Method for extracting validamycin A raw powder from validamycin fermentation liquor

Abstract

The invention discloses a method for extracting validamycin A from validamycin fermentation liquor and refining the validamycin A. The method comprises the following steps: A. the validamycin fermentation liquor is directly handled by using a sawtooth ultrafiltration membrane system, the automatic control is adopted for the membrane system, and the output ultrafiltrate can directly enter in an ion exchange system after the validamycin fermentation liquor enters in the membrane system; B. cation exchange resin and anion exchange resin are selected and combined, and the foreign ions in the validamycin filtrate are removed; C. macroporous cation exchange resin is selected for absorbing the validamycin A, and the resin has good selectivity, large adsorbing capacity of the validamycin A, high mechanical strength and anti-pollution capability and long service life and is not easily broken; and D. due to the adoption of the PH gradient adsorption process, the PH value of the validamycin filtrate entering in the adsorption column is improved by using the ion exchange reaction balancing principle. The invention not only improves the adsorption efficiency and the saturated extent of adsorption of the adsorption resins, but also reduces the consumption of acid, alkali and water which are required by the anion resin (SX-14) and the activated resin and also improves the production efficiency.

Description

technical field [0001] The present invention relates to the technical field of producing high-content Jinggangmycin raw powder from Jinggangmycin fermentation liquid, and more specifically relates to a method for extracting Jinggangmycin A raw powder from Jinggangmycin fermentation liquid, which can be used to produce high-quality agricultural fungicides , can also be used as a pharmaceutical intermediate, and has strong competitiveness in the international market. Background technique [0002] Jinggangmycin (validamycin; validacin) is an efficient and safe agricultural antibiotic, mainly used to control rice sheath blight and wheat sheath blight. It is produced by fermentation of Streptomyces hygroscopicus Jinggang variety. It does not pollute the environment and is harmless to humans, animals and beneficial organisms. In 1972, the Shanghai Institute of Pesticides discovered a microorganism capable of producing Jinggangmycin—Streptomyces hygroscopicus var. Jinggang—in t...

AI Technical Summary

Problems solved by technology

The raw powder produced by this method has high impurity content, dark color, low active ingredient content, and the content of component A is generally lower than 30%. Generally, it can only be used to prepare low-end agricultural preparations, and cannot meet the high-end Jinggang in the international market. Quality Requirements for Mycin Preparations and Pharmaceutical Intermediate Grade Products

[0005] There are also some manufacturers in China who use ion exchange method to extract Jinggangmycin and produce Jinggangmycin raw powder with high content, but because the process is too simple and the removal of impurities is not complete, the content of component A in the raw powder is not more than 65%. , the average level can only reach about 55%, the content of inorganic salt and pigment in the raw powder is relatively high, and the whiteness is low

The raw powder produced by this process can be used to prepare agricultural preparations, but it cannot meet the quality requirements of pharmaceutical intermediate products

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