboxymethyl cellulose and stir evenly, then expand to obtain solution B
[0073] (3) Pour solution B into solution A. After stirring evenly, add 0.18g of sodium lauryl sulfonate and stir for 10 minutes, then add 800.5g of Tween, 8.6g of 1,2-propanediol, and magnesium aluminum silicate. 0.35g and 2.5g of toltrazuril, after stirring and mixing, 26.5g of purified wate...
Example Embodiment
[0076] Example 3:
[0077] Components:
[0078] Toltrazuril 15.0g
[0079] Sodium octbutyl sulfonate 0.53g
[0080] Dimethicone 0.07g
[0081] Sodium propionate 0.20g
[0082] Benzoic acid 0.20g
[0083] Magnesium aluminum silicate 0.38g
[0084] Anhydrous citric acid 0.90g
[0085] Xanthan gum 0.48g
[0086] 1,2-Propanediol 12.1g
[0087] Glycerin 4.2g
[0088] Purified water 65.94g
[0089] Configuration method:
[0090] (1) Take 20 g of purified water, add 0.20 g of sodium propionate, 0.20 g of benzoic acid and 0.9 g of anhydrous citric acid, stir and dissolve to obtain solution A.
[0091] (2) Take 30g of purified water, add 0.48g of xanthan gum and stir evenly, then expand to obtain solution B
[0092] (3) Pour solution B into solution A. After stirring evenly, add 0.53g of sodium octylbutyl sulfonate and stir for 10 minutes, then add 0.07g of dimethyl silicone oil, 12.1g of 1,2-propanediol, and magnesium silicate in sequence 0.38 g of aluminum and 15 g of toltrazuril were st...
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