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Anti-human papilloma virus (anti-HPV) external effervescent tablet and preparation method and application thereof

A technology of anti-human papilloma and effervescent tablets, which is applied in the field of anti-human papillomavirus preparations, can solve the problems of limited treatment methods, and achieve the effects of good water solubility, fast onset of action, and prevention and treatment of HPV infection

Inactive Publication Date: 2009-09-02
李东 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, with the deepening of clinical research, the treatment of genital venereal warts infected by human papillomavirus is mostly based on physical methods, such as electrocautery, laser, freezing or acid corrosive agents, and the treatment methods are very limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Preparation method of anti-human papillomavirus effervescent tablet for external use

[0122] Raw material formula: 6.5g of arsenic trioxide, 9g of Brucea javanica oil, 12g of Galla gall powder, 135g of berberine hydrochloride, 56g of rhubarb extract, 4g of borneol.

[0123] Preparation method:

[0124] (1) Pass the raw and auxiliary materials through a 100-mesh sieve respectively, and set aside.

[0125] (2) Brucea javanica oil is mixed with calcium hydrogen phosphate 20g to obtain mixed powder 1, after the arsenic trioxide, mixed powder 1 and microcrystalline cellulose 90g, sodium carboxymethyl starch 50g are mixed uniformly according to the multiplication method, obtained mixed powder II. Then mix the mixed powder II, gallnut powder, rhubarb extract, and berberine hydrochloride evenly, divide into two equal parts, and set aside.

[0126] (3) Take one part of the mixed powder, mix it with 100g of citric acid, add 5% starch slurry to make granules; and mix another p...

Embodiment 2

[0130] Preparation method of anti-human papillomavirus effervescent tablet for external use

[0131] Raw material formula: 4g of arsenic trioxide, 10g of Brucea javanica oil, 10g of Galla gall powder, 120g of berberine hydrochloride, 50g of rhubarb extract, 5g of borneol.

[0132] Preparation method:

[0133] (1) Pass the raw and auxiliary materials through a 100-mesh sieve respectively, and set aside.

[0134] (2) Mix javanica javanica oil with 10 g of calcium hydrogen phosphate to obtain mixed powder I; according to the method of doubling the amount, arsenic trioxide, mixed powder I, microcrystalline cellulose 100 g, and lactose 50 g are uniformly mixed to obtain mixed powder II. Then mix the mixed powder II, gallnut powder, rhubarb extract, and berberine hydrochloride evenly, divide into two equal parts, and set aside.

[0135] (3) Take one part of the mixed powder, mix it evenly with 90g of citric acid, add 0.2% hydroxypropyl methylcellulose 75% ethanol solution to make ...

Embodiment 3

[0138] Example 3 Preparation of anti-human papillomavirus effervescent tablet for external use

[0139] Raw material formula: 4g of arsenic trioxide, 8g of Brucea javanica oil, 8g of Galla gall powder, 100g of berberine hydrochloride, 45g of rhubarb extract, 4g of borneol.

[0140] Preparation method:

[0141] (1) Pass the raw and auxiliary materials through a 100-mesh sieve respectively, and set aside.

[0142] (2) Mix Brucea javanica oil 8g with calcium hydrogen phosphate 20g to obtain mixed powder 1, after the double arsenic trioxide 4g, mixed powder 1 and microcrystalline cellulose 100g, sodium methyl starch 50g are mixed evenly according to the method of doubling, obtain mixed powder Powder II. Mix the mixed powder II, gallnut powder 8g, rhubarb extract 45g, and berberine hydrochloride 100g evenly, divide into two equal parts, and set aside.

[0143] (3) Take one part of the mixed powder, mix it with 100g of citric acid, add 5% starch slurry to make granules, and mix a...

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PUM

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Abstract

The invention relates to an anti-human papilloma virus (anti-HPV) external effervescent tablet and a preparation method and application thereof. The anti-HPV external effervescent tablet comprises the following ingredients by the weight parts: 100 to 300 parts of anti-HPV medicinal powder, 150 to 300 parts of effervescing agent, 80 to 180 parts of diluting agent, 30 to 60 parts of disintegrant, 5 to 20 parts of lubricant and 70 to 90 parts of adhesive. The prepared anti-HPV external effervescent tablet has the advantages of favorable stability, convenient use, rapid disintegration, portability, and the like, has favorable treatment and prevention effects on genital benign or malignant diseases caused by affected HPV, can be used for preventing focal parts from recurring after a vulva, vagina or cervical carcinoma operation, has good water solubility, large foam number, uniform dispersedness and rapid curative effect, is suitable for washout or inunction according to a concentration standard and has the prevention effect on the early HPV infection of male and female genital tracts.

Description

technical field [0001] The invention relates to an anti-human papillomavirus preparation, in particular an anti-human papillomavirus (HPV) effervescent for external use made from arsenic trioxide, Brucea javanica oil, Galla gall powder, berberine hydrochloride, rhubarb extract and borneol Tablets and their preparation methods and applications. Background technique [0002] Human papillomavirus (HPV) is now a common virus that can cause skin and genital infections. There are many types of human papillomavirus. In recent years, the research of molecular biology technology has developed rapidly, and it has been confirmed that there are more than 60 antigen types of human papillomavirus, that is, there are more than 60 similar but different viruses (subtypes) in this family. , 16, and 18 types are the most popular viral factors currently studied abroad for cervical cancer, vulvar cancer, and even penile cancer, and their long-term infection is related to the occurrence of femal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/46A61K47/40A61K47/38A61K47/36A61P31/20A61K35/64A61K33/36A61K31/045A61K31/4375
Inventor 李东温雪松朱桂纯
Owner 李东