Sitafloxacin sustained-release pellet and preparation method thereof

A technology of sitafloxacin and sustained-release pellets, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effects of reducing irritation and improving drug bioavailability
CN101496789AActive Publication Date: 2009-08-05CHONGQING LUMMY PHARMA
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Patent Information

Authority / Receiving Office
CN Ā· China
Current Assignee / Owner
CHONGQING LUMMY PHARMA
Publication Date
2009-08-05

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Abstract

The invention discloses a slow-release micropill of sitafloxacin, which comprises a slow-release drug-containing micropill, wherein the slow-release drug-containing micropill consists of a pill core of sitafloxacin and a slow-release coating layer; the pill core of sitafluoacin is coated with the slow-release coating layer; and the weight of the slow-release coating layer is 2 to 100 percent thatof the pill core of sitafloxacin. According to different coating materials and coating thicknesses, the slow-release micropill of sitafloxacin can be prepared into the micropills with different release curves, and according to clinical need, the preparation unit finally formed is added with one or more of the micropills with different release curves so as to achieve the best clinical effect.
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Description

technical field

[0001] The invention relates to a sitafloxacin sustained-release pellet and a preparation method thereof. Background technique

[0002] Sitafloxacin (Sitafloxacin) is a new type of oral quinolone antibiotics. The Japanese Ministry of Health and Welfare approved the broad-spectrum antibiotic sitafloxacin hydrate 50mg tablet and 10% fine granule (sitafloxacin hydrate) of Daiichi Sankyo Co., Ltd. , commercial Gracevit) marketed for severe and bacterial infections caused by drug-resistant bacteria. For most Gram-negative bacteria among more than 5,000 clinically isolated strains, sitafloxacin is more active than ciprofloxacin and ofloxacin; against Streptococcus pneumoniae, drug-resistant Staphylococcus aureus, Coccus, Enterococcus faecalis, Pseudomonas, etc. are more active than sparfloxacin, fleroxacin and ofloxacin; sitafloxacin is the compound with the strongest activity against Enterobacteriaceae. For the other tested strains, the activity of sitafloxacin ...

Claims

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