Polymethyl methacryate and crosslinking hyaluronic acid mixed gel for injection and preparation method thereof

A technology of polymethyl methacrylate and cross-linked hyaluronic acid, which is applied in the field of medicine, can solve the problems of long maintenance time and achieve the effects of long maintenance time, good plasticity and easy injection

Active Publication Date: 2009-08-12
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injected into the facial skin, the effect of eliminating wrinkles is good and lasts for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Using ethanol / water mixed solvent as the dispersion medium to prepare PMMA microspheres, refer to the method of literature (Hu Jie et al., Acta Polymerica Sinica, 2003, 4: 540-545), and change the conditions and ratio of polymerization to obtain suitable particle size. Dissolve 2.5g of polyvinylpyrrolidone (PVP) in 60ml of 55% ethanol solution, add 10g of methyl methacrylate, 1g of acrylic acid and 0.15g of azobisisobutyronitrile, blow nitrogen, pre-disperse for 30min, and raise the temperature to 70°C React for 50min, then lower the temperature to 55°C for 24h, finish the reaction, cool down to collect the dispersion, wash it repeatedly with ethanol / water, then centrifuge, and repeat the cycle 3 times, then use isotonic phosphate buffered saline (PBS) (each 1000ml contains NaH 2 .PO 4 2H 2 O 45 mg, Na 2 HPO 4 12H 2O 0.56g, NaCl 8.5g, pH 7.2) after soaking and washing repeatedly, centrifugal sedimentation to obtain microspheres with an average particle size ranging ...

Embodiment 2

[0040] Using the seed polymerization method, you can refer to the literature method (Sudol E D, El-Aasser M S, Vanderhoff J W.J PolymSci: Polym Chem, 1986, (24): 3499~3513), and appropriately change the conditions and proportions of the polymerization reaction to obtain the average particle size. PMMA microspheres with a diameter ranging from 10 to 30 μm. The microspheres were repeatedly washed with ethanol / water for more than 3 times, centrifugally settled, and then repeatedly soaked and washed with isotonic PBS, then centrifugally settled, and the obtained microspheres were used for future use.

[0041] Mix 10g of sodium hyaluronate (average molecular weight: 800,000 Daltons) with 70ml of 1% NaOH solution containing 0.5g of 1,4-butanediol diglycidyl ether, react at 50°C for 4h, and use deionized water at 70°C Purify at ℃ for 10 hours, extrude the gel to pass through a 60-mesh sieve, collect the gel particles, add an equal volume of PBS with 2 times the isotonic concentration...

Embodiment 3

[0051] Using the multi-step swelling polymerization method, you can refer to the literature method (Ckubo M, Shiozaki M, Tsujihiro M, FsukudaY. Colloid Polym Sci, 1991, (269): 222-226), and appropriately change the conditions and proportions of the polymerization reaction to obtain the average PMMA microspheres with a particle size range of 20-80 μm. The microspheres were repeatedly washed with ethanol / water for more than 3 times, centrifugally settled, and then repeatedly soaked and washed with isotonic PBS, then centrifugally settled, and the obtained microspheres were used for future use.

[0052] Mix 10g of sodium hyaluronate (average molecular weight: 520,000 Daltons) with 65ml of 1% NaOH solution containing 0.5g of 1,4-butanediol diglycidyl ether, react at 50°C for 4h, and use deionized water at 70°C Purify at ℃ for 10 hours, extrude the gel to pass through a 60-mesh sieve, collect the gel particles, add an equal volume of PBS with 2 times the isotonic concentration, and...

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PUM

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Abstract

The invention relates to a mixed gel consisting of polymethyl methacrylate and cross bonding hyaluronic acid, which is applied to injection, and a preparation method thereof; the mixed gel of the invention is characterized in that polymethyl methacrylate microballoon, cross bonding hyaluronic acid gel particles and hyaluronic acid or salting liquid thereof form the mixed gel, wherein, the polymethyl methacrylate microballoon accounts for 0.5-30% in terms of volume, volume ratio of the cross bonding hyaluronic acid gel particles and hyaluronic acid or salting liquid thereof ranges from 1:19 to19:1. The method for preparing the mixed gel comprises respectively preparing the polymethyl methacrylate microballoon and cross bonding hyaluronic acid gel particles, then evenly mixing the microballoon and the gel particles with hyaluronic acid or salt thereof dissolved in isosmotic solution, the sterilizing and packaging the mixture to obtain the finished product. The mixed gel of the invention can be used to prepare injection applied to beauty care and medical treatment and is a highly effective and lasting moulding material, which has the advantages of less side-effect and low incidence rate of anaphylactic reaction.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a mixed gel of polymethyl methacrylate and cross-linked hyaluronic acid for injection and a preparation method thereof. More specifically, the present invention relates to a mixed gel of polymethyl methacrylate and cross-linked hyaluronic acid that can be injected into skin soft tissue and joint cavity, its product, and its application in the cosmetic and medical fields. Background technique [0002] Polymethyl methacrylate (PMMA) is an acrylic resin polymer, which has the advantages of safety, stability, inertness and non-irritation, and has been widely used in bone cement, artificial joints, dentures, artificial eyes, hard High-quality contact lenses, intraocular lenses, and matrix slow-release materials. As early as the 1980s, French scientists proved that PMMA has good biocompatibility with the human body. Its clinical application in orthopedics and ophthalmology for many years has sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14C08J3/03C08L5/08C08L33/12
Inventor 凌沛学陈建英贺艳丽赵成如王勤刘杰汪敏荣晓花
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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